Protein detail
ITB3
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
Protein symbol ITB3 | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
Protein Class
Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
719..741; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD61GP3AGPIIIa
Gene Description
Integrin subunit beta 3
Chromosome
17
Position
47253827-47313743
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cells
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- CD markers
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- Human disease related genes:Cardiovascular diseases:Cardiac diseases
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005925 focal adhesion
- GO:0008305 integrin complex
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0016324 apical plasma membrane
- GO:0031092 platelet alpha granule membrane
- GO:0031258 lamellipodium membrane
- GO:0031527 filopodium membrane
- GO:0031528 microvillus membrane
- GO:0032587 ruffle membrane
- GO:0032991 protein-containing complex
- GO:0034683 integrin alphav-beta3 complex
- GO:0035866 alphav-beta3 integrin-PKCalpha complex
- GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
- GO:0035868 alphav-beta3 integrin-HMGB1 complex
- GO:0042470 melanosome
- GO:0043235 receptor complex
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
- GO:0070062 extracellular exosome
- GO:0070442 integrin alphaIIb-beta3 complex
- GO:0071062 alphav-beta3 integrin-vitronectin complex
- GO:0071133 alpha9-beta1 integrin-ADAM8 complex
- GO:0098690 glycinergic synapse
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0001618 virus receptor activity
- GO:0001968 fibronectin binding
- GO:0002020 protease binding
- GO:0003756 protein disulfide isomerase activity
- GO:0005080 protein kinase C binding
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0015026 coreceptor activity
- GO:0017134 fibroblast growth factor binding
- GO:0019899 enzyme binding
- GO:0019960 C-X3-C chemokine binding
- GO:0031994 insulin-like growth factor I binding
- GO:0038132 neuregulin binding
- GO:0042802 identical protein binding
- GO:0043184 vascular endothelial growth factor receptor 2 binding
- GO:0046872 metal ion binding
- GO:0050839 cell adhesion molecule binding
- GO:0050840 extracellular matrix binding
- GO:0070051 fibrinogen binding
Biological Process
KEGG
- hsa03266 Virion - Herpesvirus
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04145 Phagosome
- KEGG:hsa04148 Efferocytosis
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05168 Herpes simplex virus 1 infection
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05206 MicroRNAs in cancer
- KEGG:hsa05410 Hypertrophic cardiomyopathy
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05414 Dilated cardiomyopathy
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-3000178 ecm proteoglycans
- R-hsa-1566948 elastic fibre formation
- R-hsa-1474244 extracellular matrix organization
- R-hsa-354194 grb2 sos provides linkage to mapk signaling for integrins
- R-hsa-109582 hemostasis
- R-hsa-216083 integrin cell surface interactions
- R-hsa-354192 integrin signaling
- R-hsa-373760 l1cam interactions
- R-hsa-5674135 map2k and mapk activation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-9856532 mechanical load activates signaling by piezo1 and integrins in osteocytes
- R-hsa-2129379 molecules associated with elastic fibres
- R-hsa-9675108 nervous system development
- R-hsa-3000171 non integrin membrane ecm interactions
- R-hsa-6802957 oncogenic mapk signaling
- R-hsa-372708 p130cas linkage to mapk signaling for integrins
- R-hsa-210990 pecam1 interactions
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76009 platelet aggregation plug formation
- R-hsa-76005 response to elevated platelet cytosolic ca2
- R-hsa-6802952 signaling by braf and raf1 fusions
- R-hsa-6802946 signaling by moderate kinase activity braf mutants
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-194138 signaling by vegf
- R-hsa-445144 signal transduction by l1
- R-hsa-3000170 syndecan interactions
- R-hsa-2173789 tgf beta receptor signaling activates smads
- R-hsa-9860927 turbulent oscillatory disturbed flow shear stress activates signaling by piezo1 and integrins in endothelial cells
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
16 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ITGB3 | PDPK1 | O15530 | T | 777 | phosphorylation | phosphoELMKEA | KEA:10896934phosphoELM:10896934 |
| ITGB3 | PDPK1 | O15530 | T | 779 | phosphorylation | SIGNORProtMapperHPRDReactome_ProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:18578522SIGNOR:10896934HPRD:10896934phosphoELM:10896934dbPTM:10896934KEA:10896934ProtMapper:10896934 |
| ITGB3 | SRC | P12931 | Y | 785 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:8631894HPRD:18088087KEA:18088087ProtMapper:11723131phosphoELM:8631894KEA:11723131HPRD:11723131 |
| ITGB3 | SRC | P12931 | Y | 773 | phosphorylation | BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMLi2012SIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15699036ProtMapper:15212693SIGNOR:11723131KEA:8631894HPRD:18088087KEA:18088087ProtMapper:11723131phosphoELM:18398066phosphoELM:15699036KEA:11723131HPRD:11723131 |
| ITGB3 | SYK | P43405 | Y | 785 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAphosphoELM | KEA:8631894KEA:11723131KEA:18088087phosphoELM:8631894 |
| ITGB3 | SYK | P43405 | Y | 773 | phosphorylation | Li2012KEA | KEA:8631894KEA:11723131KEA:15699036KEA:18088087 |
| ITGB3 | AKT1 | P31749 | T | 779 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDReactome_ProtMapperdbPTMKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:18578522SIGNOR:10896934HPRD:10896934dbPTM:10896934KEA:10896934ProtMapper:10896934 |
| ITGB3 | PDK1 | Q15118 | T | 779 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | HPRD:18578522SIGNOR:10896934HPRD:10896934KEA:10896934ProtMapper:10896934 |
| ITGB3 | PDK1 | Q15118 | T | 777 | phosphorylation | MIMPKEAphosphoELM_MIMPPhosphoSite_MIMP | KEA:10896934 |
| ITGB3 | CAPN1 | P07384 | A | 761 | cleavage | HPRD | HPRD:7592818 |
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Ligand-Receptor Signaling
70 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| growth_factor_binder | ligand_regulator | GO_Intercell | Yes | No | No | Yes | No |
| ligand_regulator | ligand_regulator | OmniPath | Yes | No | No | Yes | No |
| adhesion | adhesion | Adhesome | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
Regulatory Interaction Network
10 records.
Protein Complex Composition
15 records.
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Sequence, Structure & Domains
Sequences
Length
788
Mass
87,058
Sequence
MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=Beta-3A; IsoId=P05106-1; Sequence=Displayed; Name=Beta-3B; IsoId=P05106-2; Sequence=VSP_002745; Name=Beta-3C; IsoId=P05106-3; Sequence=VSP_002746
Alternative Sequence
768..788; ANNPLYKEATSTFTNITYRGT -> VRDGAGRFLKSLV (in isoform Beta-3B); 768..788; ANNPLYKEATSTFTNITYRGT -> HYAQSLRKWNQPVSIDG (in isoform Beta-3C)
3D Structural Models
Turn
157..159; 169..171; 188..190; 202..207; 308..312; 361..363; 401..403; 472..474; 475..478; 494..498; 616..618; 686..688; 743..759; 761..765; 782..786
Helix
30..33; 35..37; 39..45; 67..72; 77..79; 103..105; 148..150; 151..156; 160..168; 196..200; 226..235; 248..257; 259..262; 285..289; 318..327; 338..340; 341..350; 366..377; 462..466; 509..511; 520..523; 562..564; 591..593; 601..603; 633..645; 650..653; 657..660; 720..737; 771..774; 776..779
Beta Strand
49..52; 55..57; 59..61; 63..66; 86..91; 97..101; 109..111; 112..118; 123..131; 138..145; 175..182; 215..224; 242..246; 268..278; 305..307; 330..336; 355..358; 381..387; 392..400; 404..407; 410..414; 420..429; 434..444; 451..457; 468..470; 479..482; 485..488; 489..491; 500..504; 505..508; 512..518; 524..528; 531..534; 538..540; 542..544; 549..552; 556..561; 565..569; 572..575; 579..581; 598..600; 604..608; 611..614; 620..624; 628..630; 663..670; 676..684; 690..697; 698..700; 703..710; 715..717; 767..770
3D Structure
Electron microscopy (25); NMR spectroscopy (17); X-ray crystallography (72)
Domain & Motif Annotations
Motif
777..783; LIR
Domain (CC)
The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.
Domain (FT)
30..76; PSI; 135..377; VWFA; 463..498; I-EGF 1; 499..548; I-EGF 2; 549..585; I-EGF 3; 586..625; I-EGF 4
Region
203..210; Involved in CX3CL1-, NRG1-, FGF1- and IGF1-binding; 293..313; CX3CL1-binding
Protein Families
Integrin beta chain family
Sequence Similarities
Belongs to the integrin beta chain family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targets
Drug Targets
FDA approved drug targetsClinical trial targetSuccessful targetLiterature-reported target
Drugs
Antibody
Interaction Protein
ENSG00000005961ENSG00000137076ENSG00000138448
Interaction Count
3
Interaction Dataset
intact_biogrid