Protein detail
CD1A
T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)
Entry name CD1A | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 1 | Protein classification CD markersPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)
Protein Class (2)
CD markersPredicted membrane proteins
Protein Function
CD markers
Transmembrane
301..321; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD1
Gene Description
CD1a molecule
Chromosome
1
Position
158254424-158258269
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecificesophagusCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway7
Protein Function
CD markers
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
Reactome (2)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence42
Ligand-Receptor Signaling (40)
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 32230970 |
Sequence, Structure & Domains8
Sequences
Length
327
Mass
37,077
Sequence
MLFLLLPLLAVLPGDGNADGLKEPLSFHVTWIASFYNHSWKQNLVSGWLSDLQTHTWDSNSSTIVFLCPWSRGNFSNEEWKELETLFRIRTIRSFEGIRRYAHELQFEYPFEIQVTGGCELHSGKVSGSFLQLAYQGSDFVSFQNNSWLPYPVAGNMAKHFCKVLNQNQHENDITHNLLSDTCPRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGHLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQRGDILPSADGTWYLRATLEVAAGEAADLSCRVKHSSLEGQDIVLYWEHHSSVGFIILAVIVPLLLLIGLALWFRKRCFC
3D Structural Models
Turn
59..62; 102..106; 192..194
Helix
69..72; 77..101; 152..154; 155..165; 169..180; 182..191; 195..198; 270..272; 283..285
Beta Strand
27..37; 40..49; 52..58; 63..68; 109..119; 129..135; 138..144; 147..150; 205..210; 218..231; 234..239; 248..254; 256..258; 260..269; 276..281; 290..294
3D Structure
X-ray crystallography (15)
Domain & Motif Annotations
Domain (FT)
184..291; Ig-like
Clinical Relevance4
Related Diseases (2)
Biomarker
Approved; Phase 1
Drugs (2)