Protein detail

CD2

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Entry name CD2	UniProt ID P06729	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Protein Class

CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Transmembrane

210..235; Helical

Transmembrane Count

Ensembl

ENSG00000116824

Entrez Gene Symbol

CD2

Gene Synonym

SRBC

Gene Description

CD2 molecule

Chromosome

Position

116754430-116769229

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificskin 1Cell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificT-reg

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

50 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
slam	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

130 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CD2BP2 DDX23 PRPF6 SNRNP40 SNRPB TXNL4A USP39	O94906 O95400 P14678 P83876 Q53GS9 Q96DI7 Q9BUQ8	0:0:0:0:0:0:0	hu.MAP
CD2 CD2BP2	O95400 P06729	1:1	PDB	PDB:1l2z
CD2BP2 TXNL4A	O95400 P83876	3:3	PDB	PDB:1syx
ACTL6A BRCA1 H3-3A H4C4 JUNB PBRM1 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SUMO2	O96019 P17275 P38398 P51531 P51532 P61956 P62805 P84243 Q12824 Q86U86 Q8TAQ2 Q92922 Q92925 Q96GM5	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4868
ACTL6A SMARCC1 SMARCD1 SMARCD2 SMARCE1	O96019 Q92922 Q92925 Q969G3 Q96GM5	0:0:0:0:0	hu.MAP2
FANCD2 FANCI UBB	P0CG47 Q9BXW9 Q9NVI1	0:0:0	KEGG-MEDICUS
FANCD2 FANCI UBC	P0CG48 Q9BXW9 Q9NVI1	2:1:1	PDB	PDB:6vaePDB:6vaf
CDC42 NUDCD2 STMN1	P16949 P60953 Q8WVJ2	0:0:0	hu.MAP
NUDCD2 STMN1	P16949 Q8WVJ2	0:0	hu.MAP
CD22 Q8TCD0 S6B291	P20273 Q8TCD0 S6B291	4:4:4	PDB	PDB:5vl3

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	23161513

Sequence, Structure & Domains

Sequences

Length

351

Mass

39,448

Sequence

MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN

3D Structural Models

Turn

88..90; 139..142

Helix

62..64; 73..75; 99..101

Beta Strand

31..36; 41..43; 52..61; 67..71; 77..80; 84..86; 92..94; 103..111; 116..127; 134..138; 143..147; 155..162; 164..170; 172..175; 180..189; 194..203

3D Structure

NMR spectroscopy (3); X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

243..262; Basic and acidic residues; 269..280; Polar residues; 326..338; Pro residues

Domain (FT)

25..128; Ig-like V-type; 129..209; Ig-like C2-type

Region

61..75; CD58 binding region 1; 106..120; CD58 binding region 2; 237..351; Disordered

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases

Lymphoma Psoriasis

Biomarker

Phase 2; Discontinued in Phase 2

Drug Targets

FDA approved drug targets

Drugs

ZINC CHLORIDE SIPLIZUMAB [3H]HEMICHOLINIUM-3 OCTREOTIDE ACETATE RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN ALDESLEUKIN ALEFACEPT COBALT HEMICHOLINIUM-3

Antibody

CAB002430 HPA003883

Interaction Protein

ENSG00000140368ENSG00000147010ENSG00000169217ENSG00000198087

Interaction Count

Interaction Dataset

intact_biogrid