Protein detail

CD2

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Entry name CD2	UniProt ID P06729	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)

Protein Class

CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Transmembrane

210..235; Helical

Transmembrane Count

Ensembl

ENSG00000116824

Entrez Gene Symbol

CD2

Gene Synonym

SRBC

Gene Description

CD2 molecule

Chromosome

Position

116754430-116769229

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificskin 1Cell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificT-reg

Function & Pathway

Protein Function

CD markers
Predicted intracellular proteins
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

50 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	GO_Intercell	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No
slam	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

130 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CD247	P20963	2	PDB	PDB:2hac
CD247 SHC1	P20963 P29353	1:1	PDB	PDB:1tce
CD247 ZAP70	P20963 P43403	1:1	PDB	PDB:4xz1PDB:2oq1
ATM ATR BLM FANCD2 MLH1 MRE11 MSH2 RAD50 RFC1 TXN2	P35251 P40692 P43246 P49959 P54132 Q13315 Q13535 Q92878 Q99757 Q9BXW9	1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9169
ATM BLM FANCD2 MLH1 MRE11 MSH2 RAD50 RFC1	P35251 P40692 P43246 P49959 P54132 Q13315 Q92878 Q9BXW9	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9512
NUDCD2 PEX19 PPIAL4A PXN SMS	P40855 P49023 P52788 Q8WVJ2 Q9Y536	0:0:0:0:0	Havugimana2012	Havugimana2012:C_476
CD209 FAM217B NEU2 PEX5 TFAP4	P50542 Q01664 Q9NNX6 Q9NTX9 Q9Y3R4	0:0:0:0:0	hu.MAP2
CIP2A DDX20 FANCD2 GEMIN4 SAAL1 XPO4	P57678 Q8TCG1 Q96ER3 Q9BXW9 Q9C0E2 Q9UHI6	0:0:0:0:0:0	hu.MAP
FANCD2 FANCI UBA52	P62987 Q9BXW9 Q9NVI1	1:1:1	PDB	PDB:7zf1
AUP1 CHP1 GPAT3 GPAT4 HACD2 SLC6A15 TEX2	Q53EU6 Q6Y1H2 Q86UL3 Q8IWB9 Q99653 Q9H2J7 Q9Y679	0:0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	23161513

Sequence, Structure & Domains

Sequences

Length

351

Mass

39,448

Sequence

MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN

3D Structural Models

Turn

88..90; 139..142

Helix

62..64; 73..75; 99..101

Beta Strand

31..36; 41..43; 52..61; 67..71; 77..80; 84..86; 92..94; 103..111; 116..127; 134..138; 143..147; 155..162; 164..170; 172..175; 180..189; 194..203

3D Structure

NMR spectroscopy (3); X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

243..262; Basic and acidic residues; 269..280; Polar residues; 326..338; Pro residues

Domain (FT)

25..128; Ig-like V-type; 129..209; Ig-like C2-type

Region

61..75; CD58 binding region 1; 106..120; CD58 binding region 2; 237..351; Disordered

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases

Lymphoma Psoriasis

Biomarker

Phase 2; Discontinued in Phase 2

Drug Targets

FDA approved drug targets

Drugs

ZINC CHLORIDE SIPLIZUMAB [3H]HEMICHOLINIUM-3 OCTREOTIDE ACETATE RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN ALDESLEUKIN ALEFACEPT COBALT HEMICHOLINIUM-3

Antibody

CAB002430 HPA003883

Interaction Protein

ENSG00000140368ENSG00000147010ENSG00000169217ENSG00000198087

Interaction Count

Interaction Dataset

intact_biogrid