Protein detail
CD2
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Entry name CD2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Protein Class
CD markersFDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
210..235; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
SRBC
Gene Description
CD2 molecule
Chromosome
1
Position
116754430-116769229
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell SpecificT-reg
Function & Pathway
Protein Function
- CD markers
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
50 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| slam | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
130 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| C2CD2NCR3LG1SEC14L1 | Q68D85Q92503Q9Y426 | 0:0:0 | hu.MAP2 | |||
| CD244PDXDC1POMT1POMT2 | Q6P996Q9BZW8Q9UKY4Q9Y6A1 | 0:0:0:0 | hu.MAPhu.MAP2 | |||
| CD207S100A7ASUSD3 | Q86SG5Q96L08Q9UJ71 | 0:0:0 | hu.MAP | |||
| FANCD2TNPO1 | Q92973Q9BXW9 | 0:0 | hu.MAP2 | |||
| CARD19CD244 | Q96LW7Q9BZW8 | 0:0 | hu.MAP | |||
| CD244POMT2 | Q9BZW8Q9UKY4 | 0:0 | hu.MAP2 | |||
| CD244POMT1POMT2 | Q9BZW8Q9UKY4Q9Y6A1 | 0:0:0 | hu.MAP | |||
| CD244POMT1 | Q9BZW8Q9Y6A1 | 0:0 | hu.MAP | |||
| CD209 | Q9NNX6 | 10 | PDB | PDB:6ghvPDB:9emrPDB:1k9i | ||
| CD207 | Q9UJ71 | 4 | PDB | PDB:3p5gPDB:4n38PDB:3p5ePDB:3p7gPDB:3c22PDB:3kqgPDB:3p5hPDB:4ak8PDB:5g6uPDB:7ytqPDB:4n36PDB:4n37PDB:4n33PDB:3p5iPDB:3p5dPDB:7wz8PDB:4n34PDB:4n32PDB:3p5fPDB:3p7fPDB:4n35PDB:3p7h |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 23161513 |
Sequence, Structure & Domains
Sequences
Length
351
Mass
39,448
Sequence
MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
3D Structural Models
Turn
88..90; 139..142
Helix
62..64; 73..75; 99..101
Beta Strand
31..36; 41..43; 52..61; 67..71; 77..80; 84..86; 92..94; 103..111; 116..127; 134..138; 143..147; 155..162; 164..170; 172..175; 180..189; 194..203
3D Structure
NMR spectroscopy (3); X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
243..262; Basic and acidic residues; 269..280; Polar residues; 326..338; Pro residues
Domain (FT)
25..128; Ig-like V-type; 129..209; Ig-like C2-type
Region
61..75; CD58 binding region 1; 106..120; CD58 binding region 2; 237..351; Disordered
Clinical Relevance
Disease Involvement
FDA approved drug targets
Biomarker
Phase 2; Discontinued in Phase 2
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000140368ENSG00000147010ENSG00000169217ENSG00000198087
Interaction Count
4
Interaction Dataset
intact_biogrid