Protein detail
PYGL
Glycogen phosphorylase, liver form (EC 2.4.1.1)
Protein symbol PYGL | UniProt ID | EVMP score 0.75 |
Frequency 34 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Basic Information
Protein Names
Glycogen phosphorylase, liver form (EC 2.4.1.1)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
GSD6
Gene Description
Glycogen phosphorylase L
Chromosome
14
Position
50857891-50944483
Frequency
34
EVMP Score
0.75
Fluorescence & Localization
Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
- GO:0002060 purine nucleobase binding
- GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0005536 D-glucose binding
- GO:0008184 glycogen phosphorylase activity
- GO:0016208 AMP binding
- GO:0019842 vitamin binding
- GO:0030170 pyridoxal phosphate binding
- GO:0032052 bile acid binding
- GO:0042802 identical protein binding
KEGG
Reactome
Mediation Categories
Immune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PYGL | PHKG2 | P15735 | S | 15 | phosphorylation | SIGNOR | SIGNOR:22225877 |
| PYGL | PHKG1 | Q16816 | S | 15 | phosphorylation | SIGNOR | SIGNOR:22225877 |
| PYGL | OGT | O15294 | S | 430 | glycosylation | SIGNOR | SIGNOR:34939084 |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PHKG1 | Q16816 | PYGL | P06737 | Yes | Yes | No | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperWang | ProtMapper:22225877SIGNOR:22225877 |
| OGT1 | O15294 | PYGL | P06737 | Yes | Yes | No | SIGNOR | SIGNOR:34939084 |
| RIPK3 | Q9Y572 | PYGL | P06737 | Yes | Yes | No | InnateDBSIGNOR | SIGNOR:19632174InnateDB:21903422 |
| PHKG2 | P15735 | PYGL | P06737 | Yes | Yes | No | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperWang | ProtMapper:22225877SIGNOR:22225877 |
Protein Complex Composition
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster402 | MMS19PYGBPYGLPYGM | P06737P11216P11217Q96T76 | 1:1:1:1 | Compleat | Compleat:HC2245 | 22036573 |
| HPRT1MOB1APYGL | P00492P06737Q9H8S9 | 0:0:0 | hu.MAP | |||
| PYGL | P06737 | 2 | PDB | PDB:1l7xPDB:2zb2PDB:1l5rPDB:3cehPDB:8emsPDB:1exvPDB:3ddwPDB:1l5qPDB:1xoiPDB:1fc0PDB:2atiPDB:3cejPDB:1l5sPDB:3dd1PDB:3ddsPDB:3cemPDB:1em6 | ||
| CHORDC1COTL1DUTPITPNBPSAT1PYGLUBE2M | P06737P33316P48739P61081Q14019Q9UHD1Q9Y617 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| AGLPYGL | P06737P35573 | 0:0 | KEGG-MEDICUS | |||
| MOB1AMOB1BPYGL | P06737Q7L9L4Q9H8S9 | 0:0:0 | hu.MAP | |||
| MOB1APYGL | P06737Q9H8S9 | 0:0 | hu.MAP |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass SpectrometryWestern Blotting | 1 | 37926697 |
Sequence, Structure & Domains
Sequences
Length
847
Mass
97,149
Sequence
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06737-1; Sequence=Displayed; Name=2; IsoId=P06737-2; Sequence=VSP_045339
Alternative Sequence
82..115; Missing (in isoform 2)
3D Structural Models
Turn
8..10; 183..186; 342..345; 467..469; 573..576; 635..637; 670..672; 749..751; 756..759
Helix
11..13; 19..38; 44..46; 49..62; 65..78; 96..102; 106..115; 120..125; 136..150; 195..197; 255..260; 263..268; 270..274; 275..277; 291..314; 327..329; 330..333; 346..356; 362..372; 382..384; 390..396; 398..418; 423..429; 442..448; 458..466; 470..475; 477..479; 490..495; 498..508; 511..513; 516..525; 529..553; 577..593; 615..633; 638..640; 651..657; 658..660; 678..684; 697..704; 706..708; 716..725; 729..735; 737..748; 760..768; 774..792; 795..806; 810..812; 814..824
Beta Strand
14..17; 82..86; 90..93; 130..135; 155..160; 168..172; 175..179; 199..204; 206..210; 213..218; 220..232; 234..237; 239..248; 315..317; 322..325; 334..341; 373..376; 387..389; 419..421; 431..433; 435..437; 439..441; 451..457; 480..482; 554..556; 562..569; 595..597; 602..607; 641..646; 662..666; 688..691; 709..711
3D Structure
Electron microscopy (1); X-ray crystallography (18)
Domain & Motif Annotations
Protein Families
Glycogen phosphorylase family
Sequence Similarities
Belongs to the glycogen phosphorylase family.
Clinical Relevance
Disease Involvement
Disease variantGlycogen storage disease
Interaction Protein
ENSG00000096060ENSG00000100994
Interaction Count
2
Interaction Dataset
biogrid_opencellintact_biogrid_bioplex