Protein detail

PYGL

Glycogen phosphorylase, liver form (EC 2.4.1.1)

Entry name
PYGL
UniProt ID
P06737
EVMP confidence score
0.75
Supporting publications (n)
34
Transmembrane count
Protein classification
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Basic Information
Protein Names
Glycogen phosphorylase, liver form (EC 2.4.1.1)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (6)
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Disease related genes
Ensembl
ENSG00000100504
Entrez Gene Symbol
PYGL
Gene Synonym
GSD6
Gene Description
Glycogen phosphorylase L
Chromosome
14
Position
50857891-50944483
Supporting publications (n)
34
EVMP confidence score
0.75
Fluorescence & Localization
PYGL fluorescence
Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (6)
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Disease related genes
Cellular Component (6)
Molecular Function (11)
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KEGG (6)
Reactome (5)
Mediation Categories (2)
Immune mediationMetabolism mediation
Relations & Evidence22

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PYGLPHKG2P15735S15phosphorylationSIGNORSIGNOR:22225877
PYGLPHKG1Q16816S15phosphorylationSIGNORSIGNOR:22225877
PYGLOGTO15294S430glycosylationSIGNORSIGNOR:34939084

Ligand-Receptor Signaling (7)

7 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYes
ecmecmOmniPathYes
extracellularextracellularOmniPath
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Regulatory Interaction Network (4)

4 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PHKG1Q16816PYGLP06737YesYesiPTMnetSIGNORProtMapperSIGNOR_ProtMapperWangProtMapper:22225877SIGNOR:22225877
OGT1O15294PYGLP06737YesYesSIGNORSIGNOR:34939084
RIPK3Q9Y572PYGLP06737YesYesInnateDBSIGNORSIGNOR:19632174InnateDB:21903422
PHKG2P15735PYGLP06737YesYesiPTMnetSIGNORProtMapperSIGNOR_ProtMapperWangProtMapper:22225877SIGNOR:22225877

Protein Complex Composition (7)

7 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
HT_DM_Cluster402MMS19PYGBPYGLPYGMP06737P11216P11217Q96T761:1:1:1CompleatCompleat:HC224522036573
HPRT1MOB1APYGLP00492P06737Q9H8S90:0:0hu.MAP
PYGLP067372PDBPDB:1l7xPDB:2zb2PDB:1l5rPDB:3cehPDB:8emsPDB:1exvPDB:3ddwPDB:1l5qPDB:1xoiPDB:1fc0PDB:2atiPDB:3cejPDB:1l5sPDB:3dd1PDB:3ddsPDB:3cemPDB:1em6
CHORDC1COTL1DUTPITPNBPSAT1PYGLUBE2MP06737P33316P48739P61081Q14019Q9UHD1Q9Y6170:0:0:0:0:0:0hu.MAP2
AGLPYGLP06737P355730:0KEGG-MEDICUS
MOB1AMOB1BPYGLP06737Q7L9L4Q9H8S90:0:0hu.MAP
MOB1APYGLP06737Q9H8S90:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass SpectrometryWestern Blotting137926697
Sequence, Structure & Domains

Sequences

Length
847
Mass
97,149
Sequence
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06737-1; Sequence=Displayed; Name=2; IsoId=P06737-2; Sequence=VSP_045339
Alternative Sequence
82..115; Missing (in isoform 2)

3D Structural Models

Turn
8..10; 183..186; 342..345; 467..469; 573..576; 635..637; 670..672; 749..751; 756..759
Helix
11..13; 19..38; 44..46; 49..62; 65..78; 96..102; 106..115; 120..125; 136..150; 195..197; 255..260; 263..268; 270..274; 275..277; 291..314; 327..329; 330..333; 346..356; 362..372; 382..384; 390..396; 398..418; 423..429; 442..448; 458..466; 470..475; 477..479; 490..495; 498..508; 511..513; 516..525; 529..553; 577..593; 615..633; 638..640; 651..657; 658..660; 678..684; 697..704; 706..708; 716..725; 729..735; 737..748; 760..768; 774..792; 795..806; 810..812; 814..824
Beta Strand
14..17; 82..86; 90..93; 130..135; 155..160; 168..172; 175..179; 199..204; 206..210; 213..218; 220..232; 234..237; 239..248; 315..317; 322..325; 334..341; 373..376; 387..389; 419..421; 431..433; 435..437; 439..441; 451..457; 480..482; 554..556; 562..569; 595..597; 602..607; 641..646; 662..666; 688..691; 709..711
3D Structure
Electron microscopy (1); X-ray crystallography (18)

Domain & Motif Annotations

Protein Families
Glycogen phosphorylase family
Sequence Similarities
Belongs to the glycogen phosphorylase family.
Clinical Relevance
Disease Involvement (2)
Disease variantGlycogen storage disease
Related Diseases
Glycogen storage disease
Drugs (4)
DEXAMETHASONEMETHOTREXATEASPARAGINASEPSN357
Antibody (2)
HPA000962HPA004119
Interaction Protein (2)
ENSG00000096060ENSG00000100994
Interaction Count
2
Interaction Dataset (2)
biogrid_opencellintact_biogrid_bioplex
Supporting Publications34
PMIDTitleRelated sentences
26826536[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].No related sentences available
27821849Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.No related sentences available
28680152Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity.No related sentences available
30875722Human Heart Explant-Derived Extracellular Vesicles: Characterization and Effects on the In Vitro Recellularization of Decellularized Heart Valves.No related sentences available
30915084Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.No related sentences available
31805958Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.No related sentences available
32230970Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.No related sentences available
32357574Extracellular Vesicles Secreted by Corneal Epithelial Cells Promote Myofibroblast Differentiation.No related sentences available
32854315Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
33304478The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.No related sentences available
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