Protein detail

PYGL

Glycogen phosphorylase, liver form (EC 2.4.1.1)

Entry name PYGL	UniProt ID P06737	EVMP confidence score 0.75
Supporting publications (n) 34	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Glycogen phosphorylase, liver form (EC 2.4.1.1)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (6)

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Ensembl

ENSG00000100504

Entrez Gene Symbol

PYGL

Gene Synonym

GSD6

Gene Description

Glycogen phosphorylase L

Chromosome

Position

50857891-50944483

Supporting publications (n)

EVMP confidence score

0.75

Fluorescence & Localization3

Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway6

Protein Function (6)

Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component (6)

Molecular Function (11)

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KEGG (6)

Reactome (5)

Mediation Categories (2)

Immune mediationMetabolism mediation

Relations & Evidence22

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PYGL	PHKG2	P15735	S	15	phosphorylation	SIGNOR	SIGNOR:22225877
PYGL	PHKG1	Q16816	S	15	phosphorylation	SIGNOR	SIGNOR:22225877
PYGL	OGT	O15294	S	430	glycosylation	SIGNOR	SIGNOR:34939084

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PHKG1	Q16816	PYGL	P06737	Yes	Yes	No	iPTMnetSIGNORProtMapperSIGNOR_ProtMapperWang	ProtMapper:22225877 SIGNOR:22225877
OGT1	O15294	PYGL	P06737	Yes	Yes	No	SIGNOR	SIGNOR:34939084
RIPK3	Q9Y572	PYGL	P06737	Yes	Yes	No	InnateDBSIGNOR	SIGNOR:19632174 InnateDB:21903422
PHKG2	P15735	PYGL	P06737	Yes	Yes	No	iPTMnetSIGNORProtMapperSIGNOR_ProtMapperWang	ProtMapper:22225877 SIGNOR:22225877

Protein Complex Composition (7)

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster402	MMS19 PYGB PYGL PYGM	P06737 P11216 P11217 Q96T76	1:1:1:1	Compleat	Compleat:HC2245	22036573
	HPRT1 MOB1A PYGL	P00492 P06737 Q9H8S9	0:0:0	hu.MAP
	PYGL	P06737	2	PDB	PDB:1l7xPDB:2zb2PDB:1l5rPDB:3cehPDB:8emsPDB:1exvPDB:3ddwPDB:1l5qPDB:1xoiPDB:1fc0PDB:2atiPDB:3cejPDB:1l5sPDB:3dd1PDB:3ddsPDB:3cemPDB:1em6
	CHORDC1 COTL1 DUT PITPNB PSAT1 PYGL UBE2M	P06737 P33316 P48739 P61081 Q14019 Q9UHD1 Q9Y617	0:0:0:0:0:0:0	hu.MAP2
	AGL PYGL	P06737 P35573	0:0	KEGG-MEDICUS
	MOB1A MOB1B PYGL	P06737 Q7L9L4 Q9H8S9	0:0:0	hu.MAP
	MOB1A PYGL	P06737 Q9H8S9	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass SpectrometryWestern Blotting	1	37926697

Sequence, Structure & Domains11

Sequences

Length

847

Mass

97,149

Sequence

MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06737-1; Sequence=Displayed; Name=2; IsoId=P06737-2; Sequence=VSP_045339

Alternative Sequence

82..115; Missing (in isoform 2)

3D Structural Models

Turn

8..10; 183..186; 342..345; 467..469; 573..576; 635..637; 670..672; 749..751; 756..759

Helix

11..13; 19..38; 44..46; 49..62; 65..78; 96..102; 106..115; 120..125; 136..150; 195..197; 255..260; 263..268; 270..274; 275..277; 291..314; 327..329; 330..333; 346..356; 362..372; 382..384; 390..396; 398..418; 423..429; 442..448; 458..466; 470..475; 477..479; 490..495; 498..508; 511..513; 516..525; 529..553; 577..593; 615..633; 638..640; 651..657; 658..660; 678..684; 697..704; 706..708; 716..725; 729..735; 737..748; 760..768; 774..792; 795..806; 810..812; 814..824

Beta Strand

14..17; 82..86; 90..93; 130..135; 155..160; 168..172; 175..179; 199..204; 206..210; 213..218; 220..232; 234..237; 239..248; 315..317; 322..325; 334..341; 373..376; 387..389; 419..421; 431..433; 435..437; 439..441; 451..457; 480..482; 554..556; 562..569; 595..597; 602..607; 641..646; 662..666; 688..691; 709..711

3D Structure

Electron microscopy (1); X-ray crystallography (18)

Domain & Motif Annotations

Protein Families

Glycogen phosphorylase family

Sequence Similarities

Belongs to the glycogen phosphorylase family.

Clinical Relevance6

Disease Involvement (2)

Disease variantGlycogen storage disease

Drugs (4)

DEXAMETHASONE METHOTREXATE ASPARAGINASE PSN357

Antibody (2)

HPA000962 HPA004119

Interaction Protein (2)

ENSG00000096060ENSG00000100994

Interaction Count

Interaction Dataset (2)

biogrid_opencellintact_biogrid_bioplex

Supporting Publications34

PMID	Title	Abstract
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
28680152	Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity.	No abstract available
30875722	Human Heart Explant-Derived Extracellular Vesicles: Characterization and Effects on the In Vitro Recellularization of Decellularized Heart Valves.	No abstract available
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No abstract available
32357574	Extracellular Vesicles Secreted by Corneal Epithelial Cells Promote Myofibroblast Differentiation.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
33304478	The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.	No abstract available

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