Protein detail
PYGL
Glycogen phosphorylase, liver form (EC 2.4.1.1)
Entry name PYGL | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 34 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Glycogen phosphorylase, liver form (EC 2.4.1.1)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (6)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
GSD6
Gene Description
Glycogen phosphorylase L
Chromosome
14
Position
50857891-50944483
Supporting publications (n)
34
EVMP confidence score
0.75
Fluorescence & Localization
Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (6)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component (6)
Molecular Function (11)
- GO:0002060 purine nucleobase binding
- GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0005536 D-glucose binding
- GO:0008184 glycogen phosphorylase activity
- GO:0016208 AMP binding
- GO:0019842 vitamin binding
- GO:0030170 pyridoxal phosphate binding
- GO:0032052 bile acid binding
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KEGG (6)
Reactome (5)
Mediation Categories (2)
Immune mediationMetabolism mediation
Relations & Evidence22
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PYGL | PHKG2 | P15735 | S | 15 | phosphorylation | SIGNOR | SIGNOR:22225877 |
| PYGL | PHKG1 | Q16816 | S | 15 | phosphorylation | SIGNOR | SIGNOR:22225877 |
| PYGL | OGT | O15294 | S | 430 | glycosylation | SIGNOR | SIGNOR:34939084 |
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | ||||
| ecm | ecm | OmniPath | Yes | ||||
| extracellular | extracellular | OmniPath | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PHKG1 | Q16816 | PYGL | P06737 | Yes | Yes | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperWang | ProtMapper:22225877SIGNOR:22225877 | |
| OGT1 | O15294 | PYGL | P06737 | Yes | Yes | SIGNOR | SIGNOR:34939084 | |
| RIPK3 | Q9Y572 | PYGL | P06737 | Yes | Yes | InnateDBSIGNOR | SIGNOR:19632174InnateDB:21903422 | |
| PHKG2 | P15735 | PYGL | P06737 | Yes | Yes | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperWang | ProtMapper:22225877SIGNOR:22225877 |
Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster402 | MMS19PYGBPYGLPYGM | P06737P11216P11217Q96T76 | 1:1:1:1 | Compleat | Compleat:HC2245 | 22036573 |
| HPRT1MOB1APYGL | P00492P06737Q9H8S9 | 0:0:0 | hu.MAP | |||
| PYGL | P06737 | 2 | PDB | PDB:1l7xPDB:2zb2PDB:1l5rPDB:3cehPDB:8emsPDB:1exvPDB:3ddwPDB:1l5qPDB:1xoiPDB:1fc0PDB:2atiPDB:3cejPDB:1l5sPDB:3dd1PDB:3ddsPDB:3cemPDB:1em6 | ||
| CHORDC1COTL1DUTPITPNBPSAT1PYGLUBE2M | P06737P33316P48739P61081Q14019Q9UHD1Q9Y617 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| AGLPYGL | P06737P35573 | 0:0 | KEGG-MEDICUS | |||
| MOB1AMOB1BPYGL | P06737Q7L9L4Q9H8S9 | 0:0:0 | hu.MAP | |||
| MOB1APYGL | P06737Q9H8S9 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass SpectrometryWestern Blotting | 1 | 37926697 |
Sequence, Structure & Domains
Sequences
Length
847
Mass
97,149
Sequence
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06737-1; Sequence=Displayed; Name=2; IsoId=P06737-2; Sequence=VSP_045339
Alternative Sequence
82..115; Missing (in isoform 2)
3D Structural Models
Turn
8..10; 183..186; 342..345; 467..469; 573..576; 635..637; 670..672; 749..751; 756..759
Helix
11..13; 19..38; 44..46; 49..62; 65..78; 96..102; 106..115; 120..125; 136..150; 195..197; 255..260; 263..268; 270..274; 275..277; 291..314; 327..329; 330..333; 346..356; 362..372; 382..384; 390..396; 398..418; 423..429; 442..448; 458..466; 470..475; 477..479; 490..495; 498..508; 511..513; 516..525; 529..553; 577..593; 615..633; 638..640; 651..657; 658..660; 678..684; 697..704; 706..708; 716..725; 729..735; 737..748; 760..768; 774..792; 795..806; 810..812; 814..824
Beta Strand
14..17; 82..86; 90..93; 130..135; 155..160; 168..172; 175..179; 199..204; 206..210; 213..218; 220..232; 234..237; 239..248; 315..317; 322..325; 334..341; 373..376; 387..389; 419..421; 431..433; 435..437; 439..441; 451..457; 480..482; 554..556; 562..569; 595..597; 602..607; 641..646; 662..666; 688..691; 709..711
3D Structure
Electron microscopy (1); X-ray crystallography (18)
Domain & Motif Annotations
Protein Families
Glycogen phosphorylase family
Sequence Similarities
Belongs to the glycogen phosphorylase family.
Clinical Relevance
Disease Involvement (2)
Disease variantGlycogen storage disease
Related Diseases
Interaction Protein (2)
ENSG00000096060ENSG00000100994
Interaction Count
2
Interaction Dataset (2)
biogrid_opencellintact_biogrid_bioplex
Supporting Publications34
| PMID | Title | Related sentences |
|---|---|---|
| 33592500 | A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia. | No related sentences available |
| 34064677 | Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells. | No related sentences available |
| 34576246 | Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators. | No related sentences available |
| 35119778 | Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis. | No related sentences available |
| 35763629 | Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers. | No related sentences available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No related sentences available |
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No related sentences available |
| 36497184 | Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells. | No related sentences available |
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No related sentences available |
| 37204515 | Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma. | No related sentences available |