Protein detail
PYGL
Glycogen phosphorylase, liver form (EC 2.4.1.1)
Entry name PYGL | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 34 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Glycogen phosphorylase, liver form (EC 2.4.1.1)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (6)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
GSD6
Gene Description
Glycogen phosphorylase L
Chromosome
14
Position
50857891-50944483
Supporting publications (n)
34
EVMP confidence score
0.75
Fluorescence & Localization
Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (6)
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component (6)
Molecular Function (11)
- GO:0002060 purine nucleobase binding
- GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0005536 D-glucose binding
- GO:0008184 glycogen phosphorylase activity
- GO:0016208 AMP binding
- GO:0019842 vitamin binding
- GO:0030170 pyridoxal phosphate binding
- GO:0032052 bile acid binding
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KEGG (6)
Reactome (5)
Mediation Categories (2)
Immune mediationMetabolism mediation
Relations & Evidence22
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PYGL | PHKG2 | P15735 | S | 15 | phosphorylation | SIGNOR | SIGNOR:22225877 |
| PYGL | PHKG1 | Q16816 | S | 15 | phosphorylation | SIGNOR | SIGNOR:22225877 |
| PYGL | OGT | O15294 | S | 430 | glycosylation | SIGNOR | SIGNOR:34939084 |
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | ||||
| ecm | ecm | OmniPath | Yes | ||||
| extracellular | extracellular | OmniPath | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PHKG1 | Q16816 | PYGL | P06737 | Yes | Yes | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperWang | ProtMapper:22225877SIGNOR:22225877 | |
| OGT1 | O15294 | PYGL | P06737 | Yes | Yes | SIGNOR | SIGNOR:34939084 | |
| RIPK3 | Q9Y572 | PYGL | P06737 | Yes | Yes | InnateDBSIGNOR | SIGNOR:19632174InnateDB:21903422 | |
| PHKG2 | P15735 | PYGL | P06737 | Yes | Yes | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperWang | ProtMapper:22225877SIGNOR:22225877 |
Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster402 | MMS19PYGBPYGLPYGM | P06737P11216P11217Q96T76 | 1:1:1:1 | Compleat | Compleat:HC2245 | 22036573 |
| HPRT1MOB1APYGL | P00492P06737Q9H8S9 | 0:0:0 | hu.MAP | |||
| PYGL | P06737 | 2 | PDB | PDB:1l7xPDB:2zb2PDB:1l5rPDB:3cehPDB:8emsPDB:1exvPDB:3ddwPDB:1l5qPDB:1xoiPDB:1fc0PDB:2atiPDB:3cejPDB:1l5sPDB:3dd1PDB:3ddsPDB:3cemPDB:1em6 | ||
| CHORDC1COTL1DUTPITPNBPSAT1PYGLUBE2M | P06737P33316P48739P61081Q14019Q9UHD1Q9Y617 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| AGLPYGL | P06737P35573 | 0:0 | KEGG-MEDICUS | |||
| MOB1AMOB1BPYGL | P06737Q7L9L4Q9H8S9 | 0:0:0 | hu.MAP | |||
| MOB1APYGL | P06737Q9H8S9 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass SpectrometryWestern Blotting | 1 | 37926697 |
Sequence, Structure & Domains
Sequences
Length
847
Mass
97,149
Sequence
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06737-1; Sequence=Displayed; Name=2; IsoId=P06737-2; Sequence=VSP_045339
Alternative Sequence
82..115; Missing (in isoform 2)
3D Structural Models
Turn
8..10; 183..186; 342..345; 467..469; 573..576; 635..637; 670..672; 749..751; 756..759
Helix
11..13; 19..38; 44..46; 49..62; 65..78; 96..102; 106..115; 120..125; 136..150; 195..197; 255..260; 263..268; 270..274; 275..277; 291..314; 327..329; 330..333; 346..356; 362..372; 382..384; 390..396; 398..418; 423..429; 442..448; 458..466; 470..475; 477..479; 490..495; 498..508; 511..513; 516..525; 529..553; 577..593; 615..633; 638..640; 651..657; 658..660; 678..684; 697..704; 706..708; 716..725; 729..735; 737..748; 760..768; 774..792; 795..806; 810..812; 814..824
Beta Strand
14..17; 82..86; 90..93; 130..135; 155..160; 168..172; 175..179; 199..204; 206..210; 213..218; 220..232; 234..237; 239..248; 315..317; 322..325; 334..341; 373..376; 387..389; 419..421; 431..433; 435..437; 439..441; 451..457; 480..482; 554..556; 562..569; 595..597; 602..607; 641..646; 662..666; 688..691; 709..711
3D Structure
Electron microscopy (1); X-ray crystallography (18)
Domain & Motif Annotations
Protein Families
Glycogen phosphorylase family
Sequence Similarities
Belongs to the glycogen phosphorylase family.
Clinical Relevance
Disease Involvement (2)
Disease variantGlycogen storage disease
Related Diseases
Interaction Protein (2)
ENSG00000096060ENSG00000100994
Interaction Count
2
Interaction Dataset (2)
biogrid_opencellintact_biogrid_bioplex
Supporting Publications34
| PMID | Title | Related sentences |
|---|---|---|
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No related sentences available |
| 37670049 | Proteomic and functional characterisation of extracellular vesicles from collagen VI deficient human fibroblasts reveals a role in cell motility. | No related sentences available |
| 38014595 | Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No related sentences available |
| 38607062 | Enrichment, Characterization, and Proteomic Profiling of Small Extracellular Vesicles Derived from Human Limbal Mesenchymal Stromal Cells and Melanocytes. | No related sentences available |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |
| 38891077 | Altered Extracellular Vesicle-Derived Protein and microRNA Signatures in Bronchoalveolar Lavage Fluid from Patients with Chronic Obstructive Pulmonary Disease. | No related sentences available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |