Protein detail

CSF1R

Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)

Entry name CSF1R	UniProt ID P07333	EVMP confidence score 0.63
Supporting publications (n) 6	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)

Protein Class (11)

Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters

Protein Function (12)

Predicted intracellular proteins
ENZYME proteins:Transferases
Human disease related genes:Cancers:Cancers of the breast and female genital organs
Human disease related genes:Nervous system diseases:Neurodegenerative diseases
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Transporters:Accessory Factors Involved in Transport
Kinases:Tyr protein kinases

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Transmembrane

518..538; Helical

Transmembrane Count

Ensembl

ENSG00000182578

Entrez Gene Symbol

CSF1R

Gene Synonym (4)

C-FMSCD115CSFRFMS

Gene Description

Colony stimulating factor 1 receptor

Chromosome

Position

150053291-150113372

Supporting publications (n)

EVMP confidence score

0.63

Fluorescence & Localization2

Single-Nuclei Brain Specificcommitted oligodendrocyte precursor

Function & Pathway8

Protein Function (12)

Predicted intracellular proteins
ENZYME proteins:Transferases
Human disease related genes:Cancers:Cancers of the breast and female genital organs
Human disease related genes:Nervous system diseases:Neurodegenerative diseases
CD markers
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Transporters:Accessory Factors Involved in Transport
Kinases:Tyr protein kinases

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Cellular Component (6)

Molecular Function (8)

Biological Process (3)

KEGG (11)

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Reactome (6)

Canonical Pathways (3)

M64 Pid s1p s1p4 pathway
M103 Pid s1p s1p1 pathway
M155 Pid s1p meta pathway

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence75

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CSF1R	PTPN2	P17706	Y	809	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:16705167
CSF1R	PTPN1	P18031	Y	809	phosphorylation	NCI-PID_ProtMapperProtMapper	ProtMapper:16477024
CSF1R	IL34	Q6ZMJ4	Y	708	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:29796177
CSF1R	IGF1R	P08069	Y	699	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (66)

66 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No

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Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL34	Q6ZMJ4	CSF1R	P07333	Yes	Yes	No	iTALKICELLNETSIGNORProtMapperHINTDIPCellChatDBtalklrscConnectIntActRamilowski2015_Baccin2019Ramilowski2015CellPhoneDBReactome_LRdbBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellTalkDBFantom5_LRdbSparser_ProtMapperconnectomeDB2020LRdb	DIP:22483114 IntAct:22483114 connectomeDB2020:22729249 HINT:22483114 ICELLNET:26095744 scConnect:18467591 LRdb:22729249 CellTalkDB:22729249 Baccin2019:30205037 Cellinker:31616414 SIGNOR:24890514 HINT:23478061 SIGNOR:39416792 DIP:23478061 Ramilowski2015:22729249 IntAct:23478061 ProtMapper:29796177 talklr:22729249
CSF1R	P07333	CTND1	O60716	Yes	Yes	No	REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper	ProtMapper:21049007 SIGNOR:21049007
CSF1	P09603	CSF1R	P07333	Yes	Yes	No	iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTUniProt_LRdbDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007IntActDLRP_talklrRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	HINT:22483114 HPMR:7883784 HPMR:1702217 Baccin2019:2408759 connectomeDB2020:7883784 Baccin2019:7883784 IntAct:26235028 IntAct:22153499 IntAct:22483114 ICELLNET:26095744 HPRD:8355686 HPRD:2408759 LRdb:2408759 connectomeDB2020:8355686 SIGNOR:24890514 CellTalkDB:8355686 DIP:22483114 Cellinker:7883784 DIP:22153499 Baccin2019:8355686 IntAct:22902366 HINT:8355686 Cellinker:2408759 SIGNOR:39416792 Cellinker:8355686 HINT:22153499 HINT:26235028 DIP:22902366 DIP:26235028 connectomeDB2020:2408759 LRdb:8355686 LRdb:7883784 HINT:22902366
CSF1R	P07333	PLCG2	P16885	Yes	Yes	No	SIGNOR	SIGNOR:24890514

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryFlow cytometryMORPH	6	37563857 40730843 36146834 31805958 38207106 32854315

Sequence, Structure & Domains15

Sequences

Length

972

Mass

107,984

Sequence

MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07333-1; Sequence=Displayed; Name=2; IsoId=P07333-2; Sequence=VSP_047757, VSP_047758

Alternative Sequence

297..306; ESAYLNLSSE -> GTPSPSLCPA (in isoform 2); 307..972; Missing (in isoform 2)

3D Structural Models

Turn

55..57; 158..160; 270..272; 443..445; 605..608; 684..686; 742..744; 806..808

Helix

76..78; 132..137; 143..145; 169..171; 373..375; 566..568; 573..575; 579..581; 624..640; 671..683; 752..771; 781..783; 788..790; 798..800; 803..805; 819..821; 824..829; 834..849; 863..870; 883..892; 897..899; 903..913

Beta Strand

22..25; 27..32; 38..43; 49..51; 58..62; 64..73; 80..85; 95..101; 108..111; 113..118; 123..125; 127..130; 139..142; 154..157; 161..166; 173..181; 184..187; 191..196; 204..208; 210..215; 216..218; 220..231; 234..239; 248..252; 257..267; 274..282; 285..298; 300..304; 309..314; 319..329; 332..338; 340..342; 351..354; 361..368; 377..385; 388..411; 414..425; 428..437; 446..454; 456..459; 466..473; 479..488; 493..498; 551..553; 556..560; 582..590; 592..604; 609..618; 649..653; 655..658; 660..664; 784..786; 792..794; 809..811; 815..817

3D Structure

X-ray crystallography (26)

Domain & Motif Annotations

Compositional Bias

928..940; Low complexity

Domain (CC)

The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.; DOMAIN: The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.

Domain (FT)

21..104; Ig-like C2-type 1; 107..197; Ig-like C2-type 2; 203..290; Ig-like C2-type 3; 299..399; Ig-like C2-type 4; 402..502; Ig-like C2-type 5; 582..910; Protein kinase

Region

542..574; Regulatory juxtamembrane domain; 796..818; Activation loop; 918..950; Disordered

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
CSF-1/PDGF receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Clinical Relevance9

Disease Involvement (5)

Cancer-related genesDisease variantFDA approved drug targetsNeurodegenerationProto-oncogene

Related Diseases (11)

Alzheimer disease Bone/articular cartilage neoplasm Diabetes mellitus Idiopathic interstitial pneumonitis Inflammatory arthropathy Malignant haematopoietic neoplasm Motor neuron disease Pancreatic cancer Phakomatoses/hamartoneoplastic syndrome Solid tumour/cancer Stomach cancer

Biomarker

Phase 3; Approved; Phase 1/2; Phase 2; Phase 1

Drug Targets

FDA approved drug targets

Antibody (2)

CAB008970 HPA012323

Interaction Protein (2)

ENSG00000133216ENSG00000135333

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications6

PMID	Title	Abstract
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
34599510	Inflammatory capacity of exosomes released in the early stages of acute pancreatitis predicts the severity of the disease.	In particular, an increase in the amount of S100A8 and S100A9 carried by exosomes of severe pancreatitis suggests that the mechanism of action of exosomes is mediated by the effect of these proteins on NADPH oxidase.
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38895962	A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis.	No abstract available
39001700	Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.	No abstract available