Protein detail
CSF1R
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Protein symbol CSF1R | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters |
Basic Information
Protein Names
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Protein Class
Cancer-related genesCD markersDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
518..538; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
C-FMSCD115CSFRFMS
Gene Description
Colony stimulating factor 1 receptor
Chromosome
5
Position
150053291-150113372
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Single-Nuclei Brain Specificcommitted oligodendrocyte precursor
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- CD markers
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04014 Ras signaling pathway
- KEGG:hsa04015 Rap1 signaling pathway
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04061 Viral protein interaction with cytokine and cytokine receptor
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04640 Hematopoietic cell lineage
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05202 Transcriptional misregulation in cancer
- KEGG:hsa05221 Acute myeloid leukemia
Reactome
Canonical Pathways
- M64 Pid s1p s1p4 pathway
- M103 Pid s1p s1p1 pathway
- M155 Pid s1p meta pathway
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CSF1R | PTPN2 | P17706 | Y | 809 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:16705167 |
| CSF1R | PTPN1 | P18031 | Y | 809 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:16477024 |
| CSF1R | IL34 | Q6ZMJ4 | Y | 708 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:29796177 |
| CSF1R | IGF1R | P08069 | Y | 699 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
66 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IL34 | Q6ZMJ4 | CSF1R | P07333 | Yes | Yes | No | iTALKICELLNETSIGNORProtMapperHINTDIPCellChatDBtalklrscConnectIntActRamilowski2015_Baccin2019Ramilowski2015CellPhoneDBReactome_LRdbBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellTalkDBFantom5_LRdbSparser_ProtMapperconnectomeDB2020LRdb | DIP:22483114IntAct:22483114connectomeDB2020:22729249HINT:22483114ICELLNET:26095744scConnect:18467591LRdb:22729249CellTalkDB:22729249Baccin2019:30205037Cellinker:31616414SIGNOR:24890514HINT:23478061SIGNOR:39416792DIP:23478061Ramilowski2015:22729249IntAct:23478061ProtMapper:29796177talklr:22729249 |
| CSF1R | P07333 | CTND1 | O60716 | Yes | Yes | No | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | ProtMapper:21049007SIGNOR:21049007 |
| CSF1 | P09603 | CSF1R | P07333 | Yes | Yes | No | iTALKGuide2Pharma_LRdbICELLNETSIGNORHINTUniProt_LRdbDIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDCui2007IntActDLRP_talklrRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE | HINT:22483114HPMR:7883784HPMR:1702217Baccin2019:2408759connectomeDB2020:7883784Baccin2019:7883784IntAct:26235028IntAct:22153499IntAct:22483114ICELLNET:26095744HPRD:8355686HPRD:2408759LRdb:2408759connectomeDB2020:8355686SIGNOR:24890514CellTalkDB:8355686DIP:22483114Cellinker:7883784DIP:22153499Baccin2019:8355686IntAct:22902366HINT:8355686Cellinker:2408759SIGNOR:39416792Cellinker:8355686HINT:22153499HINT:26235028DIP:22902366DIP:26235028connectomeDB2020:2408759LRdb:8355686LRdb:7883784HINT:22902366 |
| CSF1R | P07333 | PLCG2 | P16885 | Yes | Yes | No | SIGNOR | SIGNOR:24890514 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
972
Mass
107,984
Sequence
MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07333-1; Sequence=Displayed; Name=2; IsoId=P07333-2; Sequence=VSP_047757, VSP_047758
Alternative Sequence
297..306; ESAYLNLSSE -> GTPSPSLCPA (in isoform 2); 307..972; Missing (in isoform 2)
3D Structural Models
Turn
55..57; 158..160; 270..272; 443..445; 605..608; 684..686; 742..744; 806..808
Helix
76..78; 132..137; 143..145; 169..171; 373..375; 566..568; 573..575; 579..581; 624..640; 671..683; 752..771; 781..783; 788..790; 798..800; 803..805; 819..821; 824..829; 834..849; 863..870; 883..892; 897..899; 903..913
Beta Strand
22..25; 27..32; 38..43; 49..51; 58..62; 64..73; 80..85; 95..101; 108..111; 113..118; 123..125; 127..130; 139..142; 154..157; 161..166; 173..181; 184..187; 191..196; 204..208; 210..215; 216..218; 220..231; 234..239; 248..252; 257..267; 274..282; 285..298; 300..304; 309..314; 319..329; 332..338; 340..342; 351..354; 361..368; 377..385; 388..411; 414..425; 428..437; 446..454; 456..459; 466..473; 479..488; 493..498; 551..553; 556..560; 582..590; 592..604; 609..618; 649..653; 655..658; 660..664; 784..786; 792..794; 809..811; 815..817
3D Structure
X-ray crystallography (26)
Domain & Motif Annotations
Compositional Bias
928..940; Low complexity
Domain (CC)
The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.; DOMAIN: The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase.
Domain (FT)
21..104; Ig-like C2-type 1; 107..197; Ig-like C2-type 2; 203..290; Ig-like C2-type 3; 299..399; Ig-like C2-type 4; 402..502; Ig-like C2-type 5; 582..910; Protein kinase
Region
542..574; Regulatory juxtamembrane domain; 796..818; Activation loop; 918..950; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- CSF-1/PDGF receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsNeurodegenerationProto-oncogene
Related Diseases
Biomarker
Phase 3; Approved; Phase 1/2; Phase 2; Phase 1
Drug Targets
FDA approved drug targets
Drugs
CENISERTIBPEXIDARTINIB HYDROCHLORIDENULLLINIFANIBVATALANIBAST-487IMATINIBIMC-CS4GO-6976TANDUTINIBAMG-820DACTOLISIBVIMSELTINIBGW-2580PAZOPANIBPANOBINOSTATEDICOTINIBPD-0166285CEDIRANIBCT-1578ARRY-382ALSTERPAULLONEPEXIDARTINIBCABIRALIZUMABBLZ-945QUIZARTINIBMCS-110ANTI-C-FMS MONOCLONAL ANTIBODY AMG 820DOVITINIBSP-600125NVP-TAE684MASITINIBAXATILIMABPROGESTINCHEMBL:CHEMBL546797SORAFENIBCHEMBL:CHEMBL365617PLX-5622DASATINIB ANHYDROUSENMD-2076RG-1530KENPAULLONEILORASERTIBEMACTUZUMABHESPERADINPD-360324SUNITINIBPLX-7486ENTRECTINIBBAY 61-3606CYC-116SERALUTINIBJNJ-7706621GW843682XSULFATINIBPLX7486
Interaction Protein
ENSG00000133216ENSG00000135333
Interaction Count
2
Interaction Dataset
intact_biogrid