Protein detail

CO8A

Complement component C8 alpha chain (Complement component 8 subunit alpha)

Protein symbol CO8A	UniProt ID P07357	EVMP score 0.50
Frequency 1	Transmembrane count 4	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Complement component C8 alpha chain (Complement component 8 subunit alpha)

Protein Function

Potential drug targets
Human disease related genes:Immune system diseases:Primary immunodeficiency
Transporters:Transporter channels and pores
Predicted secreted proteins
Disease related genes

Transmembrane

248..256; Beta stranded; 259..266; Beta stranded; 377..384; Beta stranded; 390..395; Beta stranded

Transmembrane Count

Ensembl

ENSG00000157131

Entrez Gene Symbol

C8A

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecificbrainCell SpecificEpicardial cells

Function & Pathway

Protein Function

Potential drug targets
Human disease related genes:Immune system diseases:Primary immunodeficiency
Transporters:Transporter channels and pores
Predicted secreted proteins
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M138 Pid thrombin par4 pathway
M155 Pid s1p meta pathway
M268 Pid s1p s1p2 pathway

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Membrane attack complex	C5 C6 C7 C8A C8B C8G C9	P01031 P02748 P07357 P07358 P07360 P10643 P13671	2:1:1:1:1:1:1	SIGNORComplexPortalPDB	PDB:6dlwPDB:6h04PDB:5fmwintact:EBI-25827364PDB:7nycPDB:7nydPDB:6h03SIGNOR:SIGNOR-C313	26841837 26489954 14755292 34667172 30552328
	CLNS1A DDX20 GEMIN2 GEMIN5 NCBP1 RIC8A SMN1 SNRPA1 SNRPD2 SNRPE SNRPF SNRPG	O14893 P09661 P54105 P62304 P62306 P62308 P62316 Q09161 Q16637 Q8TEQ6 Q9NPQ8 Q9UHI6	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4778
	C8A C8B C8G	P07357 P07358 P07360	1:1:1	PDB	PDB:3ojy
	C8A C8G	P07357 P07360	1:1	PDB	PDB:2qosPDB:2rd7
	SLC8A2 SLC8A3	P57103 Q9UPR5	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationSize Exclusion Chromatography	Mass spectrometry	4	32284825 27894104 28590090 33709510

Sequence, Structure & Domains

Sequences

Length

584

Mass

65,163

Sequence

MFAVVFFILSLMTCQPGVTAQEKVNQRVRRAATPAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQCGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDVRAIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDKINVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNRSTITYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC

3D Structural Models

Turn

52..54; 158..161; 183..186; 192..195; 450..452; 503..505

Helix

111..113; 149..152; 201..203; 233..243; 273..280; 312..319; 327..337; 359..365; 369..379; 398..402; 408..413; 428..436; 443..449; 464..470; 477..491; 496..498

Beta Strand

56..60; 63..65; 69..71; 78..83; 97..101; 103..105; 116..118; 121..123; 127..129; 140..143; 154..157; 162..168; 179..182; 189..191; 196..198; 204..207; 212..217; 226..232; 246..252; 260..266; 287..303; 305..308; 339..358; 416..421; 455..463; 508..511; 514..517; 520..523; 525..527; 530..532; 552..554; 556..559; 567..570; 578..582

3D Structure

Electron microscopy (7); X-ray crystallography (4)

Domain & Motif Annotations

Domain (FT)

38..91; TSP type-1 1; 94..132; LDL-receptor class A; 135..498; MACPF; 499..529; EGF-like; 539..583; TSP type-1 2

Region

562..584; Disordered

Protein Families

Complement C6/C7/C8/C9 family

Sequence Similarities

Belongs to the complement C6/C7/C8/C9 family.

Clinical Relevance

Drugs

CARBENOXOLONE OCTANOL CA2+FLUFENAMIC ACID