Protein detail

ACM4

Muscarinic acetylcholine receptor M4

Entry name
ACM4
UniProt ID
P08173
EVMP confidence score
0.53
Supporting publications (n)
4
Transmembrane count
7
Protein classification
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins
Basic Information
Protein Names
Muscarinic acetylcholine receptor M4
Protein Class (3)
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins
Protein Function (2)
  • FDA approved drug targets:Small molecule drugs
  • G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
32..54; Helical; Name=1; 69..89; Helical; Name=2; 107..128; Helical; Name=3; 149..171; Helical; Name=4; 194..216; Helical; Name=5; 402..422; Helical; Name=6; 437..456; Helical; Name=7
Transmembrane Count
7
Ensembl
ENSG00000180720
Entrez Gene Symbol
CHRM4
Gene Description
Cholinergic receptor muscarinic 4
Chromosome
11
Position
46383789-46391776
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificTuft cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (2)
  • FDA approved drug targets:Small molecule drugs
  • G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function
GO:0016907 G protein-coupled acetylcholine receptor activity
Biological Process (3)
KEGG (4)
Reactome (6)
Mediation Categories (2)
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence45

Ligand-Receptor Signaling (40)

40 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_topologyYes
transmembranetransmembraneUniProt_keywordYes
transmembranetransmembraneGO_IntercellYes
transmembranetransmembraneCellPhoneDBYes
transmembranetransmembraneTopDBYes
transmembranetransmembraneLOCATEYes
transmembranetransmembraneRamilowski_locationYes
transmembranetransmembraneOmniPathYes
plasma_membraneplasma_membraneUniProt_locationYes
plasma_membraneplasma_membraneOmniPathYes
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Regulatory Interaction Network (3)

3 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
ACM4P08173GNAI3P08754YesYesWangCui2007SIGNORCA1CA1:7916637CA1:10347206SIGNOR:31160049
ACM4P08173GNAOP09471YesYesHINTSIGNORHINT:36450989SIGNOR:31160049
ACM4P08173GNAI1P63096YesYesHINTSIGNORHINT:35606397SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CHRM4P081732PDBPDB:5dsg

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Mass spectrometry0
Sequence, Structure & Domains

Sequences

Length
479
Mass
53,049
Sequence
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

3D Structural Models

Turn
137..142; 454..456
Helix
34..59; 61..63; 67..83; 85..95; 103..135; 146..174; 188..191; 193..203; 205..222; 226..229; 232..237; 393..425; 432..447; 449..453; 458..462
Beta Strand
175..177; 182..184; 223..225; 427..430
3D Structure
Electron microscopy (17); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias
275..286; Pro residues; 294..304; Polar residues
Region
271..333; Disordered
Protein Families (3)
  • G-protein coupled receptor 1 family
  • Muscarinic acetylcholine receptor subfamily
  • CHRM4 sub-subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases (6)
AsthmaAttention deficit hyperactivity disorderEye anterior segment structural developmental anomalyGlaucomaNausea/vomitingRespiratory system disease
Biomarker
Approved; Investigative
Drug Targets
FDA approved drug targets
Drugs (28)
METHACHOLINE CHLORIDEMETHIXENEXANOMELINEDAROTROPIUM BROMIDEAFACIFENACINMETHOTRIMEPRAZINEVU0010010ATROPINEOLANZAPINEBENZQUINAMIDEDOXEPIN HYDROCHLORIDEPIPERTRAMINE AMIDEPROCYCLIDINETHIETHYLPERAZINEACECLIDINEPROMETHAZINE HYDROCHLORIDEDIPHENIDOLTOLTERODINEMETHYLHOMATROPINETERODILINE HYDROCHLORIDESOFPIRONIUM BROMIDEPROMAZINETROPICAMIDEPROPIOMAZINENULLACLIDINIUMPIPERTRAMINESOLIFENACIN
Antibody (2)
CAB022444HPA072083
Supporting Publications4
PMIDTitleRelated sentences
32854315Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
36064647Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.No related sentences available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
41068253Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.No related sentences available