Protein detail
ACM4
Muscarinic acetylcholine receptor M4
Entry name ACM4 | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Muscarinic acetylcholine receptor M4
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteins
Protein Function
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
32..54; Helical; Name=1; 69..89; Helical; Name=2; 107..128; Helical; Name=3; 149..171; Helical; Name=4; 194..216; Helical; Name=5; 402..422; Helical; Name=6; 437..456; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Description
Cholinergic receptor muscarinic 4
Chromosome
11
Position
46383789-46391776
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificTuft cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ACM4 | P08173 | GNAI3 | P08754 | Yes | Yes | No | WangCui2007SIGNORCA1 | CA1:7916637CA1:10347206SIGNOR:31160049 |
| ACM4 | P08173 | GNAO | P09471 | Yes | Yes | No | HINTSIGNOR | HINT:36450989SIGNOR:31160049 |
| ACM4 | P08173 | GNAI1 | P63096 | Yes | Yes | No | HINTSIGNOR | HINT:35606397SIGNOR:31160049 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
479
Mass
53,049
Sequence
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
3D Structural Models
Turn
137..142; 454..456
Helix
34..59; 61..63; 67..83; 85..95; 103..135; 146..174; 188..191; 193..203; 205..222; 226..229; 232..237; 393..425; 432..447; 449..453; 458..462
Beta Strand
175..177; 182..184; 223..225; 427..430
3D Structure
Electron microscopy (17); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
275..286; Pro residues; 294..304; Polar residues
Region
271..333; Disordered
Protein Families
- G-protein coupled receptor 1 family
- Muscarinic acetylcholine receptor subfamily
- CHRM4 sub-subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Approved; Investigative
Drug Targets
FDA approved drug targets
Drugs
METHACHOLINE CHLORIDEMETHIXENEXANOMELINEDAROTROPIUM BROMIDEAFACIFENACINMETHOTRIMEPRAZINEVU0010010ATROPINEOLANZAPINEBENZQUINAMIDEDOXEPIN HYDROCHLORIDEPIPERTRAMINE AMIDEPROCYCLIDINETHIETHYLPERAZINEACECLIDINEPROMETHAZINE HYDROCHLORIDEDIPHENIDOLTOLTERODINEMETHYLHOMATROPINETERODILINE HYDROCHLORIDESOFPIRONIUM BROMIDEPROMAZINETROPICAMIDEPROPIOMAZINENULLACLIDINIUMPIPERTRAMINESOLIFENACIN