Protein detail

HCK

Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)

Entry name
HCK
UniProt ID
P08631
EVMP confidence score
0.53
Supporting publications (n)
4
Transmembrane count
Protein classification
Disease related genesEnzymesPotential drug targetsPredicted intracellular proteins
Basic Information
Protein Names
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Protein Class (4)
Disease related genesEnzymesPotential drug targetsPredicted intracellular proteins
Protein Function (6)
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Kinases:Tyr protein kinases
  • Disease related genes
Ensembl
ENSG00000101336
Entrez Gene Symbol
HCK
Gene Synonym
JTK9
Gene Description
HCK proto-oncogene, Src family tyrosine kinase
Chromosome
20
Position
32052197-32101856
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
HCK fluorescence
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function (6)
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Kinases:Tyr protein kinases
  • Disease related genes
Cellular Component (12)
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Molecular Function (7)
Biological Process (3)
KEGG (3)
Reactome (22)
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Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence46

Enzyme-Mediated Modification (9)

9 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
HCKCHEK1O14757Y411phosphorylationPhosphoSitePhosphoSite_ProtMapperProtMapper
HCKCSKP41240Y411phosphorylationNCI-PID_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapperProtMapper:16537894ProtMapper:11489946ProtMapper:14967142
HCKCSKP41240Y522phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAKEA:10644735KEA:11976726
HCKAXLP30530Y411phosphorylationPhosphoSitePhosphoSite_ProtMapperProtMapper
HCKGNAI2P04899Y411phosphorylationNCI-PID_ProtMapperProtMapperProtMapper:11160627
HCKPTK2BQ14289Y411phosphorylationNCI-PID_ProtMapperProtMapper
HCKPTPN13Q12923Y411phosphorylationNCI-PID_ProtMapperProtMapperProtMapper:11983165
HCKINSRP06213Y410phosphorylationKEAKEA:17570479
HCKLYNP07948Y410phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling (7)

7 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathYes
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
receptorreceptorscConnectYes

Regulatory Interaction Network (28)

28 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
HCKP08631ABL1P00519YesYesDOMINOSPIKEWangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperHPRDKEAKinexus_KEASPIKE_LCPhosphoSitePhosphoSite_ProtMapperPhosphoSite:24708674SPIKE:18775435ProtMapper:16787943HPRD:10849448SPIKE_LC:20841568DOMINO:10849448ProtMapper:11847100PhosphoSite:26473374ProtMapper:16076903SPIKE:20841568SPIKE_LC:18775435HPRD:9407116ProtMapper:18775435PhosphoSite:28087699SPIKE_LC:10849448KEA:16912036KEA:12522270
HCKP08631CBLP22681YesYesHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEALit-BM-17PhosphoNetworksHPRDWangHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEANetPathSPIKE_LCSPIKEProtMapper:10092522ProtMapper:10799548KEA:9525940HPRD-phos:10092522KEA:10092522HPRD-phos:11239464HPRD:11994282KEA:12604776KEA:10799548Lit-BM-17:8995358SPIKE_LC:8995358KEA:11239464ProtMapper:9890970KEA:11994282ProtMapper:11239464ProtMapper:11994282SPIKE:8995358KEA:10934191SIGNOR:10092522Lit-BM-17:10092522HPRD:10092522Lit-BM-17:11896602NetPath:8995358HPRD-phos:9890970HPRD:11239464HPRD-phos:10799548HPRD-phos:11994282HPRD:9890970KEA:9890970HPRD:10799548iPTMnet:9890970
HCKP08631SHC1P29353YesYesWangSignaLink3TCRcuration_SignaLink3SignaLink3:23109003SignaLink3:10329689
HCKP08631PAXIP49023YesYesSparser_ProtMapperProtMapperSignaLink3WangTCRcuration_SignaLink3SignaLink3:23109003SignaLink3:9636140ProtMapper:16809022
HCKP08631FAK1Q05397YesYesNCI-PID_ProtMapperProtMapperSignaLink3WangLit-BM-17TCRcuration_SignaLink3ProtMapper:12590707SignaLink3:23109003SignaLink3:12495636SignaLink3:9148935SignaLink3:7529876ProtMapper:10753828ProtMapper:11369622Lit-BM-17:25814554SignaLink3:10593973ProtMapper:15728464
HCKP08631FAK2Q14289YesYesKEASignaLink3WangNetworKIN_KEATCRcuration_SignaLink3SignaLink3:23109003SignaLink3:12495636SignaLink3:7529876KEA:17570479SignaLink3:10593973
FAK2Q14289HCKP08631YesYesNCI-PID_ProtMapperProtMapperSignaLink3WangTCRcuration_SignaLink3SignaLink3:23109003SignaLink3:9148935
HCKP08631P85AP27986YesYesWangPhosphoPointHPRDSignaLink3SPIKE_LCTCRcuration_SignaLink3HPRD:12029088SignaLink3:10488096SignaLink3:22880054SignaLink3:11526404SignaLink3:23109003SPIKE_LC:17145710SignaLink3:21780115SignaLink3:15032589
HCKP08631Q96EV4YesSignaLink3TCRcuration_SignaLink3SignaLink3:10488096SignaLink3:22880054SignaLink3:11526404SignaLink3:23109003SignaLink3:21780115SignaLink3:15032589
GNAI1P63096HCKP08631YesYesTCRcuration_SignaLink3SIGNORSignaLink3SignaLink3:10753828SignaLink3:23109003SignaLink3:11007482SIGNOR:11007482SignaLink3:9722546
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
HCKP086312PDBPDB:3vrzPDB:3vryPDB:2c0iPDB:2c0tPDB:3vs6PDB:3vs5PDB:5zj6PDB:1bu1PDB:3vs0PDB:3vs7PDB:2hckPDB:3vs3PDB:3vs1PDB:3vs4PDB:2c0oPDB:1ad5PDB:4luePDB:4ludPDB:3vs2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryR Sequencing130865381
Sequence, Structure & Domains

Sequences

Length
526
Mass
59,600
Sequence
MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
Alternative Products
Event=Alternative splicing, Alternative initiation; Named isoforms=4; Name=1; Synonyms=p60-HCK, p61Hck; IsoId=P08631-1; Sequence=Displayed; Name=2; Synonyms=p59-HCK, p59Hck; IsoId=P08631-2; Sequence=VSP_018858; Name=3; IsoId=P08631-3; Sequence=VSP_018858, VSP_041926; Name=4; IsoId=P08631-4; Sequence=VSP_041926
Alternative Sequence
1..21; Missing (in isoform 2 and isoform 3); 76; Missing (in isoform 3 and isoform 4)

3D Structural Models

Turn
189..191; 252..255; 282..284; 452..454; 513..518
Helix
130..132; 136..138; 139..141; 151..159; 219..228; 259..261; 299..309; 341..345; 350..352; 355..374; 384..386; 402..405; 410..413; 421..423; 426..431; 436..451; 463..471; 484..493; 498..500; 504..512
Beta Strand
82..85; 93..96; 99..102; 104..111; 114..122; 127..129; 133..135; 145..148; 168..172; 174..176; 180..188; 192..202; 204..206; 208..211; 215..218; 233..235; 262..270; 272..281; 285..292; 294..297; 320..324; 326..328; 330..333; 387..389; 395..397; 416..419; 457..460; 480..482; 520..522
3D Structure
NMR spectroscopy (5); X-ray crystallography (35)

Domain & Motif Annotations

Compositional Bias
11..20; Basic and acidic residues
Domain (CC)
The SH3 domain mediates binding to HIV-1 Nef.
Domain (FT)
78..138; SH3; 144..241; SH2; 262..515; Protein kinase
Region
1..20; Disordered
Protein Families (3)
  • Protein kinase superfamily
  • Tyr protein kinase family
  • SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Proto-oncogene
Related Diseases
Indeterminate colitis
Biomarker
Discontinued in Phase 2
Drugs (21)
TG100-801DORAMAPIMODAST-487GEFITINIBENMD-981693PP2DOVITINIBPF-562271ILORASERTIBXL-228MLN-8054MASITINIBCOMPOUND 5B [PMID: 31287314]COMPOUND 5A [PMID: 31287314]HESPERADINIMATINIBBOSUTINIBDASATINIB ANHYDROUSTAMATINIBLIFSLC-0111
Antibody (3)
CAB005195HPA035534HPA063768
Interaction Protein (5)
ENSG00000096384ENSG00000121774ENSG00000143537ENSG00000146648ENSG00000155849
Interaction Count
5
Interaction Dataset
intact_biogrid
Supporting Publications4
PMIDTitleRelated sentences
38037300Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.No related sentences available
39702169iTRAQ proteomic analysis of exosomes derived from synovial fluid reveals disease patterns and potential biomarkers of Osteoarthritis.No related sentences available
40596376Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients.No related sentences available
40689422Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles.No related sentences available