Protein detail
HCK
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Entry name HCK | UniProt ID | EVMP score 0.38 |
Frequency 4 | Transmembrane count | Protein classification Disease related genesEnzymesPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)
Protein Class
Disease related genesEnzymesPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
JTK9
Gene Description
HCK proto-oncogene, Src family tyrosine kinase
Chromosome
20
Position
32052197-32101856
Frequency
4
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
Cellular Component
- GO:0005634 nucleus
- GO:0005764 lysosome
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005884 actin filament
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0005925 focal adhesion
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0030133 transport vesicle
- GO:0042995 cell projection
- GO:0043231 intracellular membrane-bounded organelle
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-9607240 flt3 signaling
- R-hsa-9706374 flt3 signaling through src family kinases
- R-hsa-162906 hiv infection
- R-hsa-162909 host interactions of hiv factors
- R-hsa-9705462 inactivation of csf3 g csf signaling
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-512988 interleukin 3 interleukin 5 and gm csf signaling
- R-hsa-9658195 leishmania infection
- R-hsa-164944 nef and signal transduction
- R-hsa-9664407 parasite infection
- R-hsa-912631 regulation of signaling by cbl
- R-hsa-9680350 signaling by csf1 m csf in myeloid cells
- R-hsa-9674555 signaling by csf3 g csf
- R-hsa-449147 signaling by interleukins
- R-hsa-164952 the role of nef in hiv 1 replication and disease pathogenesis
- R-hsa-9824446 viral infection pathways
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
9 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| HCK | CHEK1 | O14757 | Y | 411 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| HCK | CSK | P41240 | Y | 411 | phosphorylation | NCI-PID_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:16537894ProtMapper:11489946ProtMapper:14967142 |
| HCK | CSK | P41240 | Y | 522 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:10644735KEA:11976726 |
| HCK | AXL | P30530 | Y | 411 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| HCK | GNAI2 | P04899 | Y | 411 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11160627 |
| HCK | PTK2B | Q14289 | Y | 411 | phosphorylation | NCI-PID_ProtMapperProtMapper | |
| HCK | PTPN13 | Q12923 | Y | 411 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11983165 |
| HCK | INSR | P06213 | Y | 410 | phosphorylation | KEA | KEA:17570479 |
| HCK | LYN | P07948 | Y | 410 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
28 records.
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Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryR Sequencing | 1 | 30865381 |
Sequence, Structure & Domains
Sequences
Length
526
Mass
59,600
Sequence
MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
Alternative Products
Event=Alternative splicing, Alternative initiation; Named isoforms=4; Name=1; Synonyms=p60-HCK, p61Hck; IsoId=P08631-1; Sequence=Displayed; Name=2; Synonyms=p59-HCK, p59Hck; IsoId=P08631-2; Sequence=VSP_018858; Name=3; IsoId=P08631-3; Sequence=VSP_018858, VSP_041926; Name=4; IsoId=P08631-4; Sequence=VSP_041926
Alternative Sequence
1..21; Missing (in isoform 2 and isoform 3); 76; Missing (in isoform 3 and isoform 4)
3D Structural Models
Turn
189..191; 252..255; 282..284; 452..454; 513..518
Helix
130..132; 136..138; 139..141; 151..159; 219..228; 259..261; 299..309; 341..345; 350..352; 355..374; 384..386; 402..405; 410..413; 421..423; 426..431; 436..451; 463..471; 484..493; 498..500; 504..512
Beta Strand
82..85; 93..96; 99..102; 104..111; 114..122; 127..129; 133..135; 145..148; 168..172; 174..176; 180..188; 192..202; 204..206; 208..211; 215..218; 233..235; 262..270; 272..281; 285..292; 294..297; 320..324; 326..328; 330..333; 387..389; 395..397; 416..419; 457..460; 480..482; 520..522
3D Structure
NMR spectroscopy (5); X-ray crystallography (35)
Domain & Motif Annotations
Compositional Bias
11..20; Basic and acidic residues
Domain (CC)
The SH3 domain mediates binding to HIV-1 Nef.
Domain (FT)
78..138; SH3; 144..241; SH2; 262..515; Protein kinase
Region
1..20; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- SRC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Clinical Relevance
Disease Involvement
Proto-oncogene
Related Diseases
Biomarker
Discontinued in Phase 2
Drugs
Interaction Protein
ENSG00000096384ENSG00000121774ENSG00000143537ENSG00000146648ENSG00000155849
Interaction Count
5
Interaction Dataset
intact_biogrid