Protein detail

ENOG

Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)

Entry name ENOG	UniProt ID P09104	EVMP score 0.38
Frequency 2	Transmembrane count	Protein classification Cancer-related genesCandidate cardiovascular disease genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)

Protein Class

Cancer-related genesCandidate cardiovascular disease genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
ENZYME proteins:Lyases
Candidate cardiovascular disease genes
Enzymes
Cancer-related genes:Candidate cancer biomarkers

Ensembl

ENSG00000111674

Entrez Gene Symbol

ENO2

Gene Synonym

NSE

Gene Description

Enolase 2

Chromosome

Position

6913745-6923698

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificsalivary glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificastrocyte

Function & Pathway

Protein Function

Predicted intracellular proteins
ENZYME proteins:Lyases
Candidate cardiovascular disease genes
Enzymes
Cancer-related genes:Candidate cancer biomarkers

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Metabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

10 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

11 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ENO2 HK1 NXT1 RAN RANBP1 RANBP3 RCC1 TNPO2 UBC VDAC2 XPO1	O14787 O14980 P09104 P0CG48 P18754 P19367 P43487 P45880 P62826 Q9H6Z4 Q9UKK6	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7158
ENO2 TAX1BP3	O14907 P09104	0:0	hu.MAP2
ENO2 NDUFA12 NDUFS1 NDUFS6 NDUFS7 TMSB4X	O75251 O75380 P09104 P28331 P62328 Q9UI09	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4012
ENO2 HK1 SUMO4 TPM3 TRAP1 UBC VDAC1	P06753 P09104 P0CG48 P19367 P21796 Q12931 Q6EEV6	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4197
ENO2 PPA1 SUMO4 TPM3 TRAP1 UBC VDAC1	P06753 P09104 P0CG48 P21796 Q12931 Q15181 Q6EEV6	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8290
ENO2	P09104	2	PDB	PDB:7mbhPDB:2akzPDB:3uccPDB:5tijPDB:5td9PDB:3ujfPDB:3ujePDB:5eu9PDB:3ucdPDB:3ujsPDB:2akmPDB:5idzPDB:4zcwPDB:1te6PDB:3ujrPDB:4za0
AHCY ENO2 LDHAL6A RPE	P09104 P23526 Q6ZMR3 Q96AT9	0:0:0:0	hu.MAP2
ENO2 FABP5 GPX4 GSTO2	P09104 P36969 Q01469 Q9H4Y5	0:0:0:0	hu.MAP
DYNLRB2 ENO2	P09104 Q8TF09	0:0	hu.MAP2
ENO2 RPE	P09104 Q96AT9	0:0	hu.MAP2

Page 1 of 2Next

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Small R sequencing (Illumi HiSeq 2000 (Solexa)	3	37786918 27894104 33709510

Sequence, Structure & Domains

Sequences

Length

434

Mass

47,269

Sequence

MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09104-1; Sequence=Displayed; Name=2; IsoId=P09104-2; Sequence=VSP_055482

Alternative Sequence

61..104; GVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKS -> A (in isoform 2)

3D Structural Models

Turn

54..56; 104..106; 237..239; 259..262; 319..323

Helix

57..59; 63..71; 73..80; 87..98; 108..126; 130..138; 156..158; 178..200; 202..205; 220..234; 248..251; 267..269; 273..286; 301..309; 325..333; 344..347; 350..362; 380..388; 401..417; 418..420; 425..427; 431..433

Beta Strand

5..12; 18..26; 29..34; 43..45; 100..102; 147..154; 159..162; 167..171; 211..213; 241..245; 254..257; 289..293; 312..318; 338..342; 366..370; 391..394

3D Structure

X-ray crystallography (16)

Domain & Motif Annotations

Protein Families

Enolase family

Sequence Similarities

Belongs to the enolase family.

Clinical Relevance

Disease Involvement

Cancer-related genes

Drugs

PROPOFOL SODIUM BUTYRATE FENRETINIDE LIOTHYRONINE PEXMETINIB ACALABRUTINIB BOSUTINIB STREPTOZOCIN FLOXURIDINE PP1 INDOMETHACIN COMPOUND 2 [PMID: 15546730]COMPOUND 25 [PMID: 31260299]ECF506 INSULIN, REGULAR, HUMAN GABAPENTIN PP2 IBRUTINIB NERVE GROWTH FACTOR

Antibody

CAB000063 HPA068284 HPA068721 CAB073539 CAB079023

Interaction Protein

ENSG00000074800

Interaction Count

Interaction Dataset

intact_biogrid_bioplex