Protein detail
ENOG
Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)
Entry name ENOG | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Cancer-related genesCandidate cardiovascular disease genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gamma-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 2) (Neural enolase) (Neuron-specific enolase) (NSE)
Protein Class
Cancer-related genesCandidate cardiovascular disease genesEnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Lyases
- Candidate cardiovascular disease genes
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
Ensembl
Entrez Gene Symbol
Gene Synonym
NSE
Gene Description
Enolase 2
Chromosome
12
Position
6913745-6923698
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificsalivary glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Lyases
- Candidate cardiovascular disease genes
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
434
Mass
47,269
Sequence
MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09104-1; Sequence=Displayed; Name=2; IsoId=P09104-2; Sequence=VSP_055482
Alternative Sequence
61..104; GVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKS -> A (in isoform 2)
3D Structural Models
Turn
54..56; 104..106; 237..239; 259..262; 319..323
Helix
57..59; 63..71; 73..80; 87..98; 108..126; 130..138; 156..158; 178..200; 202..205; 220..234; 248..251; 267..269; 273..286; 301..309; 325..333; 344..347; 350..362; 380..388; 401..417; 418..420; 425..427; 431..433
Beta Strand
5..12; 18..26; 29..34; 43..45; 100..102; 147..154; 159..162; 167..171; 211..213; 241..245; 254..257; 289..293; 312..318; 338..342; 366..370; 391..394
3D Structure
X-ray crystallography (16)
Domain & Motif Annotations
Protein Families
Enolase family
Sequence Similarities
Belongs to the enolase family.
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs
Interaction Protein
ENSG00000074800
Interaction Count
1
Interaction Dataset
intact_biogrid_bioplex