Protein detail

CD48

CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)

Entry name
CD48
UniProt ID
P09326
EVMP confidence score
0.63
Supporting publications (n)
10
Transmembrane count
Protein classification
CD markersPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)
Protein Class (5)
CD markersPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function (3)
  • Predicted secreted proteins
  • CD markers
  • Transporters:Accessory Factors Involved in Transport
Ensembl
ENSG00000117091
Entrez Gene Symbol
CD48
Gene Synonym (5)
BCM1BLASThCD48mCD48SLAMF2
Gene Description
CD48 molecule
Chromosome
1
Position
160678746-160711831
Supporting publications (n)
10
EVMP confidence score
0.63
Fluorescence & Localization2
CD48 fluorescence
Cell SpecificLate primary spermatocytes
Function & Pathway8
Protein Function (3)
  • Predicted secreted proteins
  • CD markers
  • Transporters:Accessory Factors Involved in Transport
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
KEGG (2)
Reactome (2)
Canonical Pathways (3)
  • M277 Pid integrin a4b1 pathway
  • M3468 Naba ecm regulators
  • M5885 Naba matrisome associated
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence45

Ligand-Receptor Signaling (43)

43 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
icamcell_adhesionZhong2015YesYesYesYesYes
adhesionadhesionOmniPathYesYesYesYesYes
cell_adhesioncell_adhesionOmniPathYesYesYesYesYes
transmembrane_predictedtransmembraneOmniPathNoNoYesYesYes
transmembranetransmembraneCellPhoneDBNoNoYesYesYes
transmembranetransmembraneTopDBNoNoYesYesYes
transmembranetransmembraneLOCATENoNoYesYesYes
transmembranetransmembraneRamilowski_locationNoNoYesYesYes
transmembranetransmembraneOmniPathNoNoYesYesYes
plasma_membraneplasma_membraneUniProt_locationNoNoYesYesYes
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Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CD48PRAP1P09326Q96NZ90:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationWestern blotting22688484137922300
Sequence, Structure & Domains10

Sequences

Length
243
Mass
27,683
Sequence
MCSRGWDSCLALELLLLPLSLLVTSIQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLARSFGVEWIASWLVVTVPTILGLLLT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09326-1; Sequence=Displayed; Name=2; IsoId=P09326-2; Sequence=VSP_055598, VSP_055599
Alternative Sequence
129..169; DPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDK -> GESGEPKSKSPLQWPQMDHCRASWEAWGTLGEEERKTSGQV (in isoform 2); 170..243; Missing (in isoform 2)

3D Structural Models

Turn
80..84; 89..91; 114..116
Helix
101..103
Beta Strand
34..36; 41..43; 51..61; 64..69; 74..76; 94..98; 105..113; 117..120; 126..128
3D Structure
NMR spectroscopy (1)

Domain & Motif Annotations

Domain (FT)
29..127; Ig-like C2-type 1; 132..212; Ig-like C2-type 2
Clinical Relevance1
Antibody (2)
CAB002497HPA055146
Supporting Publications10
PMIDTitleAbstract
32106990Characterization of exosomes in peritoneal fluid of endometriosis patients.No abstract available
36064647Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.No abstract available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No abstract available
38772652High-throughput proteomic analysis of extracellular vesicles from saliva by chemical probe-based array.No abstract available
38895962A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis.No abstract available
39001700Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.No abstract available
39207047The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.No abstract available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No abstract available
40840701Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.No abstract available
40985879TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.No abstract available