Protein detail
CD48
CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)
Entry name CD48 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 10 | Transmembrane count | Protein classification CD markersPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)
Protein Class (5)
CD markersPlasma proteinsPredicted membrane proteinsPredicted secreted proteinsTransporters
Protein Function (3)
- Predicted secreted proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
BCM1BLASThCD48mCD48SLAMF2
Gene Description
CD48 molecule
Chromosome
1
Position
160678746-160711831
Supporting publications (n)
10
EVMP confidence score
0.63
Fluorescence & Localization
Cell SpecificLate primary spermatocytes
Function & Pathway
Protein Function (3)
- Predicted secreted proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
Cellular Component (5)
Molecular Function (2)
Biological Process (3)
Canonical Pathways (3)
- M277 Pid integrin a4b1 pathway
- M3468 Naba ecm regulators
- M5885 Naba matrisome associated
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence45
Ligand-Receptor Signaling (43)
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| icam | cell_adhesion | Zhong2015 | Yes | Yes | Yes | Yes | Yes |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | Yes | Yes |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | Yes | Yes | Yes |
| transmembrane_predicted | transmembrane | OmniPath | Yes | Yes | Yes | ||
| transmembrane | transmembrane | CellPhoneDB | Yes | Yes | Yes | ||
| transmembrane | transmembrane | TopDB | Yes | Yes | Yes | ||
| transmembrane | transmembrane | LOCATE | Yes | Yes | Yes | ||
| transmembrane | transmembrane | Ramilowski_location | Yes | Yes | Yes | ||
| transmembrane | transmembrane | OmniPath | Yes | Yes | Yes | ||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | Yes | Yes |
Protein Complex Composition (1)
Sequence, Structure & Domains
Sequences
Length
243
Mass
27,683
Sequence
MCSRGWDSCLALELLLLPLSLLVTSIQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLARSFGVEWIASWLVVTVPTILGLLLT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P09326-1; Sequence=Displayed; Name=2; IsoId=P09326-2; Sequence=VSP_055598, VSP_055599
Alternative Sequence
129..169; DPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDK -> GESGEPKSKSPLQWPQMDHCRASWEAWGTLGEEERKTSGQV (in isoform 2); 170..243; Missing (in isoform 2)
3D Structural Models
Turn
80..84; 89..91; 114..116
Helix
101..103
Beta Strand
34..36; 41..43; 51..61; 64..69; 74..76; 94..98; 105..113; 117..120; 126..128
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Domain (FT)
29..127; Ig-like C2-type 1; 132..212; Ig-like C2-type 2
Supporting Publications10
| PMID | Title | Related sentences |
|---|---|---|
| 32106990 | Characterization of exosomes in peritoneal fluid of endometriosis patients. | No related sentences available |
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38772652 | High-throughput proteomic analysis of extracellular vesicles from saliva by chemical probe-based array. | No related sentences available |
| 38895962 | A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis. | No related sentences available |
| 39001700 | Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles. | No related sentences available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No related sentences available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No related sentences available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No related sentences available |
| 40985879 | TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. | No related sentences available |