Protein detail

CN37

2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)

Entry name CN37	UniProt ID P09543	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Ensembl

ENSG00000173786

Entrez Gene Symbol

CNP

Gene Description

2',3'-cyclic nucleotide 3' phosphodiesterase

Chromosome

Position

41966763-41977740

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Cellular Component (14)

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Molecular Function (4)

Biological Process (3)

Mediation Categories

Immune mediation

Relations & Evidence40

Enzyme-Mediated Modification (6)

6 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CNP	PRKCA	P17252	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	PRKCB	P05771	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	PRKCG	P05129	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	PRKCD	Q05655	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	PRKCE	Q02156	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	RPS6KA3	P51812	S	22	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CN37	P09543	MBP	P02686	Yes	No	Yes	SIGNOR	SIGNOR:28076777

Protein Complex Composition (25)

25 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster447	CNPY3 CNPY4 CTRB1 CTRB2 CTRL	P17538 P40313 Q6GPI1 Q8N129 Q9BT09	1:1:1:1:1	Compleat	Compleat:HC3491	22036573
	CNPY2 DNAH10 PDIA5 WDR81 WDR91 WFDC2	A4D1P6 Q14508 Q14554 Q562E7 Q8IVF4 Q9Y2B0	0:0:0:0:0:0	hu.MAP2
	CNPPD1 GYG1 GYG2 GYS1 GYS2 PGRMC1	O00264 O15488 P13807 P46976 P54840 Q9BV87	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7520
	CHAD CNPY4 EID2 KERA LRRTM2 PODN	O15335 O43300 O60938 Q7Z5L7 Q8N129 Q8N6I1	0:0:0:0:0:0	hu.MAP2
	CHAD CNPY4 LRRTM2 PODN	O15335 O43300 Q7Z5L7 Q8N129	0:0:0:0	hu.MAP2
	CHAD CNPY4 KERA PODN	O15335 O60938 Q7Z5L7 Q8N129	0:0:0:0	hu.MAP2
	CHAD CNPY4	O15335 Q8N129	0:0	hu.MAPhu.MAP2
	CNPPD1 GYG1 GYG2 GYS1 PPP1CC PPP1R3A PPP1R3D	O15488 O95685 P13807 P36873 P46976 Q16821 Q9BV87	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4814
	CDK18 CNPPD1 GYG1 GYG2 GYS1 GYS2 UBC	O15488 P0CG48 P13807 P46976 P54840 Q07002 Q9BV87	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4189
	CNPY3 LRRC40 LRRTM2 OGN	O43300 P20774 Q9BT09 Q9H9A6	0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	1	38113368

Sequence, Structure & Domains11

Sequences

Length

421

Mass

47,579

Sequence

MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGKGKPVPTQGSRKGGALQSCTII

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=CNPII; Synonyms=DNAII; IsoId=P09543-1; Sequence=Displayed; Name=CNPI; Synonyms=DNAI; IsoId=P09543-2; Sequence=VSP_004171

Alternative Sequence

1..20; Missing (in isoform CNPI)

3D Structural Models

Turn

325..328

Helix

196..215; 217..221; 223..226; 238..241; 258..260; 265..270; 272..277; 306..309; 343..356

Beta Strand

188..194; 251..256; 281..291; 293..301; 330..335; 362..367; 370..376; 379..397

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Protein Families (2)

2H phosphoesterase superfamily
CNPase family

Sequence Similarities

Belongs to the 2H phosphoesterase superfamily. CNPase family.

Clinical Relevance2

Disease Involvement (2)

LeukodystrophyNeurodegeneration

Antibody (5)

CAB002672 HPA023266 HPA023278 HPA023280 HPA023338

Supporting Publications1

PMID	Title	Abstract
40730843	Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.	No abstract available