Protein detail

CN37

2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)

Entry name
CN37
UniProt ID
P09543
EVMP confidence score
0.50
Supporting publications (n)
1
Transmembrane count
Protein classification
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information10
Protein Names
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (6)
  • Predicted intracellular proteins
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
  • Potential drug targets
  • Enzymes
  • ENZYME proteins:Hydrolases
  • Disease related genes
Ensembl
ENSG00000173786
Entrez Gene Symbol
CNP
Gene Description
2',3'-cyclic nucleotide 3' phosphodiesterase
Chromosome
17
Position
41966763-41977740
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway5
Protein Function (6)
  • Predicted intracellular proteins
  • Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
  • Potential drug targets
  • Enzymes
  • ENZYME proteins:Hydrolases
  • Disease related genes
Cellular Component (14)
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Molecular Function (4)
Biological Process (3)
Mediation Categories
Immune mediation
Relations & Evidence40

Enzyme-Mediated Modification (6)

6 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
CNPPRKCAP17252S9phosphorylationMIMPphosphoELM_MIMPPhosphoSite_MIMP
CNPPRKCBP05771S9phosphorylationMIMPphosphoELM_MIMPPhosphoSite_MIMP
CNPPRKCGP05129S9phosphorylationMIMPphosphoELM_MIMPPhosphoSite_MIMP
CNPPRKCDQ05655S9phosphorylationMIMPphosphoELM_MIMPPhosphoSite_MIMP
CNPPRKCEQ02156S9phosphorylationMIMPphosphoELM_MIMPPhosphoSite_MIMP
CNPRPS6KA3P51812S22phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling (7)

7 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecmecmMatrixDBYesNoNoNoNo
ecmecmOmniPathYesNoNoNoNo
extracellularextracellularOmniPathNoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
CN37P09543MBPP02686YesNoYesSIGNORSIGNOR:28076777

Protein Complex Composition (25)

25 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CCNA2CCNB1CCNB2CCND2CDC20CDC23CDC27CDC6CDK1CDK2CKS1BCKS2CNPPD1FZR1UBCO95067P06493P0CG48P14635P20248P24941P30260P30279P33552P61024Q12834Q99741Q9BV87Q9UJX2Q9UM111:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC6972
CCNA2CCNB1CCNB2CCND2CDC6CDK1CDK2CDK6CKS1BCKS2CNPPD1LPIN1UBCO95067P06493P0CG48P14635P20248P24941P30279P33552P61024Q00534Q14693Q99741Q9BV871:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC9029
CCNA2CCNE1CCNE2CDC25ACDK1CDK2CDK3CDKN3CKS1BCKS2CNPPD1UBCO96020P06493P0CG48P20248P24864P24941P30304P33552P61024Q00526Q16667Q9BV871:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC8603
CNPY2PSAPP07602Q9Y2B00:0hu.MAP
CCAR1HDGFL2NSRP1PCNPPPIL4RBM10RBM17RBM5SCAF8P0DW28P52756Q7Z4V5Q8IX12Q8WUA2Q8WW12Q96I25Q9H0G5Q9UPN60:0:0:0:0:0:0:0:0hu.MAP
HDGFL2NSRP1PCNPPPIL4RBM10RBM17RBM5P0DW28P52756Q7Z4V5Q8WUA2Q8WW12Q96I25Q9H0G50:0:0:0:0:0:0hu.MAP
NSRP1PCNPRBM10RBM5P0DW28P52756Q8WW12Q9H0G50:0:0:0hu.MAP
CNPY2FXR2GCSHP23434P51116Q9Y2B00:0:0hu.MAP2
CNPY3LRRC40LUMP51884Q9BT09Q9H9A60:0:0hu.MAP2
CCAR1HDGFL2NSRP1PCNPPPIL4RBM10RBM17RBM5SCAF8P52756P98175Q7Z4V5Q8IX12Q8WUA2Q8WW12Q96I25Q9H0G5Q9UPN60:0:0:0:0:0:0:0:0hu.MAP
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometry138113368
Sequence, Structure & Domains11

Sequences

Length
421
Mass
47,579
Sequence
MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGKGKPVPTQGSRKGGALQSCTII
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=CNPII; Synonyms=DNAII; IsoId=P09543-1; Sequence=Displayed; Name=CNPI; Synonyms=DNAI; IsoId=P09543-2; Sequence=VSP_004171
Alternative Sequence
1..20; Missing (in isoform CNPI)

3D Structural Models

Turn
325..328
Helix
196..215; 217..221; 223..226; 238..241; 258..260; 265..270; 272..277; 306..309; 343..356
Beta Strand
188..194; 251..256; 281..291; 293..301; 330..335; 362..367; 370..376; 379..397
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Protein Families (2)
  • 2H phosphoesterase superfamily
  • CNPase family
Sequence Similarities
Belongs to the 2H phosphoesterase superfamily. CNPase family.
Clinical Relevance2
Disease Involvement (2)
LeukodystrophyNeurodegeneration
Antibody (5)
CAB002672HPA023266HPA023278HPA023280HPA023338
Supporting Publications1
PMIDTitleAbstract
40730843Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.No abstract available