Protein detail

CN37

2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)

Protein symbol CN37	UniProt ID P09543	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)

Protein Class

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Ensembl

ENSG00000173786

Entrez Gene Symbol

CNP

Gene Description

2',3'-cyclic nucleotide 3' phosphodiesterase

Chromosome

Position

41966763-41977740

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Disease related genes

Cellular Component

Molecular Function

Biological Process

Mediation Categories

Immune mediation

Relations & Evidence

Enzyme-Mediated Modification

6 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CNP	PRKCA	P17252	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	PRKCB	P05771	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	PRKCG	P05129	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	PRKCD	Q05655	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	PRKCE	Q02156	S	9	phosphorylation	MIMPphosphoELM_MIMPPhosphoSite_MIMP
CNP	RPS6KA3	P51812	S	22	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CN37	P09543	MBP	P02686	Yes	No	Yes	SIGNOR	SIGNOR:28076777

Protein Complex Composition

25 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CCNA2 CCNB1 CCNB2 CCND2 CDC20 CDC23 CDC27 CDC6 CDK1 CDK2 CKS1B CKS2 CNPPD1 FZR1 UBC	O95067 P06493 P0CG48 P14635 P20248 P24941 P30260 P30279 P33552 P61024 Q12834 Q99741 Q9BV87 Q9UJX2 Q9UM11	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6972
CCNA2 CCNB1 CCNB2 CCND2 CDC6 CDK1 CDK2 CDK6 CKS1B CKS2 CNPPD1 LPIN1 UBC	O95067 P06493 P0CG48 P14635 P20248 P24941 P30279 P33552 P61024 Q00534 Q14693 Q99741 Q9BV87	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9029
CCNA2 CCNE1 CCNE2 CDC25A CDK1 CDK2 CDK3 CDKN3 CKS1B CKS2 CNPPD1 UBC	O96020 P06493 P0CG48 P20248 P24864 P24941 P30304 P33552 P61024 Q00526 Q16667 Q9BV87	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8603
CNPY2 PSAP	P07602 Q9Y2B0	0:0	hu.MAP
CCAR1 HDGFL2 NSRP1 PCNP PPIL4 RBM10 RBM17 RBM5 SCAF8	P0DW28 P52756 Q7Z4V5 Q8IX12 Q8WUA2 Q8WW12 Q96I25 Q9H0G5 Q9UPN6	0:0:0:0:0:0:0:0:0	hu.MAP
HDGFL2 NSRP1 PCNP PPIL4 RBM10 RBM17 RBM5	P0DW28 P52756 Q7Z4V5 Q8WUA2 Q8WW12 Q96I25 Q9H0G5	0:0:0:0:0:0:0	hu.MAP
NSRP1 PCNP RBM10 RBM5	P0DW28 P52756 Q8WW12 Q9H0G5	0:0:0:0	hu.MAP
CNPY2 FXR2 GCSH	P23434 P51116 Q9Y2B0	0:0:0	hu.MAP2
CNPY3 LRRC40 LUM	P51884 Q9BT09 Q9H9A6	0:0:0	hu.MAP2
CCAR1 HDGFL2 NSRP1 PCNP PPIL4 RBM10 RBM17 RBM5 SCAF8	P52756 P98175 Q7Z4V5 Q8IX12 Q8WUA2 Q8WW12 Q96I25 Q9H0G5 Q9UPN6	0:0:0:0:0:0:0:0:0	hu.MAP

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	1	38113368

Sequence, Structure & Domains

Sequences

Length

421

Mass

47,579

Sequence

MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGKGKPVPTQGSRKGGALQSCTII

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=CNPII; Synonyms=DNAII; IsoId=P09543-1; Sequence=Displayed; Name=CNPI; Synonyms=DNAI; IsoId=P09543-2; Sequence=VSP_004171

Alternative Sequence

1..20; Missing (in isoform CNPI)

3D Structural Models

Turn

325..328

Helix

196..215; 217..221; 223..226; 238..241; 258..260; 265..270; 272..277; 306..309; 343..356

Beta Strand

188..194; 251..256; 281..291; 293..301; 330..335; 362..367; 370..376; 379..397

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

2H phosphoesterase superfamily
CNPase family

Sequence Similarities

Belongs to the 2H phosphoesterase superfamily. CNPase family.

Clinical Relevance

Disease Involvement

LeukodystrophyNeurodegeneration

Antibody

CAB002672 HPA023266 HPA023278 HPA023280 HPA023338