Protein detail
CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)
Protein symbol CN37 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Description
2',3'-cyclic nucleotide 3' phosphodiesterase
Chromosome
17
Position
41966763-41977740
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
Cellular Component
- GO:0005615 extracellular space
- GO:0005737 cytoplasm
- GO:0005741 mitochondrial outer membrane
- GO:0005743 mitochondrial inner membrane
- GO:0005874 microtubule
- GO:0005902 microvillus
- GO:0016020 membrane
- GO:0031143 pseudopodium
- GO:0035748 myelin sheath abaxonal region
- GO:0035749 myelin sheath adaxonal region
- GO:0042470 melanosome
- GO:0045202 synapse
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
Molecular Function
Biological Process
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CNP | PRKCA | P17252 | S | 9 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CNP | PRKCB | P05771 | S | 9 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CNP | PRKCG | P05129 | S | 9 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CNP | PRKCD | Q05655 | S | 9 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CNP | PRKCE | Q02156 | S | 9 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CNP | RPS6KA3 | P51812 | S | 22 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CN37 | P09543 | MBP | P02686 | Yes | No | Yes | SIGNOR | SIGNOR:28076777 |
Protein Complex Composition
25 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HDGFL2NSRP1PCNPPPIL4RBM10RBM17RBM5 | P52756P98175Q7Z4V5Q8WUA2Q8WW12Q96I25Q9H0G5 | 0:0:0:0:0:0:0 | hu.MAP | |||
| NSRP1PCNPRBM10RBM5 | P52756P98175Q8WW12Q9H0G5 | 0:0:0:0 | hu.MAP | |||
| NSRP1PCNPRBM5 | P52756Q8WW12Q9H0G5 | 0:0:0 | hu.MAP | |||
| PCNPQKI | Q8WW12Q96PU8 | 0:0 | hu.MAP2 | |||
| CNPY3LRRC40 | Q9BT09Q9H9A6 | 0:0 | hu.MAP |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometry | 1 | 38113368 |
Sequence, Structure & Domains
Sequences
Length
421
Mass
47,579
Sequence
MNRGFSRKSHTFLPKIFFRKMSSSGAKDKPELQFPFLQDEDTVATLLECKTLFILRGLPGSGKSTLARVIVDKYRDGTKMVSADAYKITPGARGAFSEEYKRLDEDLAAYCRRRDIRILVLDDTNHERERLEQLFEMADQYQYQVVLVEPKTAWRLDCAQLKEKNQWQLSADDLKKLKPGLEKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRQFVPGDEPREKMDLVTYFGKRPPGVLHCTTKFCDYGKAPGAEEYAQQDVLKKSYSKAFTLTISALFVTPKTTGARVELSEQQLQLWPSDVDKLSPTDNLPRGSRAHITLGCAADVEAVQTGLDLLEILRQEKGGSRGEEVGELSRGKLYSLGNGRWMLTLAKNMEVRAIFTGYYGKGKPVPTQGSRKGGALQSCTII
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=CNPII; Synonyms=DNAII; IsoId=P09543-1; Sequence=Displayed; Name=CNPI; Synonyms=DNAI; IsoId=P09543-2; Sequence=VSP_004171
Alternative Sequence
1..20; Missing (in isoform CNPI)
3D Structural Models
Turn
325..328
Helix
196..215; 217..221; 223..226; 238..241; 258..260; 265..270; 272..277; 306..309; 343..356
Beta Strand
188..194; 251..256; 281..291; 293..301; 330..335; 362..367; 370..376; 379..397
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
- 2H phosphoesterase superfamily
- CNPase family
Sequence Similarities
Belongs to the 2H phosphoesterase superfamily. CNPase family.