Protein detail

TAU

Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

Protein symbol
TAU
UniProt ID
EVMP score
0.50
Frequency
3
Transmembrane count
Protein classification
Candidate cardiovascular disease genesDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Basic Information
Protein Names
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Protein Class
Candidate cardiovascular disease genesDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
  • Predicted intracellular proteins
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • Candidate cardiovascular disease genes
  • Predicted secreted proteins
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Entrez Gene Symbol
Gene Synonym
DDPACFLJ31424FTDP-17MAPTLMGC138549MSTDMTBT1MTBT2PPNDPPP1R103tautau-40
Gene Description
Microtubule associated protein tau
Chromosome
17
Position
45894527-46028334
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificEsophageal apical cells
Function & Pathway
Protein Function
  • Predicted intracellular proteins
  • Human disease related genes:Nervous system diseases:Neurodegenerative diseases
  • Candidate cardiovascular disease genes
  • Predicted secreted proteins
  • Disease related genes
  • FDA approved drug targets:Small molecule drugs
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

1,054 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
MAPTPRKACAP17612S324phosphorylationPhosphoSite
MAPTGSK3BP49841S530phosphorylationMIMPHPRD_MIMPPhosphoSite_MIMP
MAPTGSK3BP49841S533phosphorylationMIMPHPRD_MIMPPhosphoSite_MIMP
MAPTPRKACAP17612S316phosphorylationPhosphoSite
MAPTPRKACAP17612S293phosphorylationPhosphoSite
MAPTGSK3BP49841S534phosphorylationMIMPHPRD_MIMPPhosphoSite_MIMP
MAPTGSK3BP49841S554phosphorylationPhosphoNetworks
MAPTGSK3BP49841S637phosphorylationPhosphoNetworks
MAPTGSK3BP49841S726phosphorylationPhosphoNetworks
MAPTGSK3BP49841T548phosphorylationPhosphoNetworksSparser_ProtMapperSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperKEA:9353289ProtMapper:22690349HPRD:9832145KEA:7566346HPRD:17287340SIGNOR:12387894KEA:9771888HPRD:9735171KEA:9735171SIGNOR:21215781ProtMapper:29725295ProtMapper:22278060KEA:9199504phosphoELM:9565682ProtMapper:21215781HPRD:7566346HPRD:19651622HPRD:20068231ProtMapper:12387894KEA:12387894KEA:9832145HPRD:12387894ProtMapper:14690523HPRD:9565682HPRD:9199504ProtMapper:17047304HPRD:9771888HPRD:9353289KEA:9565682
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Ligand-Receptor Signaling

13 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
extracellularextracellularOmniPathNoNoYesNoNo
intracellularintracellularLOCATENoNoYesNoNo
intracellularintracellularComPPINoNoYesNoNo
intracellularintracellularGO_IntercellNoNoYesNoNo
intracellularintracellularUniProt_locationNoNoYesNoNo
intracellularintracellularOmniPathNoNoYesNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoYesNoNo
plasma_membraneplasma_membraneOmniPathNoNoYesNoNo
secretedsecretedUniProt_keywordNoNoYesNoNo
secretedsecretedUniProt_locationNoNoYesNoNo
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Regulatory Interaction Network

50 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
GSK3BP49841TAUP10636YesYesYesSPIKEKEGG-MEDICUSHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAphosphoELM_KEAInnateDBPhosphoNetworksNCI-PID_ProtMapperHPRDCui2007IntActWangNetworKIN_KEABEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEABioGRIDHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperSPIKE_LCHPRD-phosKEA:15302935KEA:9353289HPRD-phos:9199504HPRD-phos:19415658ProtMapper:19616957ProtMapper:18627032KEA:8999860ProtMapper:20049527KEA:7566346ProtMapper:28386764SIGNOR:12387894phosphoELM:12714590HINT:16446437KEA:11104762KEA:1330687ProtMapper:19562805InnateDB:15522877ProtMapper:23333093ProtMapper:9565682KEA:9199504IntAct:17078951KEA:12387897ProtMapper:7566346HINT:21985244BioGRID:15542598HPRD:7566346KEA:7706316HPRD-phos:11311121ProtMapper:32046944ProtMapper:10737616ProtMapper:12226093ProtMapper:24268883HINT:16519507KEA:11181841ProtMapper:29570615ProtMapper:21865886HPRD-phos:12387897ProtMapper:27965573HPRD:17078951InnateDB:15073173HINT:9771888ProtMapper:9716264iPTMnet:9614189ProtMapper:29381861ProtMapper:17078951HINT:31640277ProtMapper:1330687SIGNOR:17078951HPRD-phos:11181841ProtMapper:29191219KEA:2387894HPRD-phos:12387894ProtMapper:24165324ProtMapper:28379300SIGNOR:20679343HINT:19014373HINT:17512525HPRD-phos:9771888KEA:12714590ProtMapper:10090741ProtMapper:21215781HPRD-phos:12435421SIGNOR:9832145HINT:12387894ProtMapper:25219467ProtMapper:12387897ProtMapper:16420965ProtMapper:12387894ProtMapper:18510355ProtMapper:24646911KEA:12435421HINT:16519508HPRD-phos:17287340ProtMapper:20068231HINT:14612456HPRD:9771888HINT:9546672ProtMapper:12435421ProtMapper:25641096HPRD-phos:7566346ProtMapper:11311121HPRD:9832145KEA:10090741ProtMapper:25192600IntAct:24165324HPRD:11181841HINT:16365045ProtMapper:19413330SPIKE_LC:17078951HINT:17045592HPRD-phos:9353289HINT:12048243KEA:12226093KEA:17078951HINT:18467332ProtMapper:11181841KEA:9546672ProtMapper:29725295HPRD-phos:20068231ProtMapper:29704550HPRD-phos:9565682HINT:10090741IntAct:31640277ProtMapper:29408874ProtMapper:21671254HPRD-phos:9735171KEA:1181841phosphoELM:9565682SPIKE_LC:16568235ProtMapper:23036273iPTMnet:7706316KEA:11311121SPIKE:16568235ProtMapper:19651622ProtMapper:28734998ProtMapper:9353289HPRD-phos:1330687ProtMapper:25815351HPRD-phos:9546672KEA:12387894HINT:9614189ProtMapper:14690523ProtMapper:27073700ProtMapper:9199504ProtMapper:25352339ProtMapper:31640277ProtMapper:1181841ProtMapper:30890929HPRD-phos:19413330HPRD-phos:9832145ProtMapper:20308788KEA:17570479ProtMapper:22690349HPRD-phos:12226093ProtMapper:28835279ProtMapper:8999860HINT:15542598ProtMapper:9832145ProtMapper:19415658ProtMapper:9735171ProtMapper:17045592ProtMapper:29298849ProtMapper:27349344HINT:9735171KEA:9771888KEA:9735171SIGNOR:21215781SIGNOR:9771888ProtMapper:33895139IntAct:21985244ProtMapper:22278060ProtMapper:7706316ProtMapper:20679343HPRD-phos:18510355ProtMapper:32714591SIGNOR:21443865ProtMapper:32019113ProtMapper:27078700ProtMapper:27857758ProtMapper:9546672HPRD-phos:19562805ProtMapper:17287340KEA:9832145ProtMapper:10601262HPRD-phos:17078951HPRD:9199504HINT:19527721ProtMapper:9771888ProtMapper:17047304ProtMapper:16519507SIGNOR:20308788ProtMapper:33967735ProtMapper:24704314HPRD-phos:19651622KEA:9565682HINT:17078951ProtMapper:16452634
CDK5Q00535TAUP10636YesYesYesKEGG-MEDICUSHPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAHPRDCui2007CA1WangHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperSPIKE_LCSPIKEKEA:15302935KEA:9353289HPRD-phos:9199504HPRD-phos:19415658KEA:7566346ProtMapper:34814918SIGNOR:12387894KEA:11104762KEA:1330687ProtMapper:19562805ProtMapper:9565682CA1:7592534KEA:9199504ProtMapper:24367683ProtMapper:7566346SIGNOR:12226093HPRD:7566346ProtMapper:12226093ProtMapper:24268883KEA:11181841ProtMapper:20508838ProtMapper:9614189ProtMapper:22761989iPTMnet:9614189HPRD:17078951ProtMapper:17078951HINT:9353289HPRD-phos:11181841KEA:2387894HPRD-phos:12387894HINT:17078951HPRD-phos:9771888ProtMapper:21215781HPRD-phos:12435421HINT:12387894ProtMapper:15843619ProtMapper:12071639HINT:11943163KEA:9614189ProtMapper:28785087ProtMapper:12387894HPRD:12387894ProtMapper:18510355ProtMapper:24646911KEA:12435421ProtMapper:16697218HINT:16519508HPRD-phos:17287340ProtMapper:20068231HPRD:9771888ProtMapper:31065832ProtMapper:12435421HPRD-phos:11104762ProtMapper:21945393HPRD-phos:7566346ProtMapper:11311121HPRD:9832145HPRD:11181841ProtMapper:19413330SPIKE_LC:17078951HINT:17045592HPRD-phos:9353289KEA:12226093KEA:17078951ProtMapper:11181841KEA:9546672HPRD-phos:20068231HPRD-phos:9565682ProtMapper:21671254HPRD-phos:9735171KEA:1181841SPIKE_LC:16568235KEA:11311121SPIKE:16568235ProtMapper:19651622ProtMapper:9353289HPRD-phos:1330687HPRD-phos:9546672KEA:12387894HINT:9614189HPRD:9565682ProtMapper:9199504ProtMapper:1181841HPRD-phos:19413330HPRD-phos:9832145ProtMapper:31698798ProtMapper:27641626ProtMapper:26944284HPRD-phos:12226093ProtMapper:9832145ProtMapper:19415658ProtMapper:9735171ProtMapper:17045592HINT:9735171ProtMapper:11104762KEA:9771888KEA:9735171SIGNOR:21215781HPRD-phos:18510355ProtMapper:11086171HINT:16262633HPRD-phos:19562805ProtMapper:9546672ProtMapper:33809910ProtMapper:17287340CA1:8282104ProtMapper:21848865KEA:9832145HPRD-phos:17078951HPRD:9199504HINT:19527721HPRD:1181841ProtMapper:9771888HPRD-phos:19651622KEA:9565682ProtMapper:1330687
MARK2Q7KZI7TAUP10636YesNoYesWangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPiPTMnetSIGNORProtMapperREACH_ProtMapperBioGRIDIntActSPIKE_LCLit-BM-17SPIKELit-BM-17:23666762IntAct:23001711ProtMapper:28066266SIGNOR:10090741ProtMapper:22952452Lit-BM-17:23001711ProtMapper:17573348BioGRID:23001711ProtMapper:7706316ProtMapper:24860424IntAct:23666762SPIKE:9108484ProtMapper:21629754ProtMapper:30287790ProtMapper:20067632SPIKE_LC:9108484Lit-BM-17:24251416
MARK1Q9P0L2TAUP10636YesNoYesHPRD_MIMPSIGNORProtMapperdbPTMHINTPhosphoSite_KEALit-BM-17HPRDphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEABioGRIDHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LCSPIKEKEA:10737616ProtMapper:28222093PhosphoSite:25918155HPRD:9832145KEA:8999860PhosphoSite:8318230KEA:10090741PhosphoSite:20706749HINT:21985311ProtMapper:21776376ProtMapper:27875990ProtMapper:8999860dbPTM:15822905ProtMapper:9832145SPIKE_LC:7706316ProtMapper:9735171PhosphoSite:26858248Lit-BM-17:8631898PhosphoSite:30734106PhosphoSite:16606369KEA:9771888PhosphoSite:33649324SIGNOR:10090741HPRD:12435421HPRD:9735171KEA:9735171ProtMapper:32443670SIGNOR:21215781dbPTM:19451179Lit-BM-17:10090741dbPTM:19413330ProtMapper:12435421HPRD:10090741HINT:10090741ProtMapper:7706316HINT:8631898SPIKE:7706316ProtMapper:10090741PhosphoSite:34560101ProtMapper:21215781HINT:23666762Lit-BM-17:23666762ProtMapper:24533944KEA:7706316iPTMnet:7706316dbPTM:8999860ProtMapper:10737616ProtMapper:26834532KEA:7931292ProtMapper:7931292ProtMapper:12387894KEA:12387894HINT:9614189HPRD:12387894KEA:9832145HPRD:7931292ProtMapper:9771888PhosphoSite:18949077PhosphoSite:34517222KEA:12435421HPRD:10737616PhosphoSite:33895139HPRD:7706316iPTMnet:9614189HPRD:9771888dbPTM:16443603BioGRID:8631898ProtMapper:11172803HPRD:8999860
KAPCAP17612TAUP10636YesYesYesHPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEACui2007CA1WangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteHPRD-phosHINT:21127069KEA:9353289HPRD-phos:9199504KEA:8999860KEA:7566346KEA:11104762ProtMapper:19562805ProtMapper:9565682HINT:23962722KEA:9199504ProtMapper:7566346PhosphoSite:16923168KEA:7706316HINT:12435421ProtMapper:10737616ProtMapper:12226093SIGNOR:12435421CA1:1730702KEA:11181841PhosphoSite:16000144ProtMapper:9614189HINT:9771888SIGNOR:9614189KEA:10737616HPRD-phos:11181841KEA:2387894HPRD-phos:12387894HINT:19014373HPRD-phos:9771888ProtMapper:10090741ProtMapper:21215781HPRD-phos:12435421KEA:9614189ProtMapper:12387894KEA:12435421HPRD-phos:17287340ProtMapper:20068231HINT:9546672ProtMapper:12435421CA1:6412713HPRD-phos:11104762PhosphoSite:12435421HPRD-phos:7566346ProtMapper:11311121KEA:10090741PhosphoSite:8163474ProtMapper:19413330HINT:17045592HPRD-phos:9353289KEA:12226093ProtMapper:11181841KEA:9546672HPRD-phos:20068231HPRD-phos:9565682HINT:10090741HINT:10840038HPRD-phos:9735171iPTMnet:7706316KEA:11311121ProtMapper:19651622ProtMapper:9353289HPRD-phos:9546672KEA:12387894ProtMapper:9199504HPRD-phos:19413330HPRD-phos:9832145ProtMapper:26840030HPRD-phos:12226093ProtMapper:8999860ProtMapper:9832145ProtMapper:9735171ProtMapper:11104762KEA:9771888KEA:9735171SIGNOR:21215781SIGNOR:9771888ProtMapper:7706316ProtMapper:9546672HPRD-phos:19562805ProtMapper:17287340KEA:9832145ProtMapper:9771888HPRD-phos:19651622KEA:9565682
CAN1P07384TAUP10636YesNoYesWangCui2007SIGNORCA1CA1:1730702SIGNOR:25969760
MK01P28482TAUP10636YesYesYesHPRD_MIMPSIGNORProtMapperPhosphoSite_KEACui2007CA1WangphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperHPRD-phosKEA:15302935KEA:10737616PhosphoSite:12414518HPRD-phos:9199504HPRD-phos:19415658HPRD-phos:7566346HPRD-phos:12226093PhosphoSite:18315566HPRD-phos:11181841PhosphoSite:33952699PhosphoSite:9716264HPRD-phos:12387894PhosphoSite:12801934KEA:7566346PhosphoSite:15542598PhosphoSite:16165272PhosphoSite:33961674ProtMapper:19415658ProtMapper:9832145PhosphoSite:24116116PhosphoSite:29298849PhosphoSite:25573097ProtMapper:19413330ProtMapper:30884818KEA:9771888PhosphoSite:34480088PhosphoSite:15324364PhosphoSite:29760653KEA:12226093KEA:1330687ProtMapper:9565682ProtMapper:11181841CA1:8166686PhosphoSite:16115884HPRD-phos:9565682KEA:9199504HPRD-phos:9771888PhosphoSite:31065832HPRD-phos:18510355ProtMapper:7566346PhosphoSite:24301651PhosphoSite:21731772ProtMapper:10737616ProtMapper:12226093CA1:7488031HPRD-phos:1330687ProtMapper:12387894KEA:11181841KEA:12387894SIGNOR:10737616KEA:9832145PhosphoSite:12765608PhosphoSite:18055457PhosphoSite:34536819ProtMapper:18510355ProtMapper:28066266ProtMapper:9771888ProtMapper:9199504PhosphoSite:12766916PhosphoSite:15883264PhosphoSite:34493616iPTMnet:9614189HPRD-phos:19413330PhosphoSite:34854540HPRD-phos:9832145PhosphoSite:31178717KEA:9565682ProtMapper:1330687
DYR1AQ13627TAUP10636YesNoYesWangSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperCui2007HINTBioGRIDCA1SIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteProtMapper:21156028ProtMapper:30332805PhosphoSite:26692334ProtMapper:25730262PhosphoSite:12533609PhosphoSite:11943712PhosphoSite:10818091ProtMapper:24312003ProtMapper:28386764ProtMapper:18696092PhosphoSite:26161867PhosphoSite:25355317ProtMapper:28779511PhosphoSite:34314701ProtMapper:19995442SIGNOR:21215781PhosphoSite:8930358PhosphoSite:28814543PhosphoSite:16095576ProtMapper:28807816PhosphoSite:11034902ProtMapper:21215781PhosphoSite:27641626PhosphoSite:18258852PhosphoSite:32437347ProtMapper:28775333HINT:17906291PhosphoSite:18922798PhosphoSite:33730588PhosphoSite:14761950PhosphoSite:30556160ProtMapper:16242644ProtMapper:24021800PhosphoSite:29950669HINT:11311121PhosphoSite:12226093ProtMapper:21843906ProtMapper:32029743PhosphoSite:16478768ProtMapper:21573099CA1:11311121PhosphoSite:21327254BioGRID:11311121ProtMapper:17906291ProtMapper:27483355
GSK3AP49840TAUP10636YesNoYesHPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAHPRDCui2007CA1WangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEABioGRIDHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper:18627032ProtMapper:17045592HINT:17045592CA1:8799840BioGRID:7931292HINT:16446437ProtMapper:33339170SIGNOR:9771888HINT:7931292ProtMapper:7706316CA1:8228990SIGNOR:7566348CA1:9689133KEA:7706316iPTMnet:7706316KEA:7931292ProtMapper:7931292HPRD:7931292SIGNOR:7706316ProtMapper:9771888HPRD:7706316CA1:11007782
COMPLEX:Q00535_Q15078TAUP10636YesNoYesSIGNORSIGNOR:21215781SIGNOR:12226093SIGNOR:12387894
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Protein Complex Composition

8 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
14-3-3q-SGK1-tau complexMAPTSGK1YWHAQO00141P10636P273480:0:0CORUMCORUM:624215650334
tubulin complexBICD1MAPTTPT1P10636P13693Q96G011:1:1CompleatCompleat:HC15151623798642405
AATFBAG3HSPA1BHSPA8MAPTO95817P0DMV9P10636P11142Q9NY611:2:1:1:1NetworkBlastCompleatCompleat:HC8266
MAPTP106362PDBPDB:8q2kPDB:7qkmPDB:7qk5PDB:9r2hPDB:8orgPDB:8q7mPDB:8oi0PDB:7qkwPDB:7mkgPDB:6vh7PDB:4e0nPDB:8otjPDB:5ziaPDB:6nwqPDB:8g58PDB:6h06PDB:7qjzPDB:8zwlPDB:8caqPDB:9czlPDB:7qklPDB:7ypgPDB:7upePDB:5mp1PDB:7p6dPDB:8q8cPDB:8q8sPDB:7qkuPDB:7p6bPDB:6vhaPDB:7qkyPDB:9b3aPDB:8q97PDB:7qk6PDB:8q8yPDB:7p6ePDB:9bxoPDB:7p68PDB:7qkvPDB:7p67PDB:8bgvPDB:8q8uPDB:8q9iPDB:8otiPDB:6qjpPDB:4glrPDB:6n4pPDB:8wcpPDB:9ermPDB:9eohPDB:8q9bPDB:8q9hPDB:7p6cPDB:8ttnPDB:7qkjPDB:8v1nPDB:9eo9PDB:7qjyPDB:8q9dPDB:8orePDB:9g13PDB:7qkxPDB:8q8mPDB:8q7pPDB:8q9cPDB:8ohpPDB:7nrtPDB:8q9oPDB:8q9gPDB:9b4oPDB:8q9mPDB:8oh2PDB:6qjmPDB:8orfPDB:9h5jPDB:8g54PDB:5o3lPDB:8ttlPDB:8q8xPDB:8ot6PDB:9bblPDB:8q8lPDB:9cgxPDB:7ql4PDB:8qjjPDB:8q2jPDB:7qjvPDB:6tjoPDB:8q7lPDB:7ql3PDB:6nwpPDB:5o3tPDB:7qkgPDB:7qkkPDB:8q8wPDB:8ohiPDB:8q9fPDB:8q88PDB:8q8fPDB:7ql0PDB:8q92PDB:6xliPDB:9r2fPDB:8r3tPDB:7mkfPDB:8ot9PDB:7ql2PDB:8fnzPDB:7nrvPDB:6qjqPDB:7r5hPDB:8q7tPDB:9ernPDB:9b4lPDB:6hrfPDB:7qk2PDB:9b4mPDB:9eogPDB:8qcrPDB:7kqkPDB:6vhlPDB:7nrsPDB:8q2lPDB:8q27PDB:9dmePDB:7qkzPDB:9gg6PDB:9cgzPDB:7u0zPDB:8caxPDB:6tjxPDB:8ppoPDB:8bynPDB:9bxiPDB:8q9aPDB:8bgsPDB:8qcpPDB:8zx6PDB:7p66PDB:7qjwPDB:8q8vPDB:4e0oPDB:2on9PDB:8q9jPDB:8q8ePDB:5o3oPDB:7upgPDB:7qk3PDB:6vi3PDB:8q8zPDB:9gg0PDB:8q8rPDB:8zwmPDB:7qjxPDB:7upfPDB:8g55PDB:9gg1PDB:6hrePDB:8q99PDB:7mkhPDB:8fugPDB:8otgPDB:5mp5PDB:7nrxPDB:7ymnPDB:5dmgPDB:8q7fPDB:8q8dPDB:9b4nPDB:7eycPDB:8otcPDB:9bxqPDB:9h5gPDB:7qkfPDB:7qk1PDB:7r4tPDB:8q98PDB:9fh6PDB:8q9ePDB:8othPDB:8sehPDB:8seiPDB:9eroPDB:9hbbPDB:9cziPDB:6gx5PDB:9bxrPDB:9b3cPDB:6odgPDB:7qkiPDB:6dcaPDB:7p65PDB:7p6aPDB:9bbmPDB:6dc9PDB:4e0mPDB:8q9lPDB:6qjhPDB:7nrqPDB:8uq7PDB:6bb4PDB:8q9kPDB:7sp1PDB:7qkhPDB:7ql1
HSPA8MAPTMARK1MARK4PKMSTK11P10636P11142P14618Q15831Q96L34Q9P0L21:1:1:1:1:1NetworkBlastCompleatCompleat:HC8278
MAPTSFNP10636P319472:2PDBPDB:6fawPDB:9fvhPDB:6fi4PDB:5btvPDB:6fi5PDB:4y5iPDB:6fbyPDB:4y3bPDB:9fviPDB:4fl5PDB:9fs4PDB:9fvpPDB:9fvnPDB:4y32PDB:6fauPDB:9fvgPDB:6favPDB:5hf3PDB:6fbw
MAPTYWHAZP10636P631042:4PDBPDB:8qdv
MAPTPIN1P10636Q135261:1PDBPDB:1i8h

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryWestern blottingELISA3387318682470086432231660
Sequence, Structure & Domains

Sequences

Length
758
Mass
78,928
Sequence
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Alternative Products
Event=Alternative splicing; Named isoforms=9; Comment=Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat.; Name=PNS-tau; IsoId=P10636-1; Sequence=Displayed; Name=Fetal-tau; Synonyms=0N3R; IsoId=P10636-2; Sequence=VSP_003176, VSP_003177, VSP_003179, VSP_003180, VSP_003181; Name=Tau-A; IsoId=P10636-3; Sequence=VSP_003175, VSP_003176, VSP_003177, VSP_003178, VSP_003179, VSP_003180, VSP_003181; Name=Tau-B; Synonyms=1N3R; IsoId=P10636-4; Sequence=VSP_003177, VSP_003179, VSP_003180, VSP_003181; Name=Tau-C; Synonyms=Tau-3, 2N3R; IsoId=P10636-5; Sequence=VSP_003179, VSP_003180, VSP_003181; Name=Tau-D; Synonyms=0N4R; IsoId=P10636-6; Sequence=VSP_003176, VSP_003177, VSP_003179, VSP_003180; Name=Tau-E; Synonyms=1N4R; IsoId=P10636-7; Sequence=VSP_003177, VSP_003179, VSP_003180; Name=Tau-F; Synonyms=Tau-4, 2N4R; IsoId=P10636-8; Sequence=VSP_003179, VSP_003180; Name=Tau-G; IsoId=P10636-9; Sequence=VSP_026780
Alternative Sequence
1..44; MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLK -> MLRALQQRKR (in isoform Tau-A); 45..73; Missing (in isoform Tau-A, isoform Tau-D and isoform Fetal-tau); 74..102; Missing (in isoform Tau-A, isoform Tau-B, isoform Tau-D, isoform Tau-E and isoform Fetal-tau); 103..104; Missing (in isoform Tau-A); 125..375; Missing (in isoform Tau-A, isoform Tau-B, isoform Tau-C, isoform Tau-D, isoform Tau-E, isoform Tau-F and isoform Fetal-tau); 395..460; Missing (in isoform Tau-A, isoform Tau-B, isoform Tau-C, isoform Tau-D, isoform Tau-E, isoform Tau-F and isoform Fetal-tau); 502; S -> SATKQVQRRPPPAGPRSER (in isoform Tau-G); 592..622; Missing (in isoform Tau-A, isoform Tau-B, isoform Tau-C and isoform Fetal-tau)

3D Structural Models

Turn
63..65; 579..582
Helix
60..62
Beta Strand
7..9; 587..590; 592..610; 613..615; 618..620; 624..626; 629..631; 634..643; 645..648; 654..660; 662..665; 667..671; 673..679; 682..684; 685..695; 698..703; 709..712; 716..720; 723..732; 734..736; 741..751; 753..755
3D Structure
Electron microscopy (193); NMR spectroscopy (8); X-ray crystallography (45)

Domain & Motif Annotations

Compositional Bias
1..26; Basic and acidic residues; 61..71; Polar residues; 179..189; Basic and acidic residues; 207..216; Basic and acidic residues; 217..228; Acidic residues; 314..323; Basic and acidic residues; 324..340; Low complexity; 344..356; Basic and acidic residues; 381..393; Basic and acidic residues; 442..453; Low complexity; 455..466; Basic and acidic residues; 491..503; Pro residues; 504..531; Low complexity; 718..733; Polar residues
Repeat
561..591; Tau/MAP 1; 592..622; Tau/MAP 2; 623..653; Tau/MAP 3; 654..685; Tau/MAP 4
Domain (CC)
The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
Region
1..573; Disordered; 561..685; Microtubule-binding domain; 715..734; Disordered
Clinical Relevance
Disease Involvement
Alzheimer diseaseDisease variantFDA approved drug targetsNeurodegenerationParkinsonism
Biomarker
Phase 3; Investigative; Phase 2
Drug Targets
FDA approved drug targetsPatented-recorded targetLiterature-reported targetClinical trial targetSuccessful target
Drugs
2,3-DIHYDROXY-4-METHOXY-4'-ETHOXYBENZOPHENONERESERPINECHEMBL:CHEMBL579837CHEMBL:CHEMBL328710RHAMNETINISOBOLDINEDEHYDROVARIABILINCHEMBL:CHEMBL1466186DIHYDROERGOTAMINE MESYLATECATECHINITRACONAZOLEHAEMATOXYLINSANGUINARINE SULFATEHELIOMYCINEMBELINALLOXANCHEMBL:CHEMBL601367CHEMBL:CHEMBL13973081,4-DIMETHOXYANTHRAQUINONENULLCHEMBL:CHEMBL606166CHEMBL:CHEMBL590186CHEMBL:CHEMBL428789CHEMBL:CHEMBL310934HELENALINBISANHYDRORUTILANTINONECHEMBL:CHEMBL600694CHLORANILROSMARINIC ACIDCHEMBL:CHEMBL1534034CHEMBL:CHEMBL582286CYSTAMINE HYDROCHLORIDECHEMBL:CHEMBL581044CHEMBL:CHEMBL533965ARISTOLOCHIC ACIDAPIGENIN2,3,4-TRIHYDROXY-4'-ETHOXYBENZOPHENONEKOPARINU-0126CEAROINPOSDINEMABTYRPHOSTIN 51BAICALEINHEXACHLOROPHENECHEMBL:CHEMBL533293ACID BLUE 129GENTIAN VIOLET CATIONERGOCRISTINEPROTOAPIGENONENIFUROXAZIDESEMORINEMABTILAVONEMABDOCEBENONECHEMBL:CHEMBL2095095CHEMBL:CHEMBL5782572,6-DIMETHOXYQUINONEDANTROLENEPTEROSTILBENEZAGOTENEMABROTTLERIN12A-HYDROXY-5-DEOXYDEHYDROMUNDUSERONESULFURETINMORININDIRUBIN-3'-MONOXIMEAG 9METHYL 7-DESHYDROXYPYROGALLIN-4-CARBOXYLATEDIHYDROERGOCRISTINEANGUSTIBALINCHEMBL:CHEMBL609606FELODIPINEGOSURANEMABOXYPHENBUTAZONETANSHINONE IIACYSTAMINE DIHYDROCHLORIDECRYPTOTANSHINONECHELERYTHRINE CHLORIDEBISSALICYL FUMARATECHEMBL:CHEMBL600738CHEMBL:CHEMBL166486MYRICETINGW441756XCHEMBL:CHEMBL313737DEXKETOPROFENIRIGINOL HEXAACEATATEGALLIC ACIDCHEMBL:CHEMBL1569494CHEMBL:CHEMBL601353LAVENDUSTIN ACHEMBL:CHEMBL1335833CHEMBL:CHEMBL175266NIGULDIPINETYRPHOSTIN A9CHEMBL:CHEMBL429095CIS-RESVERATROLEMODIC ACIDCHEMBL:CHEMBL1426508TETROQUINONECHEMBL:CHEMBL580071CHEMBL:CHEMBL587620CHEMBL:CHEMBL586061NICLOSAMIDEAPOMORPHINE2-MERCAPTOETHANESULFONIC ACIDMANGOSTINAMENTOFLAVONETOLONIUM CHLORIDEGRINIMIBINESTICTIC ACIDGW5074FENRETINIDE5-HYDROXYTRYPTOPHANCHEMBL:CHEMBL584442CHEMBL:CHEMBL1567571TYRPHOSTIN 23PHOSMETALTENUSINBITHIONOLGOSSYPETINATHRAQUINONES ACHEMBL:CHEMBL581574CHEMBL:CHEMBL314639CHEMBL:CHEMBL579105CHEMBL:CHEMBL274921CHEMBL:CHEMBL1390716CHEMBL:CHEMBL578890CHEMBL:CHEMBL67535CHLOROTHALONILSLAZINIC ACIDERBSTATINBERBERINE CHLORIDENSC-663284NBQXSHIKONINDIHYDROXANTHOHUMOLCHEMBL:CHEMBL601618PROPYLENE GLYCOL MONOSTEARATE4-PHENYLENEDIAMINEDEPHOSTATINPHENAZOPYRIDINE HYDROCHLORIDEDALBERGIONE, 4-METHOXY-4'-HYDROXY-CHEMBL:CHEMBL584458CHEMBL:CHEMBL1503190OSAJINHOMIDIUM BROMIDECHEMBL:CHEMBL536375CISPLATINCHEMBL:CHEMBL1543865CHEMBL:CHEMBL528807DOXORUBICIN HYDROCHLORIDETRANSPLATINRABEPRAZOLECALCIMYCINNORDEFRINQUINALIZARINCARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONECHEMBL:CHEMBL1989853DAUNORUBICIN HYDROCHLORIDECHEMBL:CHEMBL1451216RHEINCHEMBL:CHEMBL1510164IRIGENOLCHEMBL:CHEMBL505670GUTHIONSB-4081242-BENZOYL-5-METHOXYBENZOQUINONECHEMBL:CHEMBL591628CHEMBL:CHEMBL1372046NIFEDIPINECHEMBL:CHEMBL578512CHEMBL:CHEMBL592124NOREPINEPHRINESARCOLYSINPARAROSANILINECHEMBL:CHEMBL2181041CHEMBL:CHEMBL19954SR26403,4-DIDESMETHYL-5-DESHYDROXY-3'-ETHOXYSCLEROINLUTEOLINCHEMBL:CHEMBL59150CHEMBL:CHEMBL2002487CHEMBL:CHEMBL244707CHEMBL:CHEMBL1306524BROMOENOL LACTONECARBOPLATINEPIGALLOCATECHIN-3-GALLATECHEMBL:CHEMBL591137WORTMANNINDITHIAZANINE IODIDEELLIPTECINECHEMBL:CHEMBL582473CHEMBL:CHEMBL600734PURPUROGALLINSB-415286CHEMBL:CHEMBL122701CHEMBL:CHEMBL1546228CHEMBL:CHEMBL601385CHEMBL:CHEMBL211670CHEMBL:CHEMBL2094422CURCUMINCHEMBL:CHEMBL6073095-BENZYLOXYTRYPTAMINEDECYNIUM 22CHEMBL:CHEMBL1367933CHEMBL:CHEMBL1079460CHEMBL:CHEMBL227959CHEMBL:CHEMBL578741(-)-N-PORPHYNORAPOMORPHINECAPSAZEPINEGOSSYPOLCHEMBL:CHEMBL585654CHEMBL:CHEMBL457504BENSERAZIDE HYDROCHLORIDEHYPERICINCOUMESTROLCHEMBL:CHEMBL1519374INDIGOXANTHOANGELOLCHEMBL:CHEMBL1402376CHEMBL:CHEMBL586000BCR-ABL INHIBITOR GNF-2CHEMBL:CHEMBL458094AHPNCHEMBL:CHEMBL527584CHEMBL:CHEMBL2094456CHEMBL:CHEMBL1984884BILIRUBINPYRANTEL PAMOATECHEMBL:CHEMBL606167ACITRETINOMEPRAZOLECHEMBL:CHEMBL1224755EPINEPHRINE BITARTRATECARNOSIC ACIDCHEMBL:CHEMBL17201EPALRESTATSULFASALAZINECHEMBL:CHEMBL580421CGP53353CHEMBL:CHEMBL601192LANSOPRAZOLETRICLABENDAZOLEAPOMORPHINE HYDROCHLORIDE HEMIHYDRATECHEMBL:CHEMBL585656TYRPHOSTIN 47ZK-93423METHYLDOPA (RACEMIC)MECYSTEINE HYDROCHLORIDECHEMBL:CHEMBL242171CHEMBL:CHEMBL343002CHEMBL:CHEMBL126804GEFITINIBCHEMBL:CHEMBL580183CHEMBL:CHEMBL538542CHEMBL:CHEMBL586031CHEMBL:CHEMBL2181039DIAMIDEQUERCETINCHEMBL:CHEMBL600747FLUPIRTINE MALEATEDIHYDROGAMBOGIC ACIDCHEMBL:CHEMBL528181CHEMBL:CHEMBL602969CHEMBL:CHEMBL1379900AGROCLAVINE3-METHYLCHOLANTHRENECHEMBL:CHEMBL538104CHEMBL:CHEMBL605077CHEMBL:CHEMBL601952CHEMBL:CHEMBL578294THIOLUTINIDARUBICINETHOPROPAZINE HYDROCHLORIDEBEPRANEMABCHOLECALCIFEROLOXOPURPUREINENITAZOXANIDECHEMBL:CHEMBL601605CHEMBL:CHEMBL603952CHEMBL:CHEMBL590691S(+)-APOMORPHINEAURINTRICARBOXYLIC ACIDLAPACHOL4,4'-DIMETHOXYDALBERGIONERACEPINEPHRINECHEMBL:CHEMBL548017&ALPHA-ERGOCRYPTINEHYDROXYZINE PAMOATECHEMBL:CHEMBL546576PROTOPORPHYRINOBTUSAQUINONE3,4-DIMETHOXYDALBERGIONESEMAXANIBPICEATANNOLCHEMBL:CHEMBL85194DAUNORUBICIN LIPOSOMALDAMNACANTHALFUMARPROTOCETRARIC ACIDMAHANIMBINESAPPANONE A DIMETHYL ETHERCHEMBL:CHEMBL1498652PURPURINNPPBCHEMBL:CHEMBL527620ETHACRIDINE LACTATEGETIACAULEINIODOPHTHALEINPHENSERINEPIPLARTINEFISETINCHEMBL:CHEMBL339587RO31-8220CHEMBL:CHEMBL1465049CHEMBL:CHEMBL462861TYRPHOSTIN 25CARBIDOPA ANHYDROUSHARMALOLCHEMBL:CHEMBL582715CHEMBL:CHEMBL1939691CHEMBL:CHEMBL139935LINOLENIC ACIDCHEMBL:CHEMBL578504METHYSERGIDE MALEATEELLAGIC ACIDCHEMBL:CHEMBL399530CHEMBL:CHEMBL515252TRIBROMSALANCHEMBL:CHEMBL1334191EPINEPHRINEEMODINPOMIFERIN9,10-PHENANTHRENEQUINONECHEMBL:CHEMBL99408PANTOPRAZOLE SODIUMSAPPANONE A TRIMETHYL ETHERCHEMBL:CHEMBL1574420CHEMBL:CHEMBL1588679CHEMBL:CHEMBL585591CHEMBL:CHEMBL586078CHEMBL:CHEMBL595227Z-PRO-PROLINALTYRPHOSTIN B48HEMATOXYLINDICHLOROPHENAROMATICINOXOGLAUCINECEFACLOR ANHYDROUSCHEMBL:CHEMBL1601846CHEMBL:CHEMBL523200CHEMBL:CHEMBL297304SU9516PLUMBAGINDIHYDROERGOCRISTINE MESYLATEGW282974XCHEMBL:CHEMBL68534RALOXIFENE HYDROCHLORIDEISOGINKGETINZAPACHEMBL:CHEMBL1257092CHEMBL:CHEMBL77387CARUBICINHOMIDIUMMACLURAXANTHONEMETHYLENE BLUE ANHYDROUSPD-980591,10-PHENANTHROLINELAPACHONECHEMBL:CHEMBL2181040SB 204741PHENOTHIAZINESTAUROSPORINE AGLYCONPBT-1033PD-169316ARACHIDONIC ACIDCHEMBL:CHEMBL1320453CHEMBL:CHEMBL2343383-METHOXYCATECHOLISOVELLERALTANSHINONE ICHEMBL:CHEMBL531322TRIMETREXATEOXIDOPAMINE HYDROCHLORIDEGARCINONE EARUNDINEVITAMIN K3ISOEUGENITOLVU0001171INAMRINONECHEMBL:CHEMBL578905CHEMBL:CHEMBL1609016CHEMBL:CHEMBL601110CHEMBL:CHEMBL312487SANGUINARIUM CHLORIDECHEMBL:CHEMBL525103CHEMBL:CHEMBL252417MASOPROCOLP-AMINOHIPPURATEMETHYLTHIONINIUM CHLORIDEDERRUBONETRICETINDOCONEXENTCYSTEAMINE HYDROCHLORIDECHEMBL:CHEMBL1412489AM404RESVERATROLL 755507CHELERYTHRINEOXYTETRACYCLINE ANHYDROUS1,2-NAPHTHOQUINONEDAPHMITOXANTRONE HYDROCHLORIDEAMSACRINE HYDROCHLORIDECHEMBL:CHEMBL2181046CHEMBL:CHEMBL196814GF109203XCHEMBL:CHEMBL5970353,4-DICHLOROISOCOUMARINISOLIQUIRITIGENINCHEMBL:CHEMBL1814509CONGO REDCHEMBL:CHEMBL222556BITHIONOLATE SODIUMCHEMBL:CHEMBL546597PITTSBURGH COMPOUND BCHEMBL:CHEMBL146710STREPTONIGRINPATULINNORSTICTIC ACIDCAFFEIC ACID PHENETHYL ESTERDIMETHYL GAMBOGATECHEMBL:CHEMBL184074KAEMPHEROLCHEMBL:CHEMBL493863RATANIAPHENOL IISANGUINARIUMCHEMBL:CHEMBL601140JUGLONEPYRROLIDINE DITHIOCARBAMIC ACID, AMMONIUM SALT4-METHOXYDALBERGIONECHEMBL:CHEMBL580155N-OLEOYLDOPAMINE
Interaction Protein
ENSG00000010810ENSG00000082701ENSG00000103266ENSG00000109971ENSG00000134308ENSG00000142192ENSG00000142208ENSG00000146648ENSG00000164924ENSG00000185624ENSG00000275700
Interaction Count
11
Interaction Dataset
intact_biogrid