Protein detail
TAU
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Protein symbol TAU | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count | Protein classification Candidate cardiovascular disease genesDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins |
Basic Information
Protein Names
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Protein Class
Candidate cardiovascular disease genesDisease related genesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Candidate cardiovascular disease genes
- Predicted secreted proteins
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
DDPACFLJ31424FTDP-17MAPTLMGC138549MSTDMTBT1MTBT2PPNDPPP1R103tautau-40
Gene Description
Microtubule associated protein tau
Chromosome
17
Position
45894527-46028334
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificEsophageal apical cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Candidate cardiovascular disease genes
- Predicted secreted proteins
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005576 extracellular region
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005739 mitochondrion
- GO:0005829 cytosol
- GO:0005874 microtubule
- GO:0005886 plasma membrane
- GO:0015630 microtubule cytoskeleton
- GO:0016020 membrane
- GO:0016607 nuclear speck
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0030426 growth cone
- GO:0030673 axolemma
- GO:0034399 nuclear periphery
- GO:0036464 cytoplasmic ribonucleoprotein granule
- GO:0036477 somatodendritic compartment
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0043197 dendritic spine
- GO:0044297 cell body
- GO:0044304 main axon
- GO:0045121 membrane raft
- GO:0045298 tubulin complex
- GO:0097386 glial cell projection
- GO:0097418 neurofibrillary tangle
- GO:1904115 axon cytoplasm
Molecular Function
- GO:0003677 DNA binding
- GO:0003680 minor groove of adenine-thymine-rich DNA binding
- GO:0003690 double-stranded DNA binding
- GO:0003697 single-stranded DNA binding
- GO:0003723 RNA binding
- GO:0003779 actin binding
- GO:0005515 protein binding
- GO:0008017 microtubule binding
- GO:0017124 SH3 domain binding
- GO:0019899 enzyme binding
- GO:0019901 protein kinase binding
- GO:0030674 protein-macromolecule adaptor activity
- GO:0034185 apolipoprotein binding
- GO:0034452 dynactin binding
- GO:0035091 phosphatidylinositol binding
- GO:0042802 identical protein binding
- GO:0043565 sequence-specific DNA binding
- GO:0051087 protein-folding chaperone binding
- GO:0051721 protein phosphatase 2A binding
- GO:0051879 Hsp90 protein binding
- GO:0071813 lipoprotein particle binding
- GO:0099077 histone-dependent DNA binding
- GO:0099609 microtubule lateral binding
- GO:1902936 phosphatidylinositol bisphosphate binding
Biological Process
KEGG
Reactome
- R-hsa-9619483 activation of ampk downstream of nmdars
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-1169410 antimicrobial mechanism of ifn stimulated genes
- R-hsa-109581 apoptosis
- R-hsa-111465 apoptotic cleavage of cellular proteins
- R-hsa-75153 apoptotic execution phase
- R-hsa-264870 caspase mediated cleavage of cytoskeletal proteins
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-913531 interferon signaling
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-9833482 pkr mediated signaling
- R-hsa-5357801 programmed cell death
- R-hsa-112315 transmission across chemical synapses
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1,054 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MAPT | PRKACA | P17612 | S | 324 | phosphorylation | PhosphoSite | |
| MAPT | GSK3B | P49841 | S | 530 | phosphorylation | MIMPHPRD_MIMPPhosphoSite_MIMP | |
| MAPT | GSK3B | P49841 | S | 533 | phosphorylation | MIMPHPRD_MIMPPhosphoSite_MIMP | |
| MAPT | PRKACA | P17612 | S | 316 | phosphorylation | PhosphoSite | |
| MAPT | PRKACA | P17612 | S | 293 | phosphorylation | PhosphoSite | |
| MAPT | GSK3B | P49841 | S | 534 | phosphorylation | MIMPHPRD_MIMPPhosphoSite_MIMP | |
| MAPT | GSK3B | P49841 | S | 554 | phosphorylation | PhosphoNetworks | |
| MAPT | GSK3B | P49841 | S | 637 | phosphorylation | PhosphoNetworks | |
| MAPT | GSK3B | P49841 | S | 726 | phosphorylation | PhosphoNetworks | |
| MAPT | GSK3B | P49841 | T | 548 | phosphorylation | PhosphoNetworksSparser_ProtMapperSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapper | KEA:9353289ProtMapper:22690349HPRD:9832145KEA:7566346HPRD:17287340SIGNOR:12387894KEA:9771888HPRD:9735171KEA:9735171SIGNOR:21215781ProtMapper:29725295ProtMapper:22278060KEA:9199504phosphoELM:9565682ProtMapper:21215781HPRD:7566346HPRD:19651622HPRD:20068231ProtMapper:12387894KEA:12387894KEA:9832145HPRD:12387894ProtMapper:14690523HPRD:9565682HPRD:9199504ProtMapper:17047304HPRD:9771888HPRD:9353289KEA:9565682 |
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Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
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Regulatory Interaction Network
50 records.
Protein Complex Composition
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| 14-3-3q-SGK1-tau complex | MAPTSGK1YWHAQ | O00141P10636P27348 | 0:0:0 | CORUM | CORUM:6242 | 15650334 |
| tubulin complex | BICD1MAPTTPT1 | P10636P13693Q96G01 | 1:1:1 | Compleat | Compleat:HC15 | 151623798642405 |
| AATFBAG3HSPA1BHSPA8MAPT | O95817P0DMV9P10636P11142Q9NY61 | 1:2:1:1:1 | NetworkBlastCompleat | Compleat:HC8266 | ||
| MAPT | P10636 | 2 | PDB | PDB:8q2kPDB:7qkmPDB:7qk5PDB:9r2hPDB:8orgPDB:8q7mPDB:8oi0PDB:7qkwPDB:7mkgPDB:6vh7PDB:4e0nPDB:8otjPDB:5ziaPDB:6nwqPDB:8g58PDB:6h06PDB:7qjzPDB:8zwlPDB:8caqPDB:9czlPDB:7qklPDB:7ypgPDB:7upePDB:5mp1PDB:7p6dPDB:8q8cPDB:8q8sPDB:7qkuPDB:7p6bPDB:6vhaPDB:7qkyPDB:9b3aPDB:8q97PDB:7qk6PDB:8q8yPDB:7p6ePDB:9bxoPDB:7p68PDB:7qkvPDB:7p67PDB:8bgvPDB:8q8uPDB:8q9iPDB:8otiPDB:6qjpPDB:4glrPDB:6n4pPDB:8wcpPDB:9ermPDB:9eohPDB:8q9bPDB:8q9hPDB:7p6cPDB:8ttnPDB:7qkjPDB:8v1nPDB:9eo9PDB:7qjyPDB:8q9dPDB:8orePDB:9g13PDB:7qkxPDB:8q8mPDB:8q7pPDB:8q9cPDB:8ohpPDB:7nrtPDB:8q9oPDB:8q9gPDB:9b4oPDB:8q9mPDB:8oh2PDB:6qjmPDB:8orfPDB:9h5jPDB:8g54PDB:5o3lPDB:8ttlPDB:8q8xPDB:8ot6PDB:9bblPDB:8q8lPDB:9cgxPDB:7ql4PDB:8qjjPDB:8q2jPDB:7qjvPDB:6tjoPDB:8q7lPDB:7ql3PDB:6nwpPDB:5o3tPDB:7qkgPDB:7qkkPDB:8q8wPDB:8ohiPDB:8q9fPDB:8q88PDB:8q8fPDB:7ql0PDB:8q92PDB:6xliPDB:9r2fPDB:8r3tPDB:7mkfPDB:8ot9PDB:7ql2PDB:8fnzPDB:7nrvPDB:6qjqPDB:7r5hPDB:8q7tPDB:9ernPDB:9b4lPDB:6hrfPDB:7qk2PDB:9b4mPDB:9eogPDB:8qcrPDB:7kqkPDB:6vhlPDB:7nrsPDB:8q2lPDB:8q27PDB:9dmePDB:7qkzPDB:9gg6PDB:9cgzPDB:7u0zPDB:8caxPDB:6tjxPDB:8ppoPDB:8bynPDB:9bxiPDB:8q9aPDB:8bgsPDB:8qcpPDB:8zx6PDB:7p66PDB:7qjwPDB:8q8vPDB:4e0oPDB:2on9PDB:8q9jPDB:8q8ePDB:5o3oPDB:7upgPDB:7qk3PDB:6vi3PDB:8q8zPDB:9gg0PDB:8q8rPDB:8zwmPDB:7qjxPDB:7upfPDB:8g55PDB:9gg1PDB:6hrePDB:8q99PDB:7mkhPDB:8fugPDB:8otgPDB:5mp5PDB:7nrxPDB:7ymnPDB:5dmgPDB:8q7fPDB:8q8dPDB:9b4nPDB:7eycPDB:8otcPDB:9bxqPDB:9h5gPDB:7qkfPDB:7qk1PDB:7r4tPDB:8q98PDB:9fh6PDB:8q9ePDB:8othPDB:8sehPDB:8seiPDB:9eroPDB:9hbbPDB:9cziPDB:6gx5PDB:9bxrPDB:9b3cPDB:6odgPDB:7qkiPDB:6dcaPDB:7p65PDB:7p6aPDB:9bbmPDB:6dc9PDB:4e0mPDB:8q9lPDB:6qjhPDB:7nrqPDB:8uq7PDB:6bb4PDB:8q9kPDB:7sp1PDB:7qkhPDB:7ql1 | ||
| HSPA8MAPTMARK1MARK4PKMSTK11 | P10636P11142P14618Q15831Q96L34Q9P0L2 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8278 | ||
| MAPTSFN | P10636P31947 | 2:2 | PDB | PDB:6fawPDB:9fvhPDB:6fi4PDB:5btvPDB:6fi5PDB:4y5iPDB:6fbyPDB:4y3bPDB:9fviPDB:4fl5PDB:9fs4PDB:9fvpPDB:9fvnPDB:4y32PDB:6fauPDB:9fvgPDB:6favPDB:5hf3PDB:6fbw | ||
| MAPTYWHAZ | P10636P63104 | 2:4 | PDB | PDB:8qdv | ||
| MAPTPIN1 | P10636Q13526 | 1:1 | PDB | PDB:1i8h |
Sequence, Structure & Domains
Sequences
Length
758
Mass
78,928
Sequence
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Alternative Products
Event=Alternative splicing; Named isoforms=9; Comment=Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat.; Name=PNS-tau; IsoId=P10636-1; Sequence=Displayed; Name=Fetal-tau; Synonyms=0N3R; IsoId=P10636-2; Sequence=VSP_003176, VSP_003177, VSP_003179, VSP_003180, VSP_003181; Name=Tau-A; IsoId=P10636-3; Sequence=VSP_003175, VSP_003176, VSP_003177, VSP_003178, VSP_003179, VSP_003180, VSP_003181; Name=Tau-B; Synonyms=1N3R; IsoId=P10636-4; Sequence=VSP_003177, VSP_003179, VSP_003180, VSP_003181; Name=Tau-C; Synonyms=Tau-3, 2N3R; IsoId=P10636-5; Sequence=VSP_003179, VSP_003180, VSP_003181; Name=Tau-D; Synonyms=0N4R; IsoId=P10636-6; Sequence=VSP_003176, VSP_003177, VSP_003179, VSP_003180; Name=Tau-E; Synonyms=1N4R; IsoId=P10636-7; Sequence=VSP_003177, VSP_003179, VSP_003180; Name=Tau-F; Synonyms=Tau-4, 2N4R; IsoId=P10636-8; Sequence=VSP_003179, VSP_003180; Name=Tau-G; IsoId=P10636-9; Sequence=VSP_026780
Alternative Sequence
1..44; MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLK -> MLRALQQRKR (in isoform Tau-A); 45..73; Missing (in isoform Tau-A, isoform Tau-D and isoform Fetal-tau); 74..102; Missing (in isoform Tau-A, isoform Tau-B, isoform Tau-D, isoform Tau-E and isoform Fetal-tau); 103..104; Missing (in isoform Tau-A); 125..375; Missing (in isoform Tau-A, isoform Tau-B, isoform Tau-C, isoform Tau-D, isoform Tau-E, isoform Tau-F and isoform Fetal-tau); 395..460; Missing (in isoform Tau-A, isoform Tau-B, isoform Tau-C, isoform Tau-D, isoform Tau-E, isoform Tau-F and isoform Fetal-tau); 502; S -> SATKQVQRRPPPAGPRSER (in isoform Tau-G); 592..622; Missing (in isoform Tau-A, isoform Tau-B, isoform Tau-C and isoform Fetal-tau)
3D Structural Models
Turn
63..65; 579..582
Helix
60..62
Beta Strand
7..9; 587..590; 592..610; 613..615; 618..620; 624..626; 629..631; 634..643; 645..648; 654..660; 662..665; 667..671; 673..679; 682..684; 685..695; 698..703; 709..712; 716..720; 723..732; 734..736; 741..751; 753..755
3D Structure
Electron microscopy (193); NMR spectroscopy (8); X-ray crystallography (45)
Domain & Motif Annotations
Compositional Bias
1..26; Basic and acidic residues; 61..71; Polar residues; 179..189; Basic and acidic residues; 207..216; Basic and acidic residues; 217..228; Acidic residues; 314..323; Basic and acidic residues; 324..340; Low complexity; 344..356; Basic and acidic residues; 381..393; Basic and acidic residues; 442..453; Low complexity; 455..466; Basic and acidic residues; 491..503; Pro residues; 504..531; Low complexity; 718..733; Polar residues
Repeat
561..591; Tau/MAP 1; 592..622; Tau/MAP 2; 623..653; Tau/MAP 3; 654..685; Tau/MAP 4
Domain (CC)
The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
Region
1..573; Disordered; 561..685; Microtubule-binding domain; 715..734; Disordered
Clinical Relevance
Disease Involvement
Alzheimer diseaseDisease variantFDA approved drug targetsNeurodegenerationParkinsonism
Related Diseases
Biomarker
Phase 3; Investigative; Phase 2
Drug Targets
FDA approved drug targetsPatented-recorded targetLiterature-reported targetClinical trial targetSuccessful target
Drugs
2,3-DIHYDROXY-4-METHOXY-4'-ETHOXYBENZOPHENONERESERPINECHEMBL:CHEMBL579837CHEMBL:CHEMBL328710RHAMNETINISOBOLDINEDEHYDROVARIABILINCHEMBL:CHEMBL1466186DIHYDROERGOTAMINE MESYLATECATECHINITRACONAZOLEHAEMATOXYLINSANGUINARINE SULFATEHELIOMYCINEMBELINALLOXANCHEMBL:CHEMBL601367CHEMBL:CHEMBL13973081,4-DIMETHOXYANTHRAQUINONENULLCHEMBL:CHEMBL606166CHEMBL:CHEMBL590186CHEMBL:CHEMBL428789CHEMBL:CHEMBL310934HELENALINBISANHYDRORUTILANTINONECHEMBL:CHEMBL600694CHLORANILROSMARINIC ACIDCHEMBL:CHEMBL1534034CHEMBL:CHEMBL582286CYSTAMINE HYDROCHLORIDECHEMBL:CHEMBL581044CHEMBL:CHEMBL533965ARISTOLOCHIC ACIDAPIGENIN2,3,4-TRIHYDROXY-4'-ETHOXYBENZOPHENONEKOPARINU-0126CEAROINPOSDINEMABTYRPHOSTIN 51BAICALEINHEXACHLOROPHENECHEMBL:CHEMBL533293ACID BLUE 129GENTIAN VIOLET CATIONERGOCRISTINEPROTOAPIGENONENIFUROXAZIDESEMORINEMABTILAVONEMABDOCEBENONECHEMBL:CHEMBL2095095CHEMBL:CHEMBL5782572,6-DIMETHOXYQUINONEDANTROLENEPTEROSTILBENEZAGOTENEMABROTTLERIN12A-HYDROXY-5-DEOXYDEHYDROMUNDUSERONESULFURETINMORININDIRUBIN-3'-MONOXIMEAG 9METHYL 7-DESHYDROXYPYROGALLIN-4-CARBOXYLATEDIHYDROERGOCRISTINEANGUSTIBALINCHEMBL:CHEMBL609606FELODIPINEGOSURANEMABOXYPHENBUTAZONETANSHINONE IIACYSTAMINE DIHYDROCHLORIDECRYPTOTANSHINONECHELERYTHRINE CHLORIDEBISSALICYL FUMARATECHEMBL:CHEMBL600738CHEMBL:CHEMBL166486MYRICETINGW441756XCHEMBL:CHEMBL313737DEXKETOPROFENIRIGINOL HEXAACEATATEGALLIC ACIDCHEMBL:CHEMBL1569494CHEMBL:CHEMBL601353LAVENDUSTIN ACHEMBL:CHEMBL1335833CHEMBL:CHEMBL175266NIGULDIPINETYRPHOSTIN A9CHEMBL:CHEMBL429095CIS-RESVERATROLEMODIC ACIDCHEMBL:CHEMBL1426508TETROQUINONECHEMBL:CHEMBL580071CHEMBL:CHEMBL587620CHEMBL:CHEMBL586061NICLOSAMIDEAPOMORPHINE2-MERCAPTOETHANESULFONIC ACIDMANGOSTINAMENTOFLAVONETOLONIUM CHLORIDEGRINIMIBINESTICTIC ACIDGW5074FENRETINIDE5-HYDROXYTRYPTOPHANCHEMBL:CHEMBL584442CHEMBL:CHEMBL1567571TYRPHOSTIN 23PHOSMETALTENUSINBITHIONOLGOSSYPETINATHRAQUINONES ACHEMBL:CHEMBL581574CHEMBL:CHEMBL314639CHEMBL:CHEMBL579105CHEMBL:CHEMBL274921CHEMBL:CHEMBL1390716CHEMBL:CHEMBL578890CHEMBL:CHEMBL67535CHLOROTHALONILSLAZINIC ACIDERBSTATINBERBERINE CHLORIDENSC-663284NBQXSHIKONINDIHYDROXANTHOHUMOLCHEMBL:CHEMBL601618PROPYLENE GLYCOL MONOSTEARATE4-PHENYLENEDIAMINEDEPHOSTATINPHENAZOPYRIDINE HYDROCHLORIDEDALBERGIONE, 4-METHOXY-4'-HYDROXY-CHEMBL:CHEMBL584458CHEMBL:CHEMBL1503190OSAJINHOMIDIUM BROMIDECHEMBL:CHEMBL536375CISPLATINCHEMBL:CHEMBL1543865CHEMBL:CHEMBL528807DOXORUBICIN HYDROCHLORIDETRANSPLATINRABEPRAZOLECALCIMYCINNORDEFRINQUINALIZARINCARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONECHEMBL:CHEMBL1989853DAUNORUBICIN HYDROCHLORIDECHEMBL:CHEMBL1451216RHEINCHEMBL:CHEMBL1510164IRIGENOLCHEMBL:CHEMBL505670GUTHIONSB-4081242-BENZOYL-5-METHOXYBENZOQUINONECHEMBL:CHEMBL591628CHEMBL:CHEMBL1372046NIFEDIPINECHEMBL:CHEMBL578512CHEMBL:CHEMBL592124NOREPINEPHRINESARCOLYSINPARAROSANILINECHEMBL:CHEMBL2181041CHEMBL:CHEMBL19954SR26403,4-DIDESMETHYL-5-DESHYDROXY-3'-ETHOXYSCLEROINLUTEOLINCHEMBL:CHEMBL59150CHEMBL:CHEMBL2002487CHEMBL:CHEMBL244707CHEMBL:CHEMBL1306524BROMOENOL LACTONECARBOPLATINEPIGALLOCATECHIN-3-GALLATECHEMBL:CHEMBL591137WORTMANNINDITHIAZANINE IODIDEELLIPTECINECHEMBL:CHEMBL582473CHEMBL:CHEMBL600734PURPUROGALLINSB-415286CHEMBL:CHEMBL122701CHEMBL:CHEMBL1546228CHEMBL:CHEMBL601385CHEMBL:CHEMBL211670CHEMBL:CHEMBL2094422CURCUMINCHEMBL:CHEMBL6073095-BENZYLOXYTRYPTAMINEDECYNIUM 22CHEMBL:CHEMBL1367933CHEMBL:CHEMBL1079460CHEMBL:CHEMBL227959CHEMBL:CHEMBL578741(-)-N-PORPHYNORAPOMORPHINECAPSAZEPINEGOSSYPOLCHEMBL:CHEMBL585654CHEMBL:CHEMBL457504BENSERAZIDE HYDROCHLORIDEHYPERICINCOUMESTROLCHEMBL:CHEMBL1519374INDIGOXANTHOANGELOLCHEMBL:CHEMBL1402376CHEMBL:CHEMBL586000BCR-ABL INHIBITOR GNF-2CHEMBL:CHEMBL458094AHPNCHEMBL:CHEMBL527584CHEMBL:CHEMBL2094456CHEMBL:CHEMBL1984884BILIRUBINPYRANTEL PAMOATECHEMBL:CHEMBL606167ACITRETINOMEPRAZOLECHEMBL:CHEMBL1224755EPINEPHRINE BITARTRATECARNOSIC ACIDCHEMBL:CHEMBL17201EPALRESTATSULFASALAZINECHEMBL:CHEMBL580421CGP53353CHEMBL:CHEMBL601192LANSOPRAZOLETRICLABENDAZOLEAPOMORPHINE HYDROCHLORIDE HEMIHYDRATECHEMBL:CHEMBL585656TYRPHOSTIN 47ZK-93423METHYLDOPA (RACEMIC)MECYSTEINE HYDROCHLORIDECHEMBL:CHEMBL242171CHEMBL:CHEMBL343002CHEMBL:CHEMBL126804GEFITINIBCHEMBL:CHEMBL580183CHEMBL:CHEMBL538542CHEMBL:CHEMBL586031CHEMBL:CHEMBL2181039DIAMIDEQUERCETINCHEMBL:CHEMBL600747FLUPIRTINE MALEATEDIHYDROGAMBOGIC ACIDCHEMBL:CHEMBL528181CHEMBL:CHEMBL602969CHEMBL:CHEMBL1379900AGROCLAVINE3-METHYLCHOLANTHRENECHEMBL:CHEMBL538104CHEMBL:CHEMBL605077CHEMBL:CHEMBL601952CHEMBL:CHEMBL578294THIOLUTINIDARUBICINETHOPROPAZINE HYDROCHLORIDEBEPRANEMABCHOLECALCIFEROLOXOPURPUREINENITAZOXANIDECHEMBL:CHEMBL601605CHEMBL:CHEMBL603952CHEMBL:CHEMBL590691S(+)-APOMORPHINEAURINTRICARBOXYLIC ACIDLAPACHOL4,4'-DIMETHOXYDALBERGIONERACEPINEPHRINECHEMBL:CHEMBL548017&ALPHA-ERGOCRYPTINEHYDROXYZINE PAMOATECHEMBL:CHEMBL546576PROTOPORPHYRINOBTUSAQUINONE3,4-DIMETHOXYDALBERGIONESEMAXANIBPICEATANNOLCHEMBL:CHEMBL85194DAUNORUBICIN LIPOSOMALDAMNACANTHALFUMARPROTOCETRARIC ACIDMAHANIMBINESAPPANONE A DIMETHYL ETHERCHEMBL:CHEMBL1498652PURPURINNPPBCHEMBL:CHEMBL527620ETHACRIDINE LACTATEGETIACAULEINIODOPHTHALEINPHENSERINEPIPLARTINEFISETINCHEMBL:CHEMBL339587RO31-8220CHEMBL:CHEMBL1465049CHEMBL:CHEMBL462861TYRPHOSTIN 25CARBIDOPA ANHYDROUSHARMALOLCHEMBL:CHEMBL582715CHEMBL:CHEMBL1939691CHEMBL:CHEMBL139935LINOLENIC ACIDCHEMBL:CHEMBL578504METHYSERGIDE MALEATEELLAGIC ACIDCHEMBL:CHEMBL399530CHEMBL:CHEMBL515252TRIBROMSALANCHEMBL:CHEMBL1334191EPINEPHRINEEMODINPOMIFERIN9,10-PHENANTHRENEQUINONECHEMBL:CHEMBL99408PANTOPRAZOLE SODIUMSAPPANONE A TRIMETHYL ETHERCHEMBL:CHEMBL1574420CHEMBL:CHEMBL1588679CHEMBL:CHEMBL585591CHEMBL:CHEMBL586078CHEMBL:CHEMBL595227Z-PRO-PROLINALTYRPHOSTIN B48HEMATOXYLINDICHLOROPHENAROMATICINOXOGLAUCINECEFACLOR ANHYDROUSCHEMBL:CHEMBL1601846CHEMBL:CHEMBL523200CHEMBL:CHEMBL297304SU9516PLUMBAGINDIHYDROERGOCRISTINE MESYLATEGW282974XCHEMBL:CHEMBL68534RALOXIFENE HYDROCHLORIDEISOGINKGETINZAPACHEMBL:CHEMBL1257092CHEMBL:CHEMBL77387CARUBICINHOMIDIUMMACLURAXANTHONEMETHYLENE BLUE ANHYDROUSPD-980591,10-PHENANTHROLINELAPACHONECHEMBL:CHEMBL2181040SB 204741PHENOTHIAZINESTAUROSPORINE AGLYCONPBT-1033PD-169316ARACHIDONIC ACIDCHEMBL:CHEMBL1320453CHEMBL:CHEMBL2343383-METHOXYCATECHOLISOVELLERALTANSHINONE ICHEMBL:CHEMBL531322TRIMETREXATEOXIDOPAMINE HYDROCHLORIDEGARCINONE EARUNDINEVITAMIN K3ISOEUGENITOLVU0001171INAMRINONECHEMBL:CHEMBL578905CHEMBL:CHEMBL1609016CHEMBL:CHEMBL601110CHEMBL:CHEMBL312487SANGUINARIUM CHLORIDECHEMBL:CHEMBL525103CHEMBL:CHEMBL252417MASOPROCOLP-AMINOHIPPURATEMETHYLTHIONINIUM CHLORIDEDERRUBONETRICETINDOCONEXENTCYSTEAMINE HYDROCHLORIDECHEMBL:CHEMBL1412489AM404RESVERATROLL 755507CHELERYTHRINEOXYTETRACYCLINE ANHYDROUS1,2-NAPHTHOQUINONEDAPHMITOXANTRONE HYDROCHLORIDEAMSACRINE HYDROCHLORIDECHEMBL:CHEMBL2181046CHEMBL:CHEMBL196814GF109203XCHEMBL:CHEMBL5970353,4-DICHLOROISOCOUMARINISOLIQUIRITIGENINCHEMBL:CHEMBL1814509CONGO REDCHEMBL:CHEMBL222556BITHIONOLATE SODIUMCHEMBL:CHEMBL546597PITTSBURGH COMPOUND BCHEMBL:CHEMBL146710STREPTONIGRINPATULINNORSTICTIC ACIDCAFFEIC ACID PHENETHYL ESTERDIMETHYL GAMBOGATECHEMBL:CHEMBL184074KAEMPHEROLCHEMBL:CHEMBL493863RATANIAPHENOL IISANGUINARIUMCHEMBL:CHEMBL601140JUGLONEPYRROLIDINE DITHIOCARBAMIC ACID, AMMONIUM SALT4-METHOXYDALBERGIONECHEMBL:CHEMBL580155N-OLEOYLDOPAMINE
Interaction Protein
ENSG00000010810ENSG00000082701ENSG00000103266ENSG00000109971ENSG00000134308ENSG00000142192ENSG00000142208ENSG00000146648ENSG00000164924ENSG00000185624ENSG00000275700
Interaction Count
11
Interaction Dataset
intact_biogrid