Protein detail
LAMC1
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)
Entry name LAMC1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)
Protein Class (4)
Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function (3)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
LAMB2
Gene Description
Laminin subunit gamma 1
Chromosome
1
Position
183023420-183145592
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization8
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificMAIT T-cellBlood Lineage SpecificB-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway7
Protein Function (3)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Predicted intracellular proteins
Cellular Component (10)
- GO:0005576 extracellular region
- GO:0005604 basement membrane
- GO:0005606 laminin-1 complex
- GO:0005615 extracellular space
- GO:0005788 endoplasmic reticulum lumen
- GO:0043259 laminin-10 complex
- GO:0043260 laminin-11 complex
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
- GO:0098637 protein complex involved in cell-matrix adhesion
Molecular Function (2)
Biological Process (3)
KEGG (10)
- hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa05020 Prion disease
- KEGG:hsa05145 Toxoplasmosis
- KEGG:hsa05146 Amoebiasis
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05222 Small cell lung cancer
Reactome (22)
- R-hsa-9638630 attachment of bacteria to epithelial cells
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1474228 degradation of the extracellular matrix
- R-hsa-9734767 developmental cell lineages
- R-hsa-9820448 developmental cell lineages of the exocrine pancreas
- R-hsa-9925563 developmental lineage of pancreatic ductal cells
- R-hsa-3000178 ecm proteoglycans
- R-hsa-9619665 egr2 and sox10 mediated initiation of schwann cell myelination
- R-hsa-1474244 extracellular matrix organization
- R-hsa-9913351 formation of the dystrophin glycoprotein complex dgc
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Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence43
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LAMC1 | CHEK1 | O14757 | T | 258 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | Yes | No | No |
| ecm | ecm | Ramilowski_location | Yes | No | Yes | No | No |
| basement membrane | ecm | Ramilowski_location | Yes | No | Yes | No | No |
| ecm | ecm | UniProt_location | Yes | No | Yes | No | No |
| laminin | ecm | HGNC | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
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Protein Complex Composition (16)
16 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Laminin-1 | LAMA1LAMB1LAMC1 | P07942P11047P25391 | 1:1:1 | SIGNORComplexPortal | intact:EBI-2529702SIGNOR:SIGNOR-C183 | 1745370914755292 |
| Laminin-10 | LAMA5LAMB1LAMC1 | O15230P07942P11047 | 2:2:2 | SIGNORCompleatComplexPortalPDB | SIGNOR:SIGNOR-C182Compleat:HC3280PDB:5xauintact:EBI-2529959 | 17453709147552921096450016236823 |
| Laminin-121 complex | LAMA1LAMB2LAMC1 | P11047P25391P55268 | 1:1:1 | ComplexPortal | intact:EBI-2529791 | 1745370914755292 |
| Laminin-211 complex | LAMA2LAMB1LAMC1 | P07942P11047P24043 | 1:1:1 | ComplexPortal | intact:EBI-2529716 | 1745370914755292 |
| Laminin-221 complex | LAMA2LAMB2LAMC1 | P11047P24043P55268 | 1:1:1 | ComplexPortal | intact:EBI-2529805 | 1745370914755292 |
| Laminin-311 complex variant A | LAMA3LAMB1LAMC1 | P07942P11047Q16787 | 1:1:1 | ComplexPortal | intact:EBI-9664043intact:EBI-2529903 | 1745370914755292 |
| Laminin-321 complex | LAMA3LAMB2LAMC1 | P11047P55268Q16787 | 1:1:1 | ComplexPortal | intact:EBI-2529917 | 1745370914755292 |
| laminin-11 complex | LAMA5LAMB2LAMC1 | O15230P11047P55268 | 1:1:1 | CompleatComplexPortal | Compleat:HC2958intact:EBI-2529973 | 174537091475529216236823 |
| AGAEEA1LAMA5LAMB1LAMB2LAMB4LAMC1 | A4D0S4O15230P07942P11047P20933P55268Q15075 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| AGAEEA1LAMA5LAMB1LAMB2LAMB4LAMC1UGGT2 | A4D0S4O15230P07942P11047P20933P55268Q15075Q9NYU1 | 0:0:0:0:0:0:0:0 | hu.MAP2 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37886648 |
Sequence, Structure & Domains9
Sequences
Length
1,609
Mass
177,603
Sequence
MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAGYLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEKP
3D Structural Models
Helix
1536..1552; 1554..1595
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Coiled Coil
1038..1609
Domain (CC)
The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.; DOMAIN: Domains VI and IV are globular.
Domain (FT)
46..285; Laminin N-terminal; 286..341; Laminin EGF-like 1; 342..397; Laminin EGF-like 2; 398..444; Laminin EGF-like 3; 445..494; Laminin EGF-like 4; 495..504; Laminin EGF-like 5; first part; 514..689; Laminin IV type A; 690..723; Laminin EGF-like 5; second part; 724..772; Laminin EGF-like 6; 773..827; Laminin EGF-like 7; 828..883; Laminin EGF-like 8; 884..934; Laminin EGF-like 9; 935..982; Laminin EGF-like 10; 983..1030; Laminin EGF-like 11
Region
1030..1609; Domain II and I
Clinical Relevance6
Disease Involvement
Cancer-related genes
Drugs
Interaction Protein (3)
ENSG00000087303ENSG00000116663ENSG00000143553
Interaction Count
3
Interaction Dataset (2)
biogrid_bioplexintact_biogrid
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 29148239 | Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants. | No abstract available |
| 30408591 | Portrait of blood-derived extracellular vesicles in patients with Parkinson's disease. | No abstract available |
| 34186243 | A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis. | No abstract available |
| 39409015 | SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy. | No abstract available |