Protein detail
LAMC1
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)
Protein symbol LAMC1 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins |
Basic Information
Protein Names
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)
Protein Class
Cancer-related genesPlasma proteinsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
LAMB2
Gene Description
Laminin subunit gamma 1
Chromosome
1
Position
183023420-183145592
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificMAIT T-cellBlood Lineage SpecificB-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Predicted intracellular proteins
Cellular Component
- GO:0005576 extracellular region
- GO:0005604 basement membrane
- GO:0005606 laminin-1 complex
- GO:0005615 extracellular space
- GO:0005788 endoplasmic reticulum lumen
- GO:0043259 laminin-10 complex
- GO:0043260 laminin-11 complex
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
- GO:0098637 protein complex involved in cell-matrix adhesion
Molecular Function
Biological Process
KEGG
- hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04512 ECM-receptor interaction
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa05020 Prion disease
- KEGG:hsa05145 Toxoplasmosis
- KEGG:hsa05146 Amoebiasis
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05222 Small cell lung cancer
Reactome
- R-hsa-9638630 attachment of bacteria to epithelial cells
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1474228 degradation of the extracellular matrix
- R-hsa-9734767 developmental cell lineages
- R-hsa-9820448 developmental cell lineages of the exocrine pancreas
- R-hsa-9925563 developmental lineage of pancreatic ductal cells
- R-hsa-3000178 ecm proteoglycans
- R-hsa-9619665 egr2 and sox10 mediated initiation of schwann cell myelination
- R-hsa-1474244 extracellular matrix organization
- R-hsa-9913351 formation of the dystrophin glycoprotein complex dgc
- R-hsa-9640148 infection with enterobacteria
- R-hsa-5663205 infectious disease
- R-hsa-373760 l1cam interactions
- R-hsa-3000157 laminin interactions
- R-hsa-8874081 met activates ptk2 signaling
- R-hsa-8875878 met promotes cell motility
- R-hsa-9675108 nervous system development
- R-hsa-3000171 non integrin membrane ecm interactions
- R-hsa-597592 post translational protein modification
- R-hsa-381426 regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps
- R-hsa-6806834 signaling by met
- R-hsa-9006934 signaling by receptor tyrosine kinases
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| LAMC1 | CHEK1 | O14757 | T | 258 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| matrix_adhesion | matrix_adhesion | Zhong2015 | No | Yes | Yes | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | No | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| ecm | ecm | CellChatDB | Yes | No | Yes | No | No |
| glycoprotein | ecm | Matrisome | Yes | No | Yes | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
16 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Laminin-1 | LAMA1LAMB1LAMC1 | P07942P11047P25391 | 1:1:1 | SIGNORComplexPortal | intact:EBI-2529702SIGNOR:SIGNOR-C183 | 1745370914755292 |
| Laminin-10 | LAMA5LAMB1LAMC1 | O15230P07942P11047 | 2:2:2 | SIGNORCompleatComplexPortalPDB | SIGNOR:SIGNOR-C182Compleat:HC3280PDB:5xauintact:EBI-2529959 | 17453709147552921096450016236823 |
| Laminin-121 complex | LAMA1LAMB2LAMC1 | P11047P25391P55268 | 1:1:1 | ComplexPortal | intact:EBI-2529791 | 1745370914755292 |
| Laminin-211 complex | LAMA2LAMB1LAMC1 | P07942P11047P24043 | 1:1:1 | ComplexPortal | intact:EBI-2529716 | 1745370914755292 |
| Laminin-221 complex | LAMA2LAMB2LAMC1 | P11047P24043P55268 | 1:1:1 | ComplexPortal | intact:EBI-2529805 | 1745370914755292 |
| Laminin-311 complex variant A | LAMA3LAMB1LAMC1 | P07942P11047Q16787 | 1:1:1 | ComplexPortal | intact:EBI-9664043intact:EBI-2529903 | 1745370914755292 |
| Laminin-321 complex | LAMA3LAMB2LAMC1 | P11047P55268Q16787 | 1:1:1 | ComplexPortal | intact:EBI-2529917 | 1745370914755292 |
| laminin-11 complex | LAMA5LAMB2LAMC1 | O15230P11047P55268 | 1:1:1 | CompleatComplexPortal | Compleat:HC2958intact:EBI-2529973 | 174537091475529216236823 |
| AGAEEA1LAMA5LAMB1LAMB2LAMB4LAMC1 | A4D0S4O15230P07942P11047P20933P55268Q15075 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| AGAEEA1LAMA5LAMB1LAMB2LAMB4LAMC1UGGT2 | A4D0S4O15230P07942P11047P20933P55268Q15075Q9NYU1 | 0:0:0:0:0:0:0:0 | hu.MAP2 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
1,609
Mass
177,603
Sequence
MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVFRLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAGYLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQAFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGNLAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAERHKQEADDIVRVAKTANDTSTEAYNLLLRTLAGENQTAFEIEELNRKYEQAKNISQDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLENEANNIKMEAENLEQLIDQKLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQEANDILNNLKDFDRRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEAKNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDADQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDLNKLNEIEGTLNKAKDEMKVSDLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSGCFNTPSIEKP
3D Structural Models
Helix
1536..1552; 1554..1595
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Coiled Coil
1038..1609
Domain (CC)
The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.; DOMAIN: Domains VI and IV are globular.
Domain (FT)
46..285; Laminin N-terminal; 286..341; Laminin EGF-like 1; 342..397; Laminin EGF-like 2; 398..444; Laminin EGF-like 3; 445..494; Laminin EGF-like 4; 495..504; Laminin EGF-like 5; first part; 514..689; Laminin IV type A; 690..723; Laminin EGF-like 5; second part; 724..772; Laminin EGF-like 6; 773..827; Laminin EGF-like 7; 828..883; Laminin EGF-like 8; 884..934; Laminin EGF-like 9; 935..982; Laminin EGF-like 10; 983..1030; Laminin EGF-like 11
Region
1030..1609; Domain II and I
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs
Interaction Protein
ENSG00000087303ENSG00000116663ENSG00000143553
Interaction Count
3
Interaction Dataset
biogrid_bioplexintact_biogrid