Protein detail

EPB41

Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)

Protein symbol EPB41	UniProt ID P11171	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) (Erythrocyte membrane protein band 4.1)

Protein Class

Disease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Predicted intracellular proteins
Human disease related genes:Cardiovascular diseases:Hematologic diseases
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Ensembl

ENSG00000159023

Entrez Gene Symbol

EPB41

Gene Synonym

4.1REL1

Gene Description

Erythrocyte membrane protein band 4.1

Chromosome

Position

28887091-29120046

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificCholangiocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificnaive CD8 T-cell

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Cardiovascular diseases:Hematologic diseases
Potential drug targets
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

15 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
EPB41	PRKCB	P05771	S	486	phosphorylation	KEA	KEA:15611095
EPB41	PRKCB	P05771	S	543	phosphorylation	KEA	KEA:15611095
EPB41	PRKCA	P17252	S	312	phosphorylation	PhosphoSite
EPB41	PRKCA	P17252	S	331	phosphorylation	PhosphoSite
EPB41	ERBB2	P04626	Y	660	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ferm_domain	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EGFR	P00533	EPB41	P11171	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDCui2007CA1WangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos	HPRD-phos:1647028 dbPTM:1647028 PhosphoSite:1647028 dbPTM:2171679 HPRD:1647028 SIGNOR:1647028 phosphoELM:1647028 KEA:1647028 CA1:1647028 ProtMapper:1647028
EPB41	P11171	DLG1	Q12959	Yes	Yes	No	SIGNORHPRDCui2007CA1Wang	SIGNOR:12807908 CA1:7937897 HPRD:7937897
EPB41	P11171	NUMA1	Q14980	Yes	Yes	No	HPRDHINTLit-BM-17SIGNOR	HINT:35271311 HINT:10189366 SIGNOR:23870127 Lit-BM-17:10189366 HPRD:10189366
KPCA	P17252	EPB41	P11171	Yes	No	No	PhosphoSite	PhosphoSite:21542582 PhosphoSite:2171679
CDK1	P06493	EPB41	P11171	Yes	No	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperdbPTMREACH_ProtMapperPhosphoSite	dbPTM:18220336 dbPTM:15525677 dbPTM:2171679 PhosphoSite:15525677 ProtMapper:15525677 dbPTM:18669648

Protein Complex Composition

16 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
DVL3 EPB41L4A FOXK1 FOXK2 NXN	P85037 Q01167 Q6DKJ4 Q92997 Q9HCS5	0:0:0:0:0	hu.MAP2
DVL3 EPB41L4A FOXK2	Q01167 Q92997 Q9HCS5	0:0:0	hu.MAP2
BLTP3A CHD9 EPB41L5	Q3L8U1 Q6BDS2 Q9HCM4	0:0:0	hu.MAP2
BLTP3A CHD9 EPB41L5 HECTD1	Q3L8U1 Q6BDS2 Q9HCM4 Q9ULT8	0:0:0:0	hu.MAP2
BLTP3A EPB41L5 HECTD1	Q6BDS2 Q9HCM4 Q9ULT8	0:0:0	hu.MAP2
EPB41L3 KRT222	Q8N1A0 Q9Y2J2	0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	3	28986585 27894104 38321535

Sequence, Structure & Domains

Sequences

Length

864

Mass

97,017

Sequence

MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=P11171-1; Sequence=Displayed; Name=2; IsoId=P11171-2; Sequence=VSP_000470; Name=3; IsoId=P11171-3; Sequence=VSP_000468, VSP_000471; Name=4; Synonyms=Erythroid; IsoId=P11171-4; Sequence=VSP_000468, VSP_000470, VSP_000473; Name=5; Synonyms=Non-erythroid A; IsoId=P11171-5; Sequence=VSP_000469, VSP_000470, VSP_000472; Name=6; Synonyms=Non-erythroid B; IsoId=P11171-6; Sequence=VSP_000468, VSP_000469, VSP_000470, VSP_000472; Name=7; IsoId=P11171-7; Sequence=VSP_000471, VSP_012872, VSP_012873

Alternative Sequence

1..209; Missing (in isoform 3, isoform 4 and isoform 6); 228..262; Missing (in isoform 5 and isoform 6); 616..648; Missing (in isoform 2, isoform 4, isoform 5 and isoform 6); 635..648; Missing (in isoform 3 and isoform 7); 649..669; Missing (in isoform 5 and isoform 6); 729..734; PPLVKT -> VSTLST (in isoform 7); 735..864; Missing (in isoform 7); 772..805; Missing (in isoform 4)

3D Structural Models

Turn

275..277; 394..397

Helix

232..243; 248..250; 271..274; 293..295; 299..314; 322..337; 342..345; 350..352; 361..372; 379..390; 434..436; 470..486

Beta Strand

211..215; 221..225; 251..258; 261..264; 281..288; 356..358; 399..404; 410..415; 417..424; 427..433; 437..443; 446..451; 454..458; 461..466

3D Structure

NMR spectroscopy (1); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

1..16; Polar residues; 27..41; Polar residues; 61..75; Basic and acidic residues; 76..87; Low complexity; 101..117; Basic and acidic residues; 149..158; Polar residues; 182..199; Basic and acidic residues; 587..600; Basic and acidic residues; 601..610; Acidic residues

Domain (FT)

210..491; FERM

Region

1..122; Disordered; 136..170; Disordered; 182..202; Disordered; 494..614; Hydrophilic; 518..572; Disordered; 586..611; Disordered; 615..713; Spectrin--actin-binding; 714..864; C-terminal (CTD)

Clinical Relevance

Disease Involvement

ElliptocytosisHereditary hemolytic anemiaPyropoikilocytosis

Drugs

NICOTINE POLACRILEX BUPROPION HYDROCHLORIDE SILMITASERTIB

Antibody

HPA028076 HPA028096 HPA028412 HPA028414

Interaction Protein

ENSG00000170027

Interaction Count

Interaction Dataset

intact_biogrid