Protein detail
LAMP1
Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)
Protein symbol LAMP1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersPlasma proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)
Protein Class
CD markersPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- CD markers
Transmembrane
383..410; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD107a
Gene Description
Lysosomal associated membrane protein 1
Chromosome
13
Position
113297239-113323672
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificLate spermatidsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Transporters
- CD markers
Cellular Component
- GO:0000421 autophagosome membrane
- GO:0005737 cytoplasm
- GO:0005764 lysosome
- GO:0005765 lysosomal membrane
- GO:0005770 late endosome
- GO:0005771 multivesicular body
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0008021 synaptic vesicle
- GO:0009897 external side of plasma membrane
- GO:0010008 endosome membrane
- GO:0016020 membrane
- GO:0031902 late endosome membrane
- GO:0035577 azurophil granule membrane
- GO:0042383 sarcolemma
- GO:0042470 melanosome
- GO:0044754 autolysosome
- GO:0048471 perinuclear region of cytoplasm
- GO:0061474 phagolysosome membrane
- GO:0070062 extracellular exosome
- GO:0101003 ficolin-1-rich granule membrane
- GO:0101004 cytolytic granule membrane
Molecular Function
Biological Process
KEGG
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AP3B1AP3D1AP3M1AP3S1ARF1LAMP1 | O00203O14617P11279P84077Q92572Q9Y2T2 | 2:2:2:4:2:2 | PDB | PDB:9c5bPDB:9c59 | ||
| AP3B1AP3M1ARF1LAMP1 | O00203P11279P84077Q9Y2T2 | 2:2:2:2 | PDB | PDB:9c5a | ||
| LAMP1STK17B | O94768P11279 | 0:0 | hu.MAP2 | |||
| LAMP1 | P11279 | 2 | PDB | PDB:8ath | ||
| LAMP1TMEM175 | P11279Q9BSA9 | 2:2 | PDB | PDB:8fyfPDB:8fy5 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38673823 |
Sequence, Structure & Domains
Sequences
Length
417
Mass
44,882
Sequence
MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11279-1; Sequence=Displayed; Name=2; IsoId=P11279-2; Sequence=VSP_056032
Alternative Sequence
135..187; Missing (in isoform 2)
3D Structural Models
Turn
75..77; 83..85; 95..97; 125..127
Helix
192..194; 384..409
Beta Strand
30..34; 40..56; 59..66; 89..94; 98..106; 108..121; 136..141; 146..148; 151..157; 159..163; 166..178; 180..183; 188..190
3D Structure
Electron microscopy (5); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
199..215; Pro residues
Region
29..194; First lumenal domain; 184..221; Disordered; 195..227; Hinge; 228..382; Second lumenal domain
Protein Families
LAMP family
Sequence Similarities
Belongs to the LAMP family.
Clinical Relevance
Drugs
Interaction Protein
ENSG00000049245ENSG00000075785ENSG00000079950ENSG00000099940ENSG00000115806ENSG00000117758ENSG00000124333ENSG00000170088
Interaction Count
8
Interaction Dataset
biogrid_opencell