Protein detail

LAMP1

Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)

Protein symbol LAMP1	UniProt ID P11279	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (CD antigen CD107a)

Protein Class

CD markersPlasma proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters
CD markers

Transmembrane

383..410; Helical

Transmembrane Count

Ensembl

ENSG00000185896

Entrez Gene Symbol

LAMP1

Gene Synonym

CD107a

Gene Description

Lysosomal associated membrane protein 1

Chromosome

Position

113297239-113323672

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificLate spermatidsSingle-Nuclei Brain SpecificastrocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Transporters
CD markers

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Cellinker	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AP3B1 AP3D1 AP3M1 AP3S1 ARF1 LAMP1	O00203 O14617 P11279 P84077 Q92572 Q9Y2T2	2:2:2:4:2:2	PDB	PDB:9c5bPDB:9c59
AP3B1 AP3M1 ARF1 LAMP1	O00203 P11279 P84077 Q9Y2T2	2:2:2:2	PDB	PDB:9c5a
LAMP1 STK17B	O94768 P11279	0:0	hu.MAP2
LAMP1	P11279	2	PDB	PDB:8ath
LAMP1 TMEM175	P11279 Q9BSA9	2:2	PDB	PDB:8fyfPDB:8fy5

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38673823

Sequence, Structure & Domains

Sequences

Length

417

Mass

44,882

Sequence

MAAPGSARRPLLLLLLLLLLGLMHCASAAMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11279-1; Sequence=Displayed; Name=2; IsoId=P11279-2; Sequence=VSP_056032

Alternative Sequence

135..187; Missing (in isoform 2)

3D Structural Models

Turn

75..77; 83..85; 95..97; 125..127

Helix

192..194; 384..409

Beta Strand

30..34; 40..56; 59..66; 89..94; 98..106; 108..121; 136..141; 146..148; 151..157; 159..163; 166..178; 180..183; 188..190

3D Structure

Electron microscopy (5); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

199..215; Pro residues

Region

29..194; First lumenal domain; 184..221; Disordered; 195..227; Hinge; 228..382; Second lumenal domain

Protein Families

LAMP family

Sequence Similarities

Belongs to the LAMP family.

Clinical Relevance

Drugs

DIMETHYL SULFOXIDE

Antibody

CAB004260 HPA014750

Interaction Protein

ENSG00000049245ENSG00000075785ENSG00000079950ENSG00000099940ENSG00000115806ENSG00000117758ENSG00000124333ENSG00000170088

Interaction Count

Interaction Dataset

biogrid_opencell