Protein detail

KPSH1

Serine/threonine-protein kinase H1 (EC 2.7.11.1) (Protein serine kinase H1) (PSK-H1)

Entry name KPSH1	UniProt ID P11801	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification EnzymesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Serine/threonine-protein kinase H1 (EC 2.7.11.1) (Protein serine kinase H1) (PSK-H1)

Protein Class (2)

EnzymesPredicted membrane proteins

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Kinases:CAMK Ser/Thr protein kinases

Ensembl

ENSG00000159792

Entrez Gene Symbol

PSKH1

Gene Description

Protein serine kinase H1

Chromosome

Position

67893254-67929676

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization7

Tissue Specificadipose tissueCell SpecificAlveolar cells type 1Single-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificmyeloid DCBlood Lineage Specificdendritic cellsSecretome LocationIntracellular and membraneSecretome FunctionCell adhesion

Function & Pathway5

Protein Function (3)

ENZYME proteins:Transferases
Enzymes
Kinases:CAMK Ser/Thr protein kinases

Cellular Component (7)

Molecular Function (5)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence13

Ligand-Receptor Signaling (12)

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingELISA	4	38731868 40784529 40098346 41201090

Sequence, Structure & Domains8

Sequences

Length

424

Mass

48,035

Sequence

MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAHPCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQQYNG

Domain & Motif Annotations

Compositional Bias

385..398; Low complexity

Domain (FT)

98..355; Protein kinase

Region

56..80; Disordered; 378..407; Disordered

Protein Families (2)

Protein kinase superfamily
CAMK Ser/Thr protein kinase family

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Clinical Relevance2

Disease Involvement (2)

Disease variantIntrahepatic cholestasis

Antibody (2)

HPA053927 HPA062763

Supporting Publications1

PMID	Title	Abstract
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available