Protein detail
EF2
Elongation factor 2 (EF-2) (EC 3.6.5.-)
Entry name EF2 | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 35 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEssential proteinsFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Elongation factor 2 (EF-2) (EC 3.6.5.-)
Protein Class (8)
Cancer-related genesDisease related genesEssential proteinsFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Biotech drugs
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
EEF-2EF2
Gene Description
Eukaryotic translation elongation factor 2
Chromosome
19
Position
3976056-3985463
Supporting publications (n)
35
EVMP confidence score
0.75
Fluorescence & Localization5
Tissue Specificlymphoid tissueCell SpecificAstrocytesSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Cancer-related genes:Candidate cancer biomarkers
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component (13)
- GO:0005576 extracellular region
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005840 ribosome
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016235 aggresome
- GO:0034774 secretory granule lumen
- GO:0045202 synapse
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Molecular Function (8)
Biological Process (3)
Reactome (12)
- R-hsa-9824439 bacterial infection pathways
- R-hsa-156842 eukaryotic translation elongation
- R-hsa-163841 gamma carboxylation hypusinylation hydroxylation and arylsulfatase activation
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-6798695 neutrophil degranulation
- R-hsa-597592 post translational protein modification
- R-hsa-8876725 protein methylation
- R-hsa-5358493 synthesis of diphthamide eef2
- R-hsa-72766 translation
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Mediation Categories (3)
Clinical-translation mediationImmune mediationMetabolism mediation
Relations & Evidence51
Enzyme-Mediated Modification (23)
23 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EEF2 | CDK1 | P06493 | S | 595 | phosphorylation | PhosphoSite | |
| EEF2 | CDK1 | P06493 | S | 360 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:24958351 |
| EEF2 | CDK2 | P24941 | T | 435 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| EEF2 | CDK2 | P24941 | S | 595 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:23184662ProtMapper:24958351ProtMapper:24167567 |
| EEF2 | NEK2 | P51955 | S | 595 | phosphorylation | PhosphoSite | |
| EEF2 | EGF | P01133 | T | 57 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| EEF2 | HTR2C | P28335 | T | 57 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:27821870 |
| EEF2 | TRPM7 | Q96QT4 | T | 57 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21112387 |
| EEF2 | PREP | P48147 | T | 57 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:29371602 |
| EEF2 | NUP214 | P35658 | T | 57 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:18728285 |
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (5)
5 records.
Protein Complex Composition (14)
14 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ABHD11BCAT2EEF2KMTLMAN2YBEY | O15382P58557Q12907Q8NFV4Q96G04 | 0:0:0:0:0 | hu.MAP2 | |||
| DDX17DHX15EEF2 | O43143P13639Q92841 | 0:0:0 | hu.MAP2 | |||
| ATP6V1HEEF2PNPLA6TIMM9 | P13639Q8IY17Q9UI12Q9Y5J7 | 0:0:0:0 | hu.MAP2 | |||
| EEF2KMT | Q96G04 | 3 | PDB | PDB:8fzb |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryR Sequencing | 1 | 37886648 |
Sequence, Structure & Domains7
Sequences
Length
858
Mass
95,338
Sequence
MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL
3D Structural Models
3D Structure
Electron microscopy (18)
Domain & Motif Annotations
Domain (FT)
17..362; tr-type G
Protein Families (3)
- TRAFAC class translation factor GTPase superfamily
- Classic translation factor GTPase family
- EF-G/EF-2 subfamily
Sequence Similarities
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Clinical Relevance7
Disease Involvement (5)
Cancer-related genesDisease variantFDA approved drug targetsNeurodegenerationSpinocerebellar ataxia
Drug Targets
FDA approved drug targets
Drugs (18)
RESIMMUNELMB-100DANUSERTIBTAGRAXOFUSP-ERZSCYCLOHEXIMIDEOPORTUZUMAB MONATOX(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDECOMPOUND 38 [PMID: 20817473]LACTIMIDOMYCINMOXETUMOMAB PASUDOTOXSS1(DSFV)-PE38AMG-900MK-5108GSK1070916ILORASERTIBTOZASERTIBBI-847325DENILEUKIN DIFTITOX
Interaction Protein (2)
ENSG00000072506ENSG00000174444
Interaction Count
2
Interaction Dataset (2)
intact_biogridbiogrid_opencell
Supporting Publications35
| PMID | Title | Abstract |
|---|---|---|
| 26098714 | Ionizing radiation affects protein composition of exosomes secreted in vitro from head and neck squamous cell carcinoma. | No abstract available |
| 26826536 | [Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles]. | No abstract available |
| 28680152 | Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity. | No abstract available |
| 31617158 | Proteomic profiling of peritoneal dialysis effluent-derived extracellular vesicles: a longitudinal study. | No abstract available |
| 31805958 | Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment. | No abstract available |
| 32106990 | Characterization of exosomes in peritoneal fluid of endometriosis patients. | No abstract available |
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No abstract available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 32854315 | Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. | Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD. |
| 32916986 | Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines. | No abstract available |
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