Protein detail

SC5A1

Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)

Entry name SC5A1	UniProt ID P13866	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 14	Protein classification Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)

Protein Class (7)

Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
FDA approved drug targets:Small molecule drugs

Transmembrane

25..47; Helical; Name=TM0; 67..90; Helical; Name=TM1; 96..117; Helical; Name=TM2; 140..169; Helical; Name=TM3; 177..193; Helical; Name=TM4; 203..221; Helical; Name=TM5; 276..295; Helical; Name=TM6; 310..331; Helical; Name=TM7; 376..406; Helical; Name=TM8; 423..444; Helical; Name=TM9; 452..477; Helical; Name=TM10; 482..504; Helical; Name=TM11; 526..547; Helical; Name=TM12; 645..662; Helical; Name=TM13

Transmembrane Count

Ensembl

ENSG00000100170

Entrez Gene Symbol

SLC5A1

Gene Synonym (3)

D22S675NAGTSGLT1

Gene Description

Solute carrier family 5 member 1

Chromosome

Position

32043261-32113029

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificeosinophil

Function & Pathway7

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
FDA approved drug targets:Small molecule drugs

Cellular Component (8)

Molecular Function (10)

Biological Process (3)

KEGG (3)

Reactome (7)

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence31

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
extracellular	extracellular	DGIdb	No	No	No	No	No
extracellular	extracellular	LOCATE	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transporter	transporter	Surfaceome	No	Yes	No	No	No
slc5	transporter	Surfaceome	No	Yes	No	No	No

Page 1 of 3Next

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PDZK1IP1 SLC5A1	P13866 Q13113	1:1	PDB	PDB:7yniPDB:7wmv

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	32301581

Sequence, Structure & Domains12

Sequences

Length

664

Mass

73,498

Sequence

MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13866-1; Sequence=Displayed; Name=2; IsoId=P13866-2; Sequence=VSP_044782

Alternative Sequence

1..127; Missing (in isoform 2)

3D Structural Models

Turn

26..28; 76..78; 79..81; 122..124; 196..198; 227..229; 260..263; 269..271; 448..450; 553..558; 562..565

Helix

22..24; 29..46; 55..58; 67..75; 86..93; 97..101; 102..114; 117..121; 129..135; 140..156; 158..172; 178..193; 202..225; 230..236; 253..255; 276..292; 296..301; 308..320; 321..323; 325..329; 330..338; 340..343; 348..355; 362..364; 365..371; 378..408; 410..412; 419..427; 430..444; 452..463; 465..476; 482..506; 528..545; 622..632; 641..663

Beta Strand

126..128; 265..267; 272..275; 304..307; 511..513; 519..524; 559..561

3D Structure

Electron microscopy (4)

Domain & Motif Annotations

Domain (CC)

The cholesterol-binding site is formed by transmembrane helices TM1, TM7 and TM13..

Protein Families

Sodium:solute symporter (SSF) (TC 2.A.21) family

Sequence Similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Clinical Relevance4

Disease Involvement (2)

Disease variantFDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs (6)

LICOGLIFLOZIN SOTAGLIFLOZIN STREPTOZOCIN NULL GSK-1614235 GLUFOSFAMIDE

Antibody (3)

CAB015467 HPA051805 HPA055106

Supporting Publications1

PMID	Title	Abstract
31718609	Ovarian cancer circulating extracelluar vesicles promote coagulation and have a potential in diagnosis: an iTRAQ based proteomic analysis.	No abstract available