Protein detail
SC5A1
Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)
Entry name SC5A1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 14 | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
- FDA approved drug targets:Small molecule drugs
Transmembrane
25..47; Helical; Name=TM0; 67..90; Helical; Name=TM1; 96..117; Helical; Name=TM2; 140..169; Helical; Name=TM3; 177..193; Helical; Name=TM4; 203..221; Helical; Name=TM5; 276..295; Helical; Name=TM6; 310..331; Helical; Name=TM7; 376..406; Helical; Name=TM8; 423..444; Helical; Name=TM9; 452..477; Helical; Name=TM10; 482..504; Helical; Name=TM11; 526..547; Helical; Name=TM12; 645..662; Helical; Name=TM13
Transmembrane Count
14
Ensembl
Entrez Gene Symbol
Gene Synonym
D22S675NAGTSGLT1
Gene Description
Solute carrier family 5 member 1
Chromosome
22
Position
32043261-32113029
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAstrocytesSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificeosinophil
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of carbohydrate metabolism
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0005354 galactose transmembrane transporter activity
- GO:0005367 myo-inositol:sodium symporter activity
- GO:0005372 water transmembrane transporter activity
- GO:0005412 D-glucose:sodium symporter activity
- GO:0005515 protein binding
- GO:0015146 pentose transmembrane transporter activity
- GO:0015150 fucose transmembrane transporter activity
- GO:0015151 alpha-glucoside transmembrane transporter activity
- GO:0015371 galactose:sodium symporter activity
- GO:0055056 D-glucose transmembrane transporter activity
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
29 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| apc | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 32301581 |
Sequence, Structure & Domains
Sequences
Length
664
Mass
73,498
Sequence
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P13866-1; Sequence=Displayed; Name=2; IsoId=P13866-2; Sequence=VSP_044782
Alternative Sequence
1..127; Missing (in isoform 2)
3D Structural Models
Turn
26..28; 76..78; 79..81; 122..124; 196..198; 227..229; 260..263; 269..271; 448..450; 553..558; 562..565
Helix
22..24; 29..46; 55..58; 67..75; 86..93; 97..101; 102..114; 117..121; 129..135; 140..156; 158..172; 178..193; 202..225; 230..236; 253..255; 276..292; 296..301; 308..320; 321..323; 325..329; 330..338; 340..343; 348..355; 362..364; 365..371; 378..408; 410..412; 419..427; 430..444; 452..463; 465..476; 482..506; 528..545; 622..632; 641..663
Beta Strand
126..128; 265..267; 272..275; 304..307; 511..513; 519..524; 559..561
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Domain (CC)
The cholesterol-binding site is formed by transmembrane helices TM1, TM7 and TM13..
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targets
Drug Targets
FDA approved drug targets