Protein detail

HCLS1

Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)

Protein symbol HCLS1	UniProt ID P14317	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000180353

Entrez Gene Symbol

HCLS1

Gene Synonym

CTTNLHS1

Gene Description

Hematopoietic cell-specific Lyn substrate 1

Chromosome

Position

121631399-121660927

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificB-cellsBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Mediation Categories

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

44 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
HCLS1	LYN	P07948	Y	378	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapper	ProtMapper:9104825 KEA:9104825 KEA:8578591 SIGNOR:9104825 KEA:96108162 phosphoELM:9104825 KEA:17570479
HCLS1	LYN	P07948	Y	222	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	phosphoELM:10066823 SIGNOR:10066823 ProtMapper:10066823 KEA:10066823
HCLS1	LYN	P07948	Y	397	phosphorylation	PhosphoNetworksSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapper	ProtMapper:9104825 ProtMapper:23001182 KEA:9104825 KEA:8578591 KEA:9183008 SIGNOR:9104825 KEA:96108162 phosphoELM:9104825
HCLS1	LYN	P07948	Y	360	phosphorylation	PhosphoNetworksKEA	KEA:17570479
HCLS1	SYK	P43405	Y	378	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:9104825 KEA:9104825 KEA:8578591 SIGNOR:9104825 KEA:96108162 phosphoELM:9104825 ProtMapper:25723543
HCLS1	SYK	P43405	Y	397	phosphorylation	PhosphoNetworksSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEAphosphoELMLi2012SIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:15795233 ProtMapper:23001182 KEA:9104825 ProtMapper:9104825 ProtMapper:21444687 KEA:8578591 KEA:9183008 SIGNOR:9104825 KEA:96108162 phosphoELM:9104825 ProtMapper:25723543
HCLS1	SYK	P43405	Y	360	phosphorylation	PhosphoNetworks
HCLS1	FGR	P09769	Y	222	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperPhosphoSite	SIGNOR:10066823 phosphoELM:10066823 ProtMapper:10066823 HPRD:10066823 dbPTM:10066823 dbPTM:8611520 KEA:10066823
HCLS1	FGR	P09769	Y	397	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEAphosphoELM	KEA:9104825 KEA:8578591 KEA:9183008 phosphoELM:9183008 KEA:96108162
HCLS1	FGR	P09769	Y	360	phosphorylation	PhosphoNetworks

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Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KSYK	P43405	HCLS1	P14317	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEALi2012PhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LCSPIKE	ProtMapper:15795233 ProtMapper:23001182 KEA:9104825 PhosphoSite:16782030 ProtMapper:9104825 ProtMapper:21444687 KEA:8578591 KEA:9183008 SIGNOR:9104825 PhosphoSite:9104825 SPIKE:15166239 SPIKE_LC:15166239 KEA:96108162 iPTMnet:9104825 ProtMapper:25723543 phosphoELM:9104825 PhosphoSite:18587398 HPRD:9104825
LYN	P07948	HCLS1	P14317	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAInnateDBDOMINOPhosphoNetworksHPRDWangPhosphoSite_ProtMapperNetworKIN_KEAphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperSPIKE_LCSPIKE	ProtMapper:9104825 phosphoELM:10066823 InnateDB:7682714 SIGNOR:10066823 ProtMapper:23001182 ProtMapper:10066823 SPIKE:7682714 iPTMnet:9104825 ProtMapper:30537294 HPRD:7682714 KEA:9183008 SIGNOR:9104825 HPRD:10066823 DOMINO:15795233 phosphoELM:9104825 SPIKE_LC:7682714 KEA:10066823 HPRD:9104825 KEA:9104825 KEA:8578591 KEA:96108162 SPIKE_LC:16713569 KEA:17570479 SPIKE_LC:15795233
FGR	P09769	HCLS1	P14317	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	SIGNOR:10066823 KEA:9104825 HPRD-phos:10066823 phosphoELM:10066823 KEA:8578591 KEA:9183008 ProtMapper:10066823 HPRD:10066823 phosphoELM:9183008 dbPTM:10066823 KEA:96108162 dbPTM:8611520 KEA:10066823
CSK21	P68400	HCLS1	P14317	Yes	Yes	No	WangPhosphoNetworksPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:10806407 HPRD:10806407 KEA:10806407 PhosphoSite:10806407 SIGNOR:10806407

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation；Acoustic trapping	R Sequencing	1	27487081

Sequence, Structure & Domains

Sequences

Length

486

Mass

54,014

Sequence

MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVAVYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14317-1; Sequence=Displayed; Name=2; IsoId=P14317-2; Sequence=VSP_056429, VSP_056430

Alternative Sequence

134..209; SAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSA -> ITLVALVAGTGWRRINGTKQLWDMTTRERRRNTSPREIMPRALVASMESRRTEWIRALSASMKWRPRPQLIRRRRP (in isoform 2); 210..486; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

243..276; Basic and acidic residues; 315..324; Basic and acidic residues; 353..383; Acidic residues; 390..405; Acidic residues; 406..419; Low complexity

Repeat

79..115; Cortactin 1; 116..152; Cortactin 2; 153..189; Cortactin 3; 190..212; Cortactin 4; truncated

Domain (FT)

428..486; SH3

Region

27..66; Involved in HAX-1 binding; 243..419; Disordered

Clinical Relevance

Antibody

HPA019143