Protein detail
HCLS1
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)
Protein symbol HCLS1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CTTNLHS1
Gene Description
Hematopoietic cell-specific Lyn substrate 1
Chromosome
3
Position
121631399-121660927
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificB-cellsBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
44 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| HCLS1 | CSNK2A1 | P68400 | T | 23 | phosphorylation | PhosphoNetworksPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:10806407ProtMapper:10806407KEA:10806407 |
| HCLS1 | CSNK2A1 | P68400 | T | 16 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:10806407ProtMapper:10806407KEA:10806407 |
| HCLS1 | SRC | P12931 | Y | 378 | phosphorylation | Li2012 | |
| HCLS1 | SRC | P12931 | Y | 397 | phosphorylation | Li2012 | |
| HCLS1 | DYRK1B | Q9Y463 | Y | 103 | phosphorylation | PhosphoNetworks | |
| HCLS1 | DYRK1B | Q9Y463 | Y | 140 | phosphorylation | PhosphoNetworks | |
| HCLS1 | FGFR4 | P22455 | Y | 103 | phosphorylation | PhosphoNetworks | |
| HCLS1 | FGFR4 | P22455 | Y | 140 | phosphorylation | PhosphoNetworks | |
| HCLS1 | WEE1 | P30291 | Y | 198 | phosphorylation | PhosphoNetworks | |
| HCLS1 | TNNI3K | Q59H18 | Y | 222 | phosphorylation | PhosphoNetworks |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KSYK | P43405 | HCLS1 | P14317 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEALi2012PhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LCSPIKE | ProtMapper:15795233ProtMapper:23001182KEA:9104825PhosphoSite:16782030ProtMapper:9104825ProtMapper:21444687KEA:8578591KEA:9183008SIGNOR:9104825PhosphoSite:9104825SPIKE:15166239SPIKE_LC:15166239KEA:96108162iPTMnet:9104825ProtMapper:25723543phosphoELM:9104825PhosphoSite:18587398HPRD:9104825 |
| LYN | P07948 | HCLS1 | P14317 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAInnateDBDOMINOPhosphoNetworksHPRDWangPhosphoSite_ProtMapperNetworKIN_KEAphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperSPIKE_LCSPIKE | ProtMapper:9104825phosphoELM:10066823InnateDB:7682714SIGNOR:10066823ProtMapper:23001182ProtMapper:10066823SPIKE:7682714iPTMnet:9104825ProtMapper:30537294HPRD:7682714KEA:9183008SIGNOR:9104825HPRD:10066823DOMINO:15795233phosphoELM:9104825SPIKE_LC:7682714KEA:10066823HPRD:9104825KEA:9104825KEA:8578591KEA:96108162SPIKE_LC:16713569KEA:17570479SPIKE_LC:15795233 |
| FGR | P09769 | HCLS1 | P14317 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos | SIGNOR:10066823KEA:9104825HPRD-phos:10066823phosphoELM:10066823KEA:8578591KEA:9183008ProtMapper:10066823HPRD:10066823phosphoELM:9183008dbPTM:10066823KEA:96108162dbPTM:8611520KEA:10066823 |
| CSK21 | P68400 | HCLS1 | P14317 | Yes | Yes | No | WangPhosphoNetworksPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:10806407HPRD:10806407KEA:10806407PhosphoSite:10806407SIGNOR:10806407 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Acoustic trapping | R Sequencing | 1 | 27487081 |
Sequence, Structure & Domains
Sequences
Length
486
Mass
54,014
Sequence
MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVAVYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14317-1; Sequence=Displayed; Name=2; IsoId=P14317-2; Sequence=VSP_056429, VSP_056430
Alternative Sequence
134..209; SAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSA -> ITLVALVAGTGWRRINGTKQLWDMTTRERRRNTSPREIMPRALVASMESRRTEWIRALSASMKWRPRPQLIRRRRP (in isoform 2); 210..486; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
243..276; Basic and acidic residues; 315..324; Basic and acidic residues; 353..383; Acidic residues; 390..405; Acidic residues; 406..419; Low complexity
Repeat
79..115; Cortactin 1; 116..152; Cortactin 2; 153..189; Cortactin 3; 190..212; Cortactin 4; truncated
Domain (FT)
428..486; SH3
Region
27..66; Involved in HAX-1 binding; 243..419; Disordered
Clinical Relevance
Antibody