Protein detail

PVR

Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)

Protein symbol PVR	UniProt ID P15151	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)

Protein Class

CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins
CD markers
Predicted intracellular proteins

Transmembrane

344..367; Helical

Transmembrane Count

Ensembl

ENSG00000073008

Entrez Gene Symbol

PVR

Gene Synonym

CD155HVEDNecl-5NECL5PVSTage4

Gene Description

PVR cell adhesion molecule

Chromosome

Position

44643798-44666162

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificneutrophil

Function & Pathway

Protein Function

Predicted secreted proteins
CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PVR	INSR	P06213	Y	398	phosphorylation	KEA	KEA:17570479
PVR	LCK	P06239	Y	398	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

64 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	Yes	Yes	No
secreted	secreted	UniProt_keyword	No	No	Yes	Yes	No
secreted	secreted	UniProt_location	No	No	Yes	Yes	No
secreted	secreted	HPA_secretome	No	No	Yes	Yes	No
secreted	secreted	connectomeDB2020	No	No	Yes	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MARH9	Q86YJ5	PVR	P15151	Yes	No	Yes	SIGNOR	SIGNOR:19457934
PVR	P15151	CD226	Q15762	Yes	Yes	No	CellChatDBSparser_ProtMapperCellPhoneDBUniProt_LRdbICELLNETSIGNORProtMapperconnectomeDB2020HPRDHINTWojtowicz2020IntActLit-BM-17WangLRdb	Lit-BM-17:12913096 ProtMapper:33670993 ICELLNET:15034010 HINT:30591568 HINT:21982860 IntAct:21982860 HINT:12913096 connectomeDB2020:15607800 IntAct:30591568 SIGNOR:30591568 HINT:31253644 Lit-BM-17:21982860 HPRD:12913096
PVR	P15151	TIGIT	Q495A1	Yes	Yes	No	CellChatDBCellPhoneDBUniProt_LRdbICELLNETSIGNORconnectomeDB2020HINTWojtowicz2020IntActLit-BM-17LRdb	connectomeDB2020:19815499 IntAct:21982860 HINT:21982860 ICELLNET:27192565 HINT:28515320 HINT:22421438 IntAct:28515320 Lit-BM-17:21982860 SIGNOR:30591568

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
NTHL1 PVR RAE1 RTCA ZC3HAV1	O00442 P15151 P78406 P78549 Q7Z2W4	0:0:0:0:0	Havugimana2012	Havugimana2012:C_473
C4A NLRX1 PVR TMEM183BP	P0C0L4 P15151 Q1AE95 Q86UT6	0:0:0:0	hu.MAP2
PVRIG SEC11A SEC11C SPCS1 SPCS2 SPCS3	P61009 P67812 Q15005 Q6DKI7 Q9BY50 Q9Y6A9	0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	31414377

Sequence, Structure & Domains

Sequences

Length

417

Mass

45,303

Sequence

MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=Alpha; IsoId=P15151-1; Sequence=Displayed; Name=Beta; IsoId=P15151-2; Sequence=VSP_002617; Name=Gamma; IsoId=P15151-3; Sequence=VSP_002618, VSP_002619; Name=Delta; IsoId=P15151-4; Sequence=VSP_002620, VSP_002621

Alternative Sequence

331; E -> G (in isoform Gamma); 332..384; Missing (in isoform Gamma); 340..384; Missing (in isoform Beta); 385..392; TEHASASA -> EHHQSCRN (in isoform Delta); 393..417; Missing (in isoform Delta)

3D Structural Models

Turn

80..82; 89..91

Helix

115..117

Beta Strand

30..32; 35..40; 45..47; 50..52; 60..68; 71..73; 75..79; 83..88; 92..96; 108..110; 119..128; 131..142; 146..151; 161..173; 176..180; 186..193; 200..208; 212..214; 218..224; 228..230; 232..237; 245..249; 262..269; 275..285; 290..293; 296..299; 310..315; 320..329

3D Structure

Electron microscopy (7); X-ray crystallography (6)

Domain & Motif Annotations

Motif

396..401; ITIM motif

Domain (CC)

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Domain (FT)

24..139; Ig-like V-type; 145..237; Ig-like C2-type 1; 244..328; Ig-like C2-type 2

Region

368..372; DYNLT1 binding

Protein Families

Nectin family

Sequence Similarities

Belongs to the nectin family.

Clinical Relevance

Antibody

HPA012568 HPA064739

Interaction Protein

ENSG00000168484

Interaction Count

Interaction Dataset

intact_biogrid