Protein detail

PVR

Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)

Protein symbol PVR	UniProt ID P15151	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)

Protein Class

CD markersPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins
CD markers
Predicted intracellular proteins

Transmembrane

344..367; Helical

Transmembrane Count

Ensembl

ENSG00000073008

Entrez Gene Symbol

PVR

Gene Synonym

CD155HVEDNecl-5NECL5PVSTage4

Gene Description

PVR cell adhesion molecule

Chromosome

Position

44643798-44666162

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificneutrophil

Function & Pathway

Protein Function

Predicted secreted proteins
CD markers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PVR	INSR	P06213	Y	398	phosphorylation	KEA	KEA:17570479
PVR	LCK	P06239	Y	398	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

64 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
secreted	secreted	OmniPath	No	No	Yes	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	Yes	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	Yes	Yes	No
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	No
receptor	receptor	talklr	No	Yes	Yes	Yes	No
receptor	receptor	scConnect	No	Yes	Yes	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	Yes	Yes	No
receptor	receptor	iTALK	No	Yes	Yes	Yes	No
receptor	receptor	Almen2009	No	Yes	Yes	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	Yes	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MARH9	Q86YJ5	PVR	P15151	Yes	No	Yes	SIGNOR	SIGNOR:19457934
PVR	P15151	CD226	Q15762	Yes	Yes	No	CellChatDBSparser_ProtMapperCellPhoneDBUniProt_LRdbICELLNETSIGNORProtMapperconnectomeDB2020HPRDHINTWojtowicz2020IntActLit-BM-17WangLRdb	Lit-BM-17:12913096 ProtMapper:33670993 ICELLNET:15034010 HINT:30591568 HINT:21982860 IntAct:21982860 HINT:12913096 connectomeDB2020:15607800 IntAct:30591568 SIGNOR:30591568 HINT:31253644 Lit-BM-17:21982860 HPRD:12913096
PVR	P15151	TIGIT	Q495A1	Yes	Yes	No	CellChatDBCellPhoneDBUniProt_LRdbICELLNETSIGNORconnectomeDB2020HINTWojtowicz2020IntActLit-BM-17LRdb	connectomeDB2020:19815499 IntAct:21982860 HINT:21982860 ICELLNET:27192565 HINT:28515320 HINT:22421438 IntAct:28515320 Lit-BM-17:21982860 SIGNOR:30591568

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
NTHL1 PVR RAE1 RTCA ZC3HAV1	O00442 P15151 P78406 P78549 Q7Z2W4	0:0:0:0:0	Havugimana2012	Havugimana2012:C_473
C4A NLRX1 PVR TMEM183BP	P0C0L4 P15151 Q1AE95 Q86UT6	0:0:0:0	hu.MAP2
PVRIG SEC11A SEC11C SPCS1 SPCS2 SPCS3	P61009 P67812 Q15005 Q6DKI7 Q9BY50 Q9Y6A9	0:0:0:0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	31414377

Sequence, Structure & Domains

Sequences

Length

417

Mass

45,303

Sequence

MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=Alpha; IsoId=P15151-1; Sequence=Displayed; Name=Beta; IsoId=P15151-2; Sequence=VSP_002617; Name=Gamma; IsoId=P15151-3; Sequence=VSP_002618, VSP_002619; Name=Delta; IsoId=P15151-4; Sequence=VSP_002620, VSP_002621

Alternative Sequence

331; E -> G (in isoform Gamma); 332..384; Missing (in isoform Gamma); 340..384; Missing (in isoform Beta); 385..392; TEHASASA -> EHHQSCRN (in isoform Delta); 393..417; Missing (in isoform Delta)

3D Structural Models

Turn

80..82; 89..91

Helix

115..117

Beta Strand

30..32; 35..40; 45..47; 50..52; 60..68; 71..73; 75..79; 83..88; 92..96; 108..110; 119..128; 131..142; 146..151; 161..173; 176..180; 186..193; 200..208; 212..214; 218..224; 228..230; 232..237; 245..249; 262..269; 275..285; 290..293; 296..299; 310..315; 320..329

3D Structure

Electron microscopy (7); X-ray crystallography (6)

Domain & Motif Annotations

Motif

396..401; ITIM motif

Domain (CC)

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Domain (FT)

24..139; Ig-like V-type; 145..237; Ig-like C2-type 1; 244..328; Ig-like C2-type 2

Region

368..372; DYNLT1 binding

Protein Families

Nectin family

Sequence Similarities

Belongs to the nectin family.

Clinical Relevance

Antibody

HPA012568 HPA064739

Interaction Protein

ENSG00000168484

Interaction Count

Interaction Dataset

intact_biogrid