Protein detail

MCP

Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)

Entry name MCP	UniProt ID P15529	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)

Protein Class

Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Cardiovascular diseases:Hematologic diseases
CD markers
Cancer-related genes:Candidate cancer biomarkers
Disease related genes

Transmembrane

344..366; Helical

Transmembrane Count

Ensembl

ENSG00000117335

Entrez Gene Symbol

CD46

Gene Synonym

MCPMGC26544MIC10TLXTRA2.10

Gene Description

CD46 molecule

Chromosome

Position

207752037-207795513

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Cardiovascular diseases:Hematologic diseases
CD markers
Cancer-related genes:Candidate cancer biomarkers
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

8 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CD46	YES1	P07947	Y	338	phosphorylation	HPRDKEA	KEA:11901164 HPRD:11901164
CD46	YES1	P07947	Y	324	phosphorylation	HPRDKEA	KEA:11901164 HPRD:11901164
CD46	YES1	P07947	Y	368	phosphorylation	MIMPHPRDHPRD_MIMPKEA	KEA:11901164 HPRD:11901164
CD46	YES1	P07947	Y	353	phosphorylation	HPRDKEA	KEA:11901164 HPRD:11901164
CD46	YES1	P07947	Y	339	phosphorylation	KEA	KEA:11901164
CD46	YES1	P07947	Y	354	phosphorylation	KEA	KEA:11901164
CD46	SRC	P12931	Y	354	phosphorylation	PhosphoSite
CD46	SRC	P12931	Y	384	phosphorylation	MIMPHPRD_MIMPPhosphoSite_MIMP

Ligand-Receptor Signaling

45 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	MCP	P15529	Yes	No	No	PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointHPRDSPIKE_LCPhosphoSite	PhosphoSite:11901164 HPRD:10657632 SPIKE_LC:16189514

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27894104

Sequence, Structure & Domains

Sequences

Length

392

Mass

43,747

Sequence

MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL

Alternative Products

Event=Alternative splicing; Named isoforms=16; Comment=Additional isoforms seem to exist. The complete sequences of the isoforms are not known. Isoforms are classified as alpha (isoform C and isoform D), beta (isoform E and isoform F), gamma (isoform A and isoform B) and delta (isoform N). Isoforms gamma are preferentially expressed in EBV-B cells and leukemic cells. Isoforms alpha (66 kDa) and isoforms beta (56 kDa) are found in all tissues except sperm. Isoform delta is expressed in spermatozoa. The exon 9 is specifically deleted in some placentae isoforms. All tissues differentially splice exon 13.; Name=A; Synonyms=no del, ABC1; IsoId=P15529-1; Sequence=Displayed; Name=B; Synonyms=del 13, ABC2; IsoId=P15529-2; Sequence=VSP_001204; Name=C; Synonyms=del 7, BC1; IsoId=P15529-11; Sequence=VSP_009174; Name=D; Synonyms=del 7-13, BC2; IsoId=P15529-3; Sequence=VSP_009174, VSP_001204; Name=E; Synonyms=del 7-8, C1; IsoId=P15529-12; Sequence=VSP_009175; Name=F; Synonyms=del 7-8-13, C2; IsoId=P15529-4; Sequence=VSP_009175, VSP_001204; Name=G; Synonyms=del 9; IsoId=P15529-13; Sequence=VSP_009177; Name=H; Synonyms=del 9-13; IsoId=P15529-5; Sequence=VSP_009177, VSP_001204; Name=I; Synonyms=del 7-9; IsoId=P15529-14; Sequence=VSP_009174, VSP_009177; Name=J; Synonyms=del 7-9-13; IsoId=P15529-6; Sequence=VSP_009174, VSP_009177, VSP_001204; Name=K; Synonyms=del 7-8-9; IsoId=P15529-15; Sequence=VSP_009176; Name=L; Synonyms=del 7-8-9-13; IsoId=P15529-7; Sequence=VSP_009176, VSP_001204; Name=M; Synonyms=del 7-12a-13; IsoId=P15529-8; Sequence=VSP_009174, VSP_001202, VSP_001203; Name=N; Synonyms=del 7-8-12-13; IsoId=P15529-9; Sequence=VSP_009175, VSP_009178; Name=2; IsoId=P15529-10; Sequence=VSP_001201; Name=3; IsoId=P15529-16; Sequence=VSP_019005, VSP_019006, VSP_001204

Alternative Sequence

33; D -> G (in isoform 3); 34..96; Missing (in isoform 3); 286..329; Missing (in isoform K and isoform L); 286..315; Missing (in isoform E, isoform F and isoform N); 286..300; Missing (in isoform C, isoform D, isoform I, isoform J and isoform M); 301..305; Missing (in isoform 2); 316..329; Missing (in isoform G, isoform H, isoform I and isoform J); 355..392; VVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL -> GKQMVELNMPLTRLNQPLQQSREAE (in isoform N); 355..367; Missing (in isoform M); 368..392; YLQRRKKKGTYLTDETHREVKFTSL -> GKQMVELNMPLTRLNQPLQQSREAE (in isoform M); 377..392; TYLTDETHREVKFTSL -> KADGGAEYATYQTKSTTPAEQRG (in isoform B, isoform D, isoform F, isoform H, isoform J, isoform L and isoform 3)

3D Structural Models

Helix

91..93; 212..214

Beta Strand

42..48; 59..64; 68..70; 72..74; 77..80; 84..86; 94..96; 108..112; 115..118; 122..127; 131..135; 137..146; 148..152; 156..159; 171..174; 183..191; 195..198; 201..204; 206..210; 215..218; 222..224; 236..240; 251..256; 260..264; 266..270; 276..278; 282..285

3D Structure

Electron microscopy (1); X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

291..315; Low complexity

Domain (CC)

Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles virus H protein. Sushi domains 2 and 3 are required for Herpesvirus 6 binding. Sushi domain 3 is required for Neisseria binding. Sushi domains 3 and 4 are required for interaction with Streptococcus pyogenes M protein and are the most important for interaction with C3b and C4b.

Domain (FT)

35..96; Sushi 1; 97..159; Sushi 2; 160..225; Sushi 3; 226..285; Sushi 4

Region

291..328; Disordered

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantHemolytic uremic syndrome

Related Diseases

Multiple myeloma

Biomarker

Phase 1

Drug Targets

Clinical trial target

Antibody

CAB010401 HPA016903