Protein detail

MCP

Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)

Entry name MCP	UniProt ID P15529	EVMP confidence score 0.53
Supporting publications (n) 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46)

Protein Class (7)

Cancer-related genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (5)

Predicted intracellular proteins
Human disease related genes:Cardiovascular diseases:Hematologic diseases
CD markers
Cancer-related genes:Candidate cancer biomarkers
Disease related genes

Transmembrane

344..366; Helical

Transmembrane Count

Ensembl

ENSG00000117335

Entrez Gene Symbol

CD46

Gene Synonym (5)

MCPMGC26544MIC10TLXTRA2.10

Gene Description

CD46 molecule

Chromosome

Position

207752037-207795513

Supporting publications (n)

EVMP confidence score

0.53

Function & Pathway

Protein Function (5)

Predicted intracellular proteins
Human disease related genes:Cardiovascular diseases:Hematologic diseases
CD markers
Cancer-related genes:Candidate cancer biomarkers
Disease related genes

Cellular Component (6)

Molecular Function (4)

Biological Process (3)

KEGG (4)

Reactome (2)

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence55

Enzyme-Mediated Modification (8)

8 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CD46	YES1	P07947	Y	338	phosphorylation	HPRDKEA	KEA:11901164 HPRD:11901164
CD46	YES1	P07947	Y	324	phosphorylation	HPRDKEA	KEA:11901164 HPRD:11901164
CD46	YES1	P07947	Y	368	phosphorylation	MIMPHPRDHPRD_MIMPKEA	KEA:11901164 HPRD:11901164
CD46	YES1	P07947	Y	353	phosphorylation	HPRDKEA	KEA:11901164 HPRD:11901164
CD46	YES1	P07947	Y	339	phosphorylation	KEA	KEA:11901164
CD46	YES1	P07947	Y	354	phosphorylation	KEA	KEA:11901164
CD46	SRC	P12931	Y	354	phosphorylation	PhosphoSite
CD46	SRC	P12931	Y	384	phosphorylation	MIMPHPRD_MIMPPhosphoSite_MIMP

Ligand-Receptor Signaling (45)

45 records.

Category	Parent	Database	Plasma Membrane (Transmembrane)
transmembrane	transmembrane	UniProt_keyword	Yes
transmembrane_predicted	transmembrane	OmniPath	Yes
transmembrane	transmembrane	CellPhoneDB	Yes
transmembrane	transmembrane	TopDB	Yes
transmembrane	transmembrane	LOCATE	Yes
transmembrane	transmembrane	Ramilowski_location	Yes
transmembrane	transmembrane	OmniPath	Yes
plasma_membrane	plasma_membrane	Cellinker	Yes
plasma_membrane	plasma_membrane	OmniPath	Yes
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	Yes

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	MCP	P15529	Yes			PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointHPRDSPIKE_LCPhosphoSite	PhosphoSite:11901164 HPRD:10657632 SPIKE_LC:16189514

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	27894104

Sequence, Structure & Domains

Sequences

Length

392

Mass

43,747

Sequence

MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL

Alternative Products

Event=Alternative splicing; Named isoforms=16; Comment=Additional isoforms seem to exist. The complete sequences of the isoforms are not known. Isoforms are classified as alpha (isoform C and isoform D), beta (isoform E and isoform F), gamma (isoform A and isoform B) and delta (isoform N). Isoforms gamma are preferentially expressed in EBV-B cells and leukemic cells. Isoforms alpha (66 kDa) and isoforms beta (56 kDa) are found in all tissues except sperm. Isoform delta is expressed in spermatozoa. The exon 9 is specifically deleted in some placentae isoforms. All tissues differentially splice exon 13.; Name=A; Synonyms=no del, ABC1; IsoId=P15529-1; Sequence=Displayed; Name=B; Synonyms=del 13, ABC2; IsoId=P15529-2; Sequence=VSP_001204; Name=C; Synonyms=del 7, BC1; IsoId=P15529-11; Sequence=VSP_009174; Name=D; Synonyms=del 7-13, BC2; IsoId=P15529-3; Sequence=VSP_009174, VSP_001204; Name=E; Synonyms=del 7-8, C1; IsoId=P15529-12; Sequence=VSP_009175; Name=F; Synonyms=del 7-8-13, C2; IsoId=P15529-4; Sequence=VSP_009175, VSP_001204; Name=G; Synonyms=del 9; IsoId=P15529-13; Sequence=VSP_009177; Name=H; Synonyms=del 9-13; IsoId=P15529-5; Sequence=VSP_009177, VSP_001204; Name=I; Synonyms=del 7-9; IsoId=P15529-14; Sequence=VSP_009174, VSP_009177; Name=J; Synonyms=del 7-9-13; IsoId=P15529-6; Sequence=VSP_009174, VSP_009177, VSP_001204; Name=K; Synonyms=del 7-8-9; IsoId=P15529-15; Sequence=VSP_009176; Name=L; Synonyms=del 7-8-9-13; IsoId=P15529-7; Sequence=VSP_009176, VSP_001204; Name=M; Synonyms=del 7-12a-13; IsoId=P15529-8; Sequence=VSP_009174, VSP_001202, VSP_001203; Name=N; Synonyms=del 7-8-12-13; IsoId=P15529-9; Sequence=VSP_009175, VSP_009178; Name=2; IsoId=P15529-10; Sequence=VSP_001201; Name=3; IsoId=P15529-16; Sequence=VSP_019005, VSP_019006, VSP_001204

Alternative Sequence

33; D -> G (in isoform 3); 34..96; Missing (in isoform 3); 286..329; Missing (in isoform K and isoform L); 286..315; Missing (in isoform E, isoform F and isoform N); 286..300; Missing (in isoform C, isoform D, isoform I, isoform J and isoform M); 301..305; Missing (in isoform 2); 316..329; Missing (in isoform G, isoform H, isoform I and isoform J); 355..392; VVGVAVICVVPYRYLQRRKKKGTYLTDETHREVKFTSL -> GKQMVELNMPLTRLNQPLQQSREAE (in isoform N); 355..367; Missing (in isoform M); 368..392; YLQRRKKKGTYLTDETHREVKFTSL -> GKQMVELNMPLTRLNQPLQQSREAE (in isoform M); 377..392; TYLTDETHREVKFTSL -> KADGGAEYATYQTKSTTPAEQRG (in isoform B, isoform D, isoform F, isoform H, isoform J, isoform L and isoform 3)

3D Structural Models

Helix

91..93; 212..214

Beta Strand

42..48; 59..64; 68..70; 72..74; 77..80; 84..86; 94..96; 108..112; 115..118; 122..127; 131..135; 137..146; 148..152; 156..159; 171..174; 183..191; 195..198; 201..204; 206..210; 215..218; 222..224; 236..240; 251..256; 260..264; 266..270; 276..278; 282..285

3D Structure

Electron microscopy (1); X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

291..315; Low complexity

Domain (CC)

Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles virus H protein. Sushi domains 2 and 3 are required for Herpesvirus 6 binding. Sushi domain 3 is required for Neisseria binding. Sushi domains 3 and 4 are required for interaction with Streptococcus pyogenes M protein and are the most important for interaction with C3b and C4b.

Domain (FT)

35..96; Sushi 1; 97..159; Sushi 2; 160..225; Sushi 3; 226..285; Sushi 4

Region

291..328; Disordered

Clinical Relevance

Disease Involvement (3)

Cancer-related genesDisease variantHemolytic uremic syndrome

Related Diseases (2)

Hemolytic uremic syndrome Multiple myeloma

Biomarker

Phase 1

Drug Targets

Clinical trial target

Antibody (2)

CAB010401 HPA016903

Supporting Publications1

PMID	Title	Related sentences
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No related sentences available