Protein detail
CD1D
Antigen-presenting glycoprotein CD1d (R3G1) (CD antigen CD1d)
Entry name CD1D | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 5 | Transmembrane count 1 | Protein classification Cancer-related genesCD markersPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Antigen-presenting glycoprotein CD1d (R3G1) (CD antigen CD1d)
Protein Class (3)
Cancer-related genesCD markersPredicted membrane proteins
Protein Function (2)
- Cancer-related genes:Mutated cancer genes
- CD markers
Transmembrane
302..322; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
CD1d molecule
Chromosome
1
Position
158178030-158186427
Supporting publications (n)
5
EVMP confidence score
0.25
Fluorescence & Localization3
Tissue SpecificintestineCell SpecificAstrocytes
Function & Pathway7
Protein Function (2)
- Cancer-related genes:Mutated cancer genes
- CD markers
Cellular Component (11)
- GO:0005615 extracellular space
- GO:0005737 cytoplasm
- GO:0005764 lysosome
- GO:0005765 lysosomal membrane
- GO:0005783 endoplasmic reticulum
- GO:0005789 endoplasmic reticulum membrane
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0010008 endosome membrane
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Molecular Function (7)
Biological Process (3)
Reactome (2)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationImmune mediation
Relations & Evidence42
Ligand-Receptor Signaling (41)
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains9
Sequences
Length
335
Mass
37,717
Sequence
MGCLLFLLLWALLQAWGSAEVPQRLFPLRCLQISSFANSSWTRTDGLAWLGELQTHSWSNDSDTVRSLKPWSQGTFSDQQWETLQHIFRVYRSSFTRDVKEFAKMLRLSYPLELQVSAGCEVHPGNASNNFFHVAFQGKDILSFQGTSWEPTQEAPLWVNLAIQVLNQDKWTRETVQWLLNGTCPQFVSGLLESGKSELKKQVKPKAWLSRGPSPGPGRLLLVCHVSGFYPKPVWVKWMRGEQEQQGTQPGDILPNADETWYLRATLDVVAGEAAGLSCRVKHSSLEGQDIVLYWGGSYTSMGLIALAVLACLLFLLIVGFTSRFKRQTSYQGVL
3D Structural Models
Turn
70..75; 124..126; 257..259; 271..273
Helix
23..25; 78..105; 158..166; 170..181; 183..194; 196..199; 284..286
Beta Strand
28..38; 41..50; 53..58; 60..64; 66..69; 112..122; 128..136; 139..145; 148..151; 206..211; 215..218; 219..232; 235..240; 241..243; 248..250; 261..270; 278..282; 291..294
3D Structure
X-ray crystallography (21)
Domain & Motif Annotations
Motif
331..334; Internalization signal
Domain (FT)
185..292; Ig-like
Clinical Relevance3
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No abstract available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 36635400 | Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study. | No abstract available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No abstract available |