Protein detail

TSHR

Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)

Entry name TSHR	UniProt ID P16473	EVMP confidence score 0.25
Supporting publications (n) 3	Transmembrane count 7	Protein classification Cancer-related genesDisease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)

Protein Class (7)

Cancer-related genesDisease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
Cancer-related genes
FDA approved drug targets:Biotech drugs

Transmembrane

415..440; Helical; Name=1; 451..473; Helical; Name=2; 493..517; Helical; Name=3; 538..558; Helical; Name=4; 577..602; Helical; Name=5; 626..649; Helical; Name=6; 658..681; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000165409

Entrez Gene Symbol

TSHR

Gene Synonym

LGR3

Gene Description

Thyroid stimulating hormone receptor

Chromosome

Position

80954989-81146306

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization1

Cell SpecificNeutrophils

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
Cancer-related genes
FDA approved drug targets:Biotech drugs

Cellular Component (4)

Molecular Function (5)

Biological Process (3)

KEGG (6)

Reactome (5)

Mediation Categories (3)

Clinical-translation mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence76

Ligand-Receptor Signaling (65)

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
matrix_adhesion	matrix_adhesion	OmniPath	No	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No

Page 4 of 7Previous Next

Regulatory Interaction Network (9)

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GLHA	P01215	TSHR	P16473	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTHPMRCellChatDBtalklrRamilowski2015_Baccin2019WangRamilowski2015Reactome_LRdbGuide2Pharma_talklrBaccin2019STRING_talklrCellCallGuide2PharmaFantom5_LRdbCellTalkDBNetPathLRdb	HINT:35940204 HINT:35940205 HPMR:15571461 SIGNOR:12045258 NetPath:20181794
GPHA2	Q96T91	TSHR	P16473	Yes	Yes	No	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbHPMR_talklr	CellTalkDB:12045258 LRdb:12045258 Cellinker:12045258 connectomeDB2020:12045258 SIGNOR:12045258 Baccin2019:12045258
TSHR	P16473	GNAS3	O95467	Yes	Yes	No	KEGG-MEDICUSNetPathSIGNORHPRDHINT	HINT:35940204 HINT:35940205 NetPath:17891229 HPRD:9525885 HINT:9525885 SIGNOR:25878058
TSHR	P16473	ALEX	P84996	Yes	Yes	No	KEGG-MEDICUSNetPathSIGNORHPRDHINT	HINT:35940204 HINT:35940205 NetPath:17891229 HPRD:9525885 HINT:9525885 SIGNOR:25878058
TSHR	P16473	GNAS2	P63092	Yes	Yes	No	KEGG-MEDICUSNetPathSIGNORHPRDHINT	HINT:35940204 HINT:35940205 NetPath:17891229 HPRD:9525885 HINT:9525885 SIGNOR:25878058
TSHR	P16473	GNAS1	Q5JWF2	Yes	Yes	No	KEGG-MEDICUSNetPathSIGNORHPRDHINT	HINT:35940204 HINT:35940205 NetPath:17891229 HPRD:9525885 HINT:9525885 SIGNOR:25878058
TSHR	P16473	GNAQ	P50148	Yes	Yes	No	KEGG-MEDICUSHPRDNetPathSIGNOR	SIGNOR:32698392 NetPath:17891229 HPRD:8188646
TSHB	P01222	TSHR	P16473	Yes	Yes	No	iTALKKEGG-MEDICUSGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBReactome_LRdbGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020LRdb	HINT:35940204 HINT:35940205 HPMR:15571461 SIGNOR:12045258 connectomeDB2020:15571461 Cellinker:15571461LRdb:26CellTalkDB:15571461 connectomeDB2020:2558651 LRdb:15571461 NetPath:20181794 Cellinker:2558651 HPRD:2558651
	COMPLEX:P01215_P01222	TSHR	P16473	Yes	Yes	No	CellPhoneDBCellChatDBSIGNOR	CellChatDB:12045259 SIGNOR:25905363

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ITPA TSHR	P16473 Q9BY32	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains13

Sequences

Length

764

Mass

86,844

Sequence

MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=Long; IsoId=P16473-1; Sequence=Displayed; Name=Short; IsoId=P16473-2; Sequence=VSP_001981, VSP_001982; Name=3; IsoId=P16473-3; Sequence=VSP_044643, VSP_044644

Alternative Sequence

232..274; DVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTR -> VENVAVSGKGFCKSLFSWLYRLPLGRKSLSFETQKAPRSSMPS (in isoform 3); 232..253; DVSQTSVTALPSKGLEHLKELI -> LPLGRKSLSFETQKAPRSSMPS (in isoform Short); 254..764; Missing (in isoform Short); 275..764; Missing (in isoform 3)

3D Structural Models

Turn

35..37; 69..74; 94..96; 169..174; 194..199; 218..223; 477..480; 525..527; 666..668; 679..681

Helix

246..248; 266..269; 281..286; 295..304; 377..390; 417..441; 448..476; 481..490; 492..524; 529..531; 535..558; 577..608; 620..648; 656..665; 669..678; 683..696

Beta Strand

26..28; 30..33; 38..41; 56..61; 65..67; 80..84; 97..99; 105..111; 121..123; 130..136; 152..160; 175..183; 190..192; 201..206; 229..232; 243..245; 250..253; 274..276; 278..280; 397..400; 404..406; 442..444; 611..613

3D Structure

Electron microscopy (7); X-ray crystallography (2)

Domain & Motif Annotations

Repeat

100..124; LRR 1; 125..150; LRR 2; 152..174; LRR 3; 176..199; LRR 4; 200..223; LRR 5; 227..248; LRR 6; 250..271; LRR 7

Motif

762..764; PDZ-binding

Protein Families (2)

G-protein coupled receptor 1 family
FSH/LSH/TSH subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.

Clinical Relevance9

Disease Involvement (4)

Cancer-related genesCongenital hypothyroidismDisease variantFDA approved drug targets

Related Diseases (2)

Hypo-thyroidism Thyroid cancer

Biomarker

Approved

Drug Targets

FDA approved drug targets

Drugs (94)

LY-255283 GW405833 TESTOSTERONE PROPIONATE CHEMBL:CHEMBL606166 CHEMBL:CHEMBL312032 LASALOCID A SODIUM CLOTRIMAZOLE HEXACHLOROPHENE CHEMBL:CHEMBL278751 GM-CSF THYROTROPIN ALFA CHEMBL:CHEMBL581194 AM-630 LORATADINE ENDRIN NICLOSAMIDE 1,3-DITOLYLGUANIDINE CHEMBL:CHEMBL429095 DINOPROSTONE SULFISOXAZOLE PSORA-4 BERGAMOTTIN CHEMBL:CHEMBL505670 JWH015 CAMBINOL ALPHA-NAPHTHOFLAVONE 4-CHLORO-BENZOIC ACID ISOPROTERENOL ASPIRIN THYROTROPIN [125I]TSH (HUMAN)CHEMBL:CHEMBL1256740 CLIOXANIDE CHEMBL:CHEMBL607309 (S)-VERAPAMIL 1R,9S-HYDRASTINE 3,6-DIMETHOXYFLAVONE ANTISERUM COUMARIN-3-CARBOXYLIC ACID CHEMBL:CHEMBL597246 CHEMBL:CHEMBL457504 KINETIN CLOSANTEL THERAPEUTIC GLUCOCORTICOID CARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONE (R)-FLECAINIDE PNU-37883 COMPOUND 8B [PMID: 22408719]SIBUTRAMINE HYDROCHLORIDE 2,4-DIACETYLPHLOROGLUCINOL NMDA CHEMBL:CHEMBL530361 PIPERONYL BUTOXIDE SEROTONIN DEXPROPRANOLOL SR59230A PENTACHLOROPHENOL CHEMBL:CHEMBL601146 URAPIDIL CHEMBL:CHEMBL1456848 CILOSTAZOL ICI-199441 CHEMBL:CHEMBL249190 CHLORDANE KARANJIN DEGUELIN (S)-FLUOXETINE CHEMBL:CHEMBL584905 DICHLOROPHEN SB 222200 LOBARIC ACID CLORGILINE [3H]D-ASPARTIC ACID LOPERAMIDE INDOMETHACIN MORPHOLINYLAMIDE CHEMBL:CHEMBL577660 SCH-23390 CHEMBL:CHEMBL140220 (-)-U-50488 BISACODYL CHEMBL:CHEMBL578276 RAFOXANIDE METHYLTHIONINIUM CHLORIDE GRAMINE LONIDAMINE ATOMOXETINE HYDROCHLORIDE SB 218795 LEVALBUTEROL CP-339818 CHEMBL:CHEMBL1611308 TYRPHOSTIN AG 879 MAPROTILINE TYRPHOSTIN A9 DECANOIC ACID

Antibody

CAB000473

Interaction Protein (4)

ENSG00000067715ENSG00000163485ENSG00000165175ENSG00000180900

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
24700864	Human urinary exosomes as innate immune effectors.	No abstract available
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available