Protein detail
TSHR
Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)
Entry name TSHR | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 3 | Transmembrane count 7 | Protein classification Cancer-related genesDisease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)
Protein Class (7)
Cancer-related genesDisease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- Cancer-related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
415..440; Helical; Name=1; 451..473; Helical; Name=2; 493..517; Helical; Name=3; 538..558; Helical; Name=4; 577..602; Helical; Name=5; 626..649; Helical; Name=6; 658..681; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
LGR3
Gene Description
Thyroid stimulating hormone receptor
Chromosome
14
Position
80954989-81146306
Supporting publications (n)
3
EVMP confidence score
0.28
Fluorescence & Localization
Cell SpecificNeutrophils
Function & Pathway
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- Cancer-related genes
- FDA approved drug targets:Biotech drugs
Cellular Component (4)
Molecular Function (5)
Biological Process (3)
KEGG (6)
Reactome (5)
Mediation Categories (3)
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence76
Ligand-Receptor Signaling (65)
65 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | Cellinker | Yes | ||||
| basolateral_cell_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | OmniPath | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes | ||||
| cell_surface | cell_surface | connectomeDB2020 | Yes |
Regulatory Interaction Network (9)
9 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GLHA | P01215 | TSHR | P16473 | Yes | Yes | iTALKGuide2Pharma_LRdbSIGNORHINTHPMRCellChatDBtalklrRamilowski2015_Baccin2019WangRamilowski2015Reactome_LRdbGuide2Pharma_talklrBaccin2019STRING_talklrCellCallGuide2PharmaFantom5_LRdbCellTalkDBNetPathLRdb | HINT:35940204HINT:35940205HPMR:15571461SIGNOR:12045258NetPath:20181794 | |
| GPHA2 | Q96T91 | TSHR | P16473 | Yes | Yes | Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020Baccin2019Ramilowski2015_Baccin2019CellinkerWangLRdbHPMR_talklr | CellTalkDB:12045258LRdb:12045258Cellinker:12045258connectomeDB2020:12045258SIGNOR:12045258Baccin2019:12045258 | |
| TSHR | P16473 | GNAS3 | O95467 | Yes | Yes | KEGG-MEDICUSNetPathSIGNORHPRDHINT | HINT:35940204HINT:35940205NetPath:17891229HPRD:9525885HINT:9525885SIGNOR:25878058 | |
| TSHR | P16473 | ALEX | P84996 | Yes | Yes | KEGG-MEDICUSNetPathSIGNORHPRDHINT | HINT:35940204HINT:35940205NetPath:17891229HPRD:9525885HINT:9525885SIGNOR:25878058 | |
| TSHR | P16473 | GNAS2 | P63092 | Yes | Yes | KEGG-MEDICUSNetPathSIGNORHPRDHINT | HINT:35940204HINT:35940205NetPath:17891229HPRD:9525885HINT:9525885SIGNOR:25878058 | |
| TSHR | P16473 | GNAS1 | Q5JWF2 | Yes | Yes | KEGG-MEDICUSNetPathSIGNORHPRDHINT | HINT:35940204HINT:35940205NetPath:17891229HPRD:9525885HINT:9525885SIGNOR:25878058 | |
| TSHR | P16473 | GNAQ | P50148 | Yes | Yes | KEGG-MEDICUSHPRDNetPathSIGNOR | SIGNOR:32698392NetPath:17891229HPRD:8188646 | |
| TSHB | P01222 | TSHR | P16473 | Yes | Yes | iTALKKEGG-MEDICUSGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBReactome_LRdbGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020LRdb | HINT:35940204HINT:35940205HPMR:15571461SIGNOR:12045258connectomeDB2020:15571461Cellinker:15571461LRdb:26CellTalkDB:15571461connectomeDB2020:2558651LRdb:15571461NetPath:20181794Cellinker:2558651HPRD:2558651 | |
| COMPLEX:P01215_P01222 | TSHR | P16473 | Yes | Yes | CellPhoneDBCellChatDBSIGNOR | CellChatDB:12045259SIGNOR:25905363 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
764
Mass
86,844
Sequence
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=Long; IsoId=P16473-1; Sequence=Displayed; Name=Short; IsoId=P16473-2; Sequence=VSP_001981, VSP_001982; Name=3; IsoId=P16473-3; Sequence=VSP_044643, VSP_044644
Alternative Sequence
232..274; DVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTR -> VENVAVSGKGFCKSLFSWLYRLPLGRKSLSFETQKAPRSSMPS (in isoform 3); 232..253; DVSQTSVTALPSKGLEHLKELI -> LPLGRKSLSFETQKAPRSSMPS (in isoform Short); 254..764; Missing (in isoform Short); 275..764; Missing (in isoform 3)
3D Structural Models
Turn
35..37; 69..74; 94..96; 169..174; 194..199; 218..223; 477..480; 525..527; 666..668; 679..681
Helix
246..248; 266..269; 281..286; 295..304; 377..390; 417..441; 448..476; 481..490; 492..524; 529..531; 535..558; 577..608; 620..648; 656..665; 669..678; 683..696
Beta Strand
26..28; 30..33; 38..41; 56..61; 65..67; 80..84; 97..99; 105..111; 121..123; 130..136; 152..160; 175..183; 190..192; 201..206; 229..232; 243..245; 250..253; 274..276; 278..280; 397..400; 404..406; 442..444; 611..613
3D Structure
Electron microscopy (7); X-ray crystallography (2)
Domain & Motif Annotations
Repeat
100..124; LRR 1; 125..150; LRR 2; 152..174; LRR 3; 176..199; LRR 4; 200..223; LRR 5; 227..248; LRR 6; 250..271; LRR 7
Motif
762..764; PDZ-binding
Protein Families (2)
- G-protein coupled receptor 1 family
- FSH/LSH/TSH subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Clinical Relevance
Disease Involvement (4)
Cancer-related genesCongenital hypothyroidismDisease variantFDA approved drug targets
Related Diseases (3)
Biomarker
Approved
Drug Targets
FDA approved drug targets
Drugs (94)
LY-255283GW405833TESTOSTERONE PROPIONATECHEMBL:CHEMBL606166CHEMBL:CHEMBL312032LASALOCID A SODIUMCLOTRIMAZOLEHEXACHLOROPHENECHEMBL:CHEMBL278751GM-CSFTHYROTROPIN ALFACHEMBL:CHEMBL581194AM-630LORATADINEENDRINNICLOSAMIDE1,3-DITOLYLGUANIDINECHEMBL:CHEMBL429095DINOPROSTONESULFISOXAZOLEPSORA-4BERGAMOTTINCHEMBL:CHEMBL505670JWH015CAMBINOLALPHA-NAPHTHOFLAVONE4-CHLORO-BENZOIC ACIDISOPROTERENOLASPIRINTHYROTROPIN[125I]TSH (HUMAN)CHEMBL:CHEMBL1256740CLIOXANIDECHEMBL:CHEMBL607309(S)-VERAPAMIL1R,9S-HYDRASTINE3,6-DIMETHOXYFLAVONEANTISERUMCOUMARIN-3-CARBOXYLIC ACIDCHEMBL:CHEMBL597246CHEMBL:CHEMBL457504KINETINCLOSANTELTHERAPEUTIC GLUCOCORTICOIDCARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONE(R)-FLECAINIDEPNU-37883COMPOUND 8B [PMID: 22408719]SIBUTRAMINE HYDROCHLORIDE2,4-DIACETYLPHLOROGLUCINOLNMDACHEMBL:CHEMBL530361PIPERONYL BUTOXIDESEROTONINDEXPROPRANOLOLSR59230APENTACHLOROPHENOLCHEMBL:CHEMBL601146URAPIDILCHEMBL:CHEMBL1456848CILOSTAZOLICI-199441CHEMBL:CHEMBL249190CHLORDANEKARANJINDEGUELIN(S)-FLUOXETINECHEMBL:CHEMBL584905DICHLOROPHENSB 222200LOBARIC ACIDCLORGILINE[3H]D-ASPARTIC ACIDLOPERAMIDEINDOMETHACIN MORPHOLINYLAMIDECHEMBL:CHEMBL577660SCH-23390CHEMBL:CHEMBL140220(-)-U-50488BISACODYLCHEMBL:CHEMBL578276RAFOXANIDEMETHYLTHIONINIUM CHLORIDEGRAMINELONIDAMINEATOMOXETINE HYDROCHLORIDESB 218795LEVALBUTEROLCP-339818CHEMBL:CHEMBL1611308TYRPHOSTIN AG 879MAPROTILINETYRPHOSTIN A9DECANOIC ACID
Antibody
Interaction Protein (4)
ENSG00000067715ENSG00000163485ENSG00000165175ENSG00000180900
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 24700864 | Human urinary exosomes as innate immune effectors. | No related sentences available |
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No related sentences available |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |