Protein detail

IL7RA

Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)

Entry name IL7RA	UniProt ID P16871	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)

Protein Class (6)

Cancer-related genesCD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (5)

Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes

Transmembrane

240..264; Helical

Transmembrane Count

Ensembl

ENSG00000168685

Entrez Gene Symbol

IL7R

Gene Synonym (3)

CD127IL7RAlnc-IL7R

Gene Description

Interleukin 7 receptor

Chromosome

Position

35852695-35879603

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Tissue SpecificretinaCell SpecificRetinal bipolar cells

Function & Pathway7

Protein Function (5)

Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes

Cellular Component (6)

Molecular Function (4)

Biological Process (3)

KEGG (7)

Reactome (7)

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence86

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IL7R	JAK1	P23458	Y	449	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:27729062
IL7R	JAK3	P52333	Y	449	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27423467 ProtMapper:22551764

Ligand-Receptor Signaling (78)

78 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	Yes	Yes	No
receptor	receptor	GO_Intercell	No	Yes	Yes	Yes	No
receptor	receptor	HPMR	No	Yes	Yes	Yes	No
receptor	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	CellTalkDB	No	Yes	Yes	Yes	No
receptor	receptor	Surfaceome	No	Yes	Yes	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	Yes	Yes	No
receptor	receptor	Kirouac2010	No	Yes	Yes	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	Yes	Yes	No
receptor	receptor	LRdb	No	Yes	Yes	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL7RA	P16871	JAK1	P23458	Yes	Yes	No	NetPathSIGNORHPRDInnateDBWang	SIGNOR:18445337 HPRD:8647212 NetPath:20974963 NetPath:8647212 InnateDB:20167604 HPRD:15996891
IL7	P13232	IL7RA	P16871	Yes	Yes	No	iTALKKirouac2010SIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	InnateDB:8266077 DIP:1558969 SPIKE_LC:17145710 connectomeDB2020:10390077 Baccin2019:11858939 SPIKE:17145710 SIGNOR:8204885 Baccin2019:7522165 connectomeDB2020:7522165 HINT:19141282 HPRD:11858939 HINT:8266077 Lit-BM-17:1558969 SIGNOR:20089933 HPMR:7522165 DIP:8409434 IntAct:8266077 Baccin2019:10390077 HPMR:8128231 SPIKE:2317865 connectomeDB2020:11858939 Lit-BM-17:8409434 SignaLink3:8204885 LRdb:10390077 LRdb:11858939 SignaLink3:23331499 CellTalkDB:11858939 LRdb:7522165 HPRD:10390077 IntAct:19141282 NetPath:2317865 DIP:19141282 SPIKE_LC:2317865 Lit-BM-17:19141282
IL7RA	P16871	CRLF2	Q9HC73	Yes	Yes	No	NetPathHPRDHINTSignaLink3Wang	NetPath:10881176 HINT:28368013 SignaLink3:23331499 HPRD:11418668 SignaLink3:10974032

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IL7 IL7R	P13232 P16871	2:2	PDB	PDB:3di3PDB:3di2
	IL7R	P16871	2	PDB	PDB:7opbPDB:3up1PDB:6p67

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Small R sequencing (Illumi HiSeq 2000 (Solexa)R SequencingMass spectrometry	1	38207106

Sequence, Structure & Domains14

Sequences

Length

459

Mass

51,579

Sequence

MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIVKPEAPFDLSVVYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWTHVNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSYYFRTPEINNSSGEMDPILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=H20; IsoId=P16871-1; Sequence=Displayed; Name=3; Synonyms=H1; IsoId=P16871-2; Sequence=VSP_001714; Name=4; Synonyms=H6, Secreted; IsoId=P16871-3; Sequence=VSP_001713; Name=2; Synonyms=Secreted; IsoId=P16871-4; Sequence=VSP_012618, VSP_012619

Alternative Sequence

237..459; EMDPILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ -> LSLSYGPVSPIIRRLWNIFVRNQEK (in isoform 4); 237..252; EMDPILLTISILSFFS -> LSLSYGPVSPIIRQEL (in isoform 2); 253..459; Missing (in isoform 2); 293..459; NLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ -> VSVFGA (in isoform 3)

3D Structural Models

Turn

141..144

Helix

35..38; 123..125; 153..156; 192..194

Beta Strand

40..49; 52..61; 70..79; 81..84; 86..88; 91..97; 101..103; 105..111; 114..121; 133..140; 145..151; 158..160; 163..171; 179..191; 200..209; 211..213; 224..227

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Motif

217..221; WSXWS motif; 272..280; Box 1 motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

Domain (FT)

131..231; Fibronectin type-III

Protein Families (2)

Type I cytokine receptor family
Type 4 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Clinical Relevance6

Disease Involvement (3)

Cancer-related genesDisease variantSCID

Related Diseases (4)

Atopic eczema Diabetes mellitus Human immunodeficiency virus disease Type 2 diabetes mellitus

Biomarker

Phase 2; Phase 1

Drug Targets

Clinical trial target

Drugs (3)

GLYCOSYLATED RECOMBINANT HUMAN INTERLEUKIN-7 RUXOLITINIB OSE-127

Antibody (3)

CAB010215 HPA067550 CAB080603

Supporting Publications1

PMID	Title	Abstract
20031610	Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques.	No abstract available