Protein detail

IL7RA

Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)

Protein symbol IL7RA	UniProt ID P16871	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification Cancer-related genesCD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)

Protein Class

Cancer-related genesCD markersDisease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes

Transmembrane

240..264; Helical

Transmembrane Count

Ensembl

ENSG00000168685

Entrez Gene Symbol

IL7R

Gene Synonym

CD127IL7RAlnc-IL7R

Gene Description

Interleukin 7 receptor

Chromosome

Position

35852695-35879603

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificretinaCell SpecificRetinal bipolar cells

Function & Pathway

Protein Function

Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
IL7R	JAK1	P23458	Y	449	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:27729062
IL7R	JAK3	P52333	Y	449	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:27423467 ProtMapper:22551764

Ligand-Receptor Signaling

78 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	Baccin2019	No	Yes	Yes	Yes	No
receptor	receptor	SignaLink_function	No	Yes	Yes	Yes	No
cytokine	receptor	Almen2009	No	Yes	Yes	Yes	No
ig_like	receptor	Almen2009	No	Yes	Yes	Yes	No
type1_ig_like_cytokine	receptor	Almen2009	No	Yes	Yes	Yes	No
cytokine_receptor	receptor	CellPhoneDB	No	Yes	Yes	Yes	No
interleukin	receptor	Baccin2019	No	Yes	Yes	Yes	No
cytokine	receptor	Baccin2019	No	Yes	Yes	Yes	No
cytokine_type_1	receptor	HPMR	No	Yes	Yes	Yes	No
prolactin	receptor	HPMR	No	Yes	Yes	Yes	No

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Regulatory Interaction Network

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
IL7RA	P16871	JAK1	P23458	Yes	Yes	No	NetPathSIGNORHPRDInnateDBWang	SIGNOR:18445337 HPRD:8647212 NetPath:20974963 NetPath:8647212 InnateDB:20167604 HPRD:15996891
IL7	P13232	IL7RA	P16871	Yes	Yes	No	iTALKKirouac2010SIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	InnateDB:8266077 DIP:1558969 SPIKE_LC:17145710 connectomeDB2020:10390077 Baccin2019:11858939 SPIKE:17145710 SIGNOR:8204885 Baccin2019:7522165 connectomeDB2020:7522165 HINT:19141282 HPRD:11858939 HINT:8266077 Lit-BM-17:1558969 SIGNOR:20089933 HPMR:7522165 DIP:8409434 IntAct:8266077 Baccin2019:10390077 HPMR:8128231 SPIKE:2317865 connectomeDB2020:11858939 Lit-BM-17:8409434 SignaLink3:8204885 LRdb:10390077 LRdb:11858939 SignaLink3:23331499 CellTalkDB:11858939 LRdb:7522165 HPRD:10390077 IntAct:19141282 NetPath:2317865 DIP:19141282 SPIKE_LC:2317865 Lit-BM-17:19141282
IL7RA	P16871	CRLF2	Q9HC73	Yes	Yes	No	NetPathHPRDHINTSignaLink3Wang	NetPath:10881176 HINT:28368013 SignaLink3:23331499 HPRD:11418668 SignaLink3:10974032

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	IL7 IL7R	P13232 P16871	2:2	PDB	PDB:3di3PDB:3di2
	IL7R	P16871	2	PDB	PDB:7opbPDB:3up1PDB:6p67

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Small R sequencing (Illumi HiSeq 2000 (Solexa)R SequencingMass spectrometry	1	38207106

Sequence, Structure & Domains

Sequences

Length

459

Mass

51,579

Sequence

MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIVKPEAPFDLSVVYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWTHVNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSYYFRTPEINNSSGEMDPILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=H20; IsoId=P16871-1; Sequence=Displayed; Name=3; Synonyms=H1; IsoId=P16871-2; Sequence=VSP_001714; Name=4; Synonyms=H6, Secreted; IsoId=P16871-3; Sequence=VSP_001713; Name=2; Synonyms=Secreted; IsoId=P16871-4; Sequence=VSP_012618, VSP_012619

Alternative Sequence

237..459; EMDPILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ -> LSLSYGPVSPIIRRLWNIFVRNQEK (in isoform 4); 237..252; EMDPILLTISILSFFS -> LSLSYGPVSPIIRQEL (in isoform 2); 253..459; Missing (in isoform 2); 293..459; NLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ -> VSVFGA (in isoform 3)

3D Structural Models

Turn

141..144

Helix

35..38; 123..125; 153..156; 192..194

Beta Strand

40..49; 52..61; 70..79; 81..84; 86..88; 91..97; 101..103; 105..111; 114..121; 133..140; 145..151; 158..160; 163..171; 179..191; 200..209; 211..213; 224..227

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Motif

217..221; WSXWS motif; 272..280; Box 1 motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

Domain (FT)

131..231; Fibronectin type-III

Protein Families

Type I cytokine receptor family
Type 4 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Clinical Relevance

Disease Involvement

Cancer-related genesDisease variantSCID

Related Diseases

Atopic eczema Diabetes mellitus Human immunodeficiency virus disease Type 2 diabetes mellitus

Biomarker

Phase 2; Phase 1

Drug Targets

Clinical trial target

Drugs

GLYCOSYLATED RECOMBINANT HUMAN INTERLEUKIN-7 RUXOLITINIB OSE-127

Antibody

CAB010215 HPA067550 CAB080603