Protein detail

CR2

Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)

Entry name CR2	UniProt ID P20023	EVMP confidence score 0.38
Supporting publications (n) 8	Transmembrane count 1	Protein classification CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)

Protein Class (6)

CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (5)

Disease related genes
Predicted intracellular proteins
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases

Transmembrane

972..999; Helical

Transmembrane Count

Ensembl

ENSG00000117322

Entrez Gene Symbol

CR2

Gene Synonym (2)

C3DRCD21

Gene Description

Complement C3d receptor 2

Chromosome

Position

207453024-207489895

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificheart muscleCell SpecificAstrocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway7

Protein Function (5)

Disease related genes
Predicted intracellular proteins
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Human disease related genes:Immune system diseases:Allergies and autoimmune diseases

Cellular Component (5)

Molecular Function (8)

Biological Process (3)

KEGG (4)

Reactome (2)

Mediation Categories

Immune mediation

Relations & Evidence53

Ligand-Receptor Signaling (36)

36 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
innate_immune	receptor	ICELLNET	No	Yes	No	Yes	No
innate_immune_complement	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CR2	P20023	CD19	P15391	Yes	Yes	No	WangNetPathSIGNORHPRDSPIKE_LCSPIKE	SIGNOR:31732528 NetPath:14688345 SPIKE:14688345 NetPath:9597125 HPRD:1702139 SPIKE_LC:14688345

Protein Complex Composition (15)

15 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
CERF	CECR2 SMARCA2	P51531 Q9BXF3	0:0	SIGNOR	SIGNOR:SIGNOR-C340
CERF chromatin remodelling complexSMARCA5 variant	CECR2 SMARCA5	O60264 Q9BXF3	1:1	ComplexPortal	intact:EBI-59037112	15640247 14755292 28801535
CERF complex (CECR2-containing remodeling factor complex)	CECR2 SMARCA1	P28370 Q9BXF3	1:1	CORUMCompleatComplexPortal	CORUM:917intact:EBI-11784735Compleat:HC2498	15640247 14755292
Cholesterol_byDHCR24	DHCR24	Q15392	1	CellPhoneDBCellChatDB	CellPhoneDB:Cholesterol_byDHCR24
HT_DM_Cluster434	CECR2 SMARCA1 SMARCA5	O60264 P28370 Q9BXF3	1:1:1	Compleat	Compleat:HC1163	22036573
	ALG10 DHCR24 RER1 TMEM161A	O15258 Q15392 Q5BKT4 Q9NX61	0:0:0:0	hu.MAP
	C3 CR2	P01024 P20023	1:2	PDB	PDB:1ghqPDB:3oedPDB:1w2s
	NOL4L PYCR2 RALYL SKA1 SKA2 SKA3	Q86SE5 Q8IX90 Q8WVK7 Q96BD8 Q96C36 Q96MY1	0:0:0:0:0:0	hu.MAP2
	CRACR2A MCPH1	Q8NEM0 Q9BSW2	0:0	hu.MAP
	HAVCR2	Q8TDQ0	2	PDB	PDB:8tftPDB:5f71PDB:7m41PDB:6txz

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains10

Sequences

Length

1,033

Mass

112,916

Sequence

MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEAREVYSVDPYNPAS

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=A; IsoId=P20023-1; Sequence=Displayed; Name=B; IsoId=P20023-2; Sequence=VSP_001208, VSP_001209; Name=C; IsoId=P20023-3; Sequence=VSP_001210; Name=D; IsoId=P20023-4; Sequence=VSP_001210, VSP_001211

Alternative Sequence

499..524; Missing (in isoform B); 525..556; ITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTC -> NHLPTTPCYLQWGTHREFLRRFSIWNHGHLHM (in isoform B); 659; K -> KGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCE (in isoform C and isoform D); 716..723; Missing (in isoform D)

3D Structural Models

Beta Strand

32..34; 39..41; 46..51; 55..59; 62..66; 68..72; 74..77; 81..83; 99..103; 106..109; 113..118; 123..126; 128..132; 136..141; 145..147

3D Structure

Electron microscopy (1); X-ray crystallography (8)

Domain & Motif Annotations

Domain (FT)

21..84; Sushi 1; 89..148; Sushi 2; 152..212; Sushi 3; 213..273; Sushi 4; 274..344; Sushi 5; 349..408; Sushi 6; 409..468; Sushi 7; 469..524; Sushi 8; 525..595; Sushi 9; 600..659; Sushi 10; 660..716; Sushi 11; 717..781; Sushi 12; 786..845; Sushi 13; 849..909; Sushi 14; 910..970; Sushi 15

Protein Families

Receptors of complement activation (RCA) family

Sequence Similarities

Belongs to the receptors of complement activation (RCA) family.

Clinical Relevance3

Disease Involvement

Systemic lupus erythematosus

Drugs (5)

ADENOVIRUS VECTOR DECITABINE NULL PROGESTERONE AT-56

Antibody (3)

CAB002659 HPA052942 HPA060715

Supporting Publications8

PMID	Title	Abstract
27487081	Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No abstract available
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available
41068253	Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.	No abstract available