Protein detail
CR2
Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)
Entry name CR2 | UniProt ID | EVMP score 0.38 |
Frequency 8 | Transmembrane count 1 | Protein classification CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)
Protein Class
CD markersDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Transmembrane
972..999; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
C3DRCD21
Gene Description
Complement C3d receptor 2
Chromosome
1
Position
207453024-207489895
Frequency
8
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificAstrocytesSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
Cellular Component
Molecular Function
Biological Process
KEGG
Mediation Categories
Immune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| innate_immune | receptor | ICELLNET | No | Yes | No | Yes | No |
| innate_immune_complement | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
Page 1 of 4Next
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CR2 | P20023 | CD19 | P15391 | Yes | Yes | No | WangNetPathSIGNORHPRDSPIKE_LCSPIKE | SIGNOR:31732528NetPath:14688345SPIKE:14688345NetPath:9597125HPRD:1702139SPIKE_LC:14688345 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,033
Mass
112,916
Sequence
MGAAGLLGVFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCEKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNPPLAVCRSRSLAPVLCGIAAGLILLTFLIVITLYVISKHRARNYYTDTSQKEAFHLEAREVYSVDPYNPAS
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=A; IsoId=P20023-1; Sequence=Displayed; Name=B; IsoId=P20023-2; Sequence=VSP_001208, VSP_001209; Name=C; IsoId=P20023-3; Sequence=VSP_001210; Name=D; IsoId=P20023-4; Sequence=VSP_001210, VSP_001211
Alternative Sequence
499..524; Missing (in isoform B); 525..556; ITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTC -> NHLPTTPCYLQWGTHREFLRRFSIWNHGHLHM (in isoform B); 659; K -> KGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCE (in isoform C and isoform D); 716..723; Missing (in isoform D)
3D Structural Models
Beta Strand
32..34; 39..41; 46..51; 55..59; 62..66; 68..72; 74..77; 81..83; 99..103; 106..109; 113..118; 123..126; 128..132; 136..141; 145..147
3D Structure
Electron microscopy (1); X-ray crystallography (8)
Domain & Motif Annotations
Domain (FT)
21..84; Sushi 1; 89..148; Sushi 2; 152..212; Sushi 3; 213..273; Sushi 4; 274..344; Sushi 5; 349..408; Sushi 6; 409..468; Sushi 7; 469..524; Sushi 8; 525..595; Sushi 9; 600..659; Sushi 10; 660..716; Sushi 11; 717..781; Sushi 12; 786..845; Sushi 13; 849..909; Sushi 14; 910..970; Sushi 15
Protein Families
Receptors of complement activation (RCA) family
Sequence Similarities
Belongs to the receptors of complement activation (RCA) family.
Clinical Relevance
Disease Involvement
Systemic lupus erythematosus