Protein detail
ATP4A
Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
Entry name ATP4A | UniProt ID | EVMP confidence score 0.35 |
Supporting publications (n) 0 | Transmembrane count 10 | Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
Protein Class (6)
EnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function (4)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
99..119; Helical; 143..163; Helical; 300..319; Helical; 332..349; Helical; 784..803; Helical; 814..834; Helical; 855..877; Helical; 930..949; Helical; 964..982; Helical; 998..1018; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
ATP6A
Gene Description
ATPase H+/K+ transporting subunit alpha
Chromosome
19
Position
35550031-35563658
Supporting publications (n)
0
EVMP confidence score
0.35
Fluorescence & Localization
Cell SpecificMicroglia
Function & Pathway
Protein Function (4)
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component (4)
Molecular Function (6)
Biological Process (3)
- GO:0002477 antigen processing and presentation of exogenous peptide antigen via MHC class Ib
- GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib
KEGG (4)
Reactome (3)
Mediation Categories (2)
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence22
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| extracellular | extracellular | OmniPath | |||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | OmniPath | |||||
| hk_atpase | transporter | HGNC | Yes | ||||
| transporter | transporter | HGNC | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword |
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Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,035
Mass
114,119
Sequence
MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY
Domain & Motif Annotations
Compositional Bias
26..40; Basic residues
Region
1..41; Disordered
Protein Families (2)
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IIC subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases (10)
Biomarker
Approved; Investigative; Phase 3; Preclinical
Drug Targets
FDA approved drug targets
Drugs (37)
PANTOPRAZOLE SODIUMLANSOPRAZOLENULLNN-DIMETHYL-D-ERYTHROSPHINGOSINEESOMEPRAZOLE SODIUMROSIGLITAZONEOMEPRAZOLE(S)-LIQUIRITIGENINRABEPRAZOLENIFEDIPINENARINGENINSPHINGOSINEESOMEPRAZOLE STRONTIUMOMEPRAZOLE MAGNESIUMMEFENAMIC ACIDNA+DIHYDROSPHINGOSINEFEXUPRAZANCHLOROFORMISOSAKURANETINTEGOPRAZANHALOTHANE2-APBILAPRAZOLETROGLITAZONEPREGNENOLONE SULPHATEESOMEPRAZOLE MAGNESIUMCIM0216MAPROTILINEPRIMIDONELA3+EPIPREGNANOLONE SULPHATEPIOGLITAZONE HYDROCHLORIDEDICLOFENAC SODIUMPENTAFLUORO-TRITYL CLOTRIMAZOLE ANALOGUE 29AGD3+VONOPRAZAN FUMARATE