Protein detail
ATP4A
Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
Protein symbol ATP4A | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 10 | Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
Protein Class
EnzymesFDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted membrane proteinsTransporters
Protein Function
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
99..119; Helical; 143..163; Helical; 300..319; Helical; 332..349; Helical; 784..803; Helical; 814..834; Helical; 855..877; Helical; 930..949; Helical; 964..982; Helical; 998..1018; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym
ATP6A
Gene Description
ATPase H+/K+ transporting subunit alpha
Chromosome
19
Position
35550031-35563658
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificMicroglia
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins
- Transporters:Primary Active Transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
- GO:0002477 antigen processing and presentation of exogenous peptide antigen via MHC class Ib
- GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,035
Mass
114,119
Sequence
MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY
3D Structural Models
Domain & Motif Annotations
Compositional Bias
26..40; Basic residues
Region
1..41; Disordered
Protein Families
- Cation transport ATPase (P-type) (TC 3.A.3) family
- Type IIC subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Approved; Investigative; Phase 3; Preclinical
Drug Targets
FDA approved drug targets
Drugs
PANTOPRAZOLE SODIUMLANSOPRAZOLENULLNN-DIMETHYL-D-ERYTHROSPHINGOSINEESOMEPRAZOLE SODIUMROSIGLITAZONEOMEPRAZOLE(S)-LIQUIRITIGENINRABEPRAZOLENIFEDIPINENARINGENINSPHINGOSINEESOMEPRAZOLE STRONTIUMOMEPRAZOLE MAGNESIUMMEFENAMIC ACIDNA+DIHYDROSPHINGOSINEFEXUPRAZANCHLOROFORMISOSAKURANETINTEGOPRAZANHALOTHANE2-APBILAPRAZOLETROGLITAZONEPREGNENOLONE SULPHATEESOMEPRAZOLE MAGNESIUMCIM0216MAPROTILINEPRIMIDONELA3+EPIPREGNANOLONE SULPHATEPIOGLITAZONE HYDROCHLORIDEDICLOFENAC SODIUMPENTAFLUORO-TRITYL CLOTRIMAZOLE ANALOGUE 29AGD3+VONOPRAZAN FUMARATE