Protein detail

5NTD

5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73)

Entry name
5NTD
UniProt ID
P21589
EVMP confidence score
0.38
Supporting publications (n)
1
Transmembrane count
Protein classification
CD markersDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73)
Protein Class (8)
CD markersDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (7)
  • Human disease related genes:Cardiovascular diseases:Vascular diseases
  • Predicted intracellular proteins
  • CD markers
  • Potential drug targets
  • Enzymes
  • ENZYME proteins:Hydrolases
  • Disease related genes
Ensembl
ENSG00000135318
Entrez Gene Symbol
NT5E
Gene Synonym (5)
CALJACD73eNeNTNT5
Gene Description
5'-nucleotidase ecto
Chromosome
6
Position
85449584-85495791
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificlymphoid tissueCell SpecificNeutrophilsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (7)
  • Human disease related genes:Cardiovascular diseases:Vascular diseases
  • Predicted intracellular proteins
  • CD markers
  • Potential drug targets
  • Enzymes
  • ENZYME proteins:Hydrolases
  • Disease related genes
Cellular Component (7)
Molecular Function (10)
Biological Process (3)
KEGG (5)
Reactome (10)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence39

Ligand-Receptor Signaling (35)

35 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
peripheralperipheralOmniPathNoNoNoYesYes
plasma_membraneplasma_membraneUniProt_locationNoNoNoYesYes
plasma_membraneplasma_membraneCellinkerNoNoNoYesYes
plasma_membraneplasma_membraneOmniPathNoNoNoYesYes
plasma_membrane_transmembraneplasma_membrane_transmembraneCSPANoNoNoYesYes
plasma_membrane_transmembraneplasma_membrane_transmembraneOmniPathNoNoNoYesYes
plasma_membrane_peripheralplasma_membrane_peripheralCSPANoNoNoYesYes
plasma_membrane_peripheralplasma_membrane_peripheralOmniPathNoNoNoYesYes
cell_surfacecell_surfaceSurfaceomeNoNoNoYesYes
cell_surfacecell_surfaceconnectomeDB2020NoNoNoYesYes
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Protein Complex Composition (3)

3 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
Adenosine_byNT5E_and_SLC29A3NT5ESLC29A3P21589Q9BZD21:1CellPhoneDBCellChatDBCellPhoneDB:Adenosine_byNT5E_and_SLC29A3
NT5EP215892PDBPDB:7bbjPDB:6hxwPDB:6ye1PDB:6xugPDB:6xuePDB:4h1sPDB:7jv9PDB:9hjgPDB:6ye2PDB:8znzPDB:9i1hPDB:7jv8PDB:6vca
NT5EUSP22USP3P21589Q9UPT9Q9Y6I40:0:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry23801459527487081
Sequence, Structure & Domains11

Sequences

Length
574
Mass
63,368
Sequence
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P21589-1; Sequence=Displayed; Name=2; IsoId=P21589-2; Sequence=VSP_043076
Alternative Sequence
404..453; Missing (in isoform 2)

3D Structural Models

Turn
121..124; 155..157; 377..379; 400..404; 439..443
Helix
54..56; 61..74; 91..96; 99..108; 117..120; 125..128; 131..134; 148..154; 181..184; 196..209; 223..232; 318..335; 350..353; 359..371; 372..374; 391..393; 408..414; 428..438; 499..502; 505..507; 509..514; 524..535
Beta Strand
27..34; 48..50; 76..82; 87..90; 111..114; 142..145; 158..166; 169..177; 191..193; 215..221; 233..235; 238..240; 250..252; 254..256; 263..268; 274..278; 285..294; 300..305; 337..344; 387..390; 405..407; 420..427; 450..459; 461..463; 469..475; 477..481; 484..486; 491..498; 516..523; 536..538; 544..548
3D Structure
Electron microscopy (1); X-ray crystallography (43)

Domain & Motif Annotations

Protein Families
5'-nucleotidase family
Sequence Similarities
Belongs to the 5'-nucleotidase family.
Clinical Relevance3
Disease Involvement
Disease variant
Drugs (19)
CETUXIMABCLOZAPINEVESNARINONEOLECLUMABIMMUNOTHERAPEUTIC AGENTINOSITOLEPOETIN ALFADOXORUBICIN HYDROCHLORIDERECOMBINANT INTERFERONC5ACAPSAICINRESERPINEANTICONVULSANT AGENTLOVASTATINHALOPERIDOL DECANOATESULFASALAZINETINIDAZOLEDIAZOXIDEMUPADOLIMAB
Antibody
HPA017357
Supporting Publications1
PMIDTitleAbstract
37820772Human brain microvascular endothelial cells release different types of P-glycoprotein-containing extracellular vesicles upon exposure to doxorubicin.In addition, Pgp is localized in intracellular organelles involved in Pgp traffic and cycling and, by the release of extracellular vesicles (EVs), in intercellular Pgp transfer to cells with low Pgp expression.