Protein detail
5NTD
5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73)
Entry name 5NTD | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification CD markersDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73)
Protein Class (8)
CD markersDisease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (7)
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
- CD markers
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
CALJACD73eNeNTNT5
Gene Description
5'-nucleotidase ecto
Chromosome
6
Position
85449584-85495791
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificNeutrophilsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function (7)
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
- CD markers
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Disease related genes
Cellular Component (7)
Molecular Function (10)
- GO:0000166 nucleotide binding
- GO:0002953 5'-deoxynucleotidase activity
- GO:0005515 protein binding
- GO:0008253 5'-nucleotidase activity
- GO:0008270 zinc ion binding
- GO:0042802 identical protein binding
- GO:0050340 thymidylate 5'-phosphatase activity
- GO:0050483 IMP 5'-nucleotidase activity
- GO:0050484 GMP 5'-nucleotidase activity
- GO:0106411 XMP 5'-nucleosidase activity
Biological Process (3)
KEGG (5)
Reactome (10)
- R-hsa-5663205 infectious disease
- R-hsa-9658195 leishmania infection
- R-hsa-15869 metabolism of nucleotides
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-196807 nicotinate metabolism
- R-hsa-8956319 nucleotide catabolism
- R-hsa-9660826 purinergic signaling in leishmaniasis infection
- R-hsa-74259 purine catabolism
- R-hsa-73621 pyrimidine catabolism
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence39
Ligand-Receptor Signaling (35)
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane_predicted | Phobius | Yes | Yes | |||
| transmembrane_phobius | transmembrane_predicted | Almen2009 | Yes | Yes | |||
| transmembrane_sosui | transmembrane_predicted | Almen2009 | Yes | Yes | |||
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | Yes | Yes |
Page 4 of 4Previous
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Adenosine_byNT5E_and_SLC29A3 | NT5ESLC29A3 | P21589Q9BZD2 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:Adenosine_byNT5E_and_SLC29A3 | |
| NT5E | P21589 | 2 | PDB | PDB:7bbjPDB:6hxwPDB:6ye1PDB:6xugPDB:6xuePDB:4h1sPDB:7jv9PDB:9hjgPDB:6ye2PDB:8znzPDB:9i1hPDB:7jv8PDB:6vca | ||
| NT5EUSP22USP3 | P21589Q9UPT9Q9Y6I4 | 0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
574
Mass
63,368
Sequence
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P21589-1; Sequence=Displayed; Name=2; IsoId=P21589-2; Sequence=VSP_043076
Alternative Sequence
404..453; Missing (in isoform 2)
3D Structural Models
Turn
121..124; 155..157; 377..379; 400..404; 439..443
Helix
54..56; 61..74; 91..96; 99..108; 117..120; 125..128; 131..134; 148..154; 181..184; 196..209; 223..232; 318..335; 350..353; 359..371; 372..374; 391..393; 408..414; 428..438; 499..502; 505..507; 509..514; 524..535
Beta Strand
27..34; 48..50; 76..82; 87..90; 111..114; 142..145; 158..166; 169..177; 191..193; 215..221; 233..235; 238..240; 250..252; 254..256; 263..268; 274..278; 285..294; 300..305; 337..344; 387..390; 405..407; 420..427; 450..459; 461..463; 469..475; 477..481; 484..486; 491..498; 516..523; 536..538; 544..548
3D Structure
Electron microscopy (1); X-ray crystallography (43)
Domain & Motif Annotations
Protein Families
5'-nucleotidase family
Sequence Similarities
Belongs to the 5'-nucleotidase family.
Clinical Relevance
Disease Involvement
Disease variant
Drugs (19)
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37820772 | Human brain microvascular endothelial cells release different types of P-glycoprotein-containing extracellular vesicles upon exposure to doxorubicin. | In addition, Pgp is localized in intracellular organelles involved in Pgp traffic and cycling and, by the release of extracellular vesicles (EVs), in intercellular Pgp transfer to cells with low Pgp expression. |