Protein detail
DRD1
D(1A) dopamine receptor (Dopamine D1 receptor)
Protein symbol DRD1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
D(1A) dopamine receptor (Dopamine D1 receptor)
Protein Function
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
24..49; Helical; Name=1; 61..87; Helical; Name=2; 97..119; Helical; Name=3; 139..163; Helical; Name=4; 193..218; Helical; Name=5; 273..299; Helical; Name=6; 313..337; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAdipocytesSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
- GO:0005634 nucleus
- GO:0005789 endoplasmic reticulum membrane
- GO:0005886 plasma membrane
- GO:0005929 cilium
- GO:0042734 presynaptic membrane
- GO:0043197 dendritic spine
- GO:0045211 postsynaptic membrane
- GO:0060170 ciliary membrane
- GO:0097648 G protein-coupled receptor complex
- GO:0097730 non-motile cilium
- GO:0098978 glutamatergic synapse
- GO:0098982 GABA-ergic synapse
Molecular Function
- GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
- GO:0001965 G-protein alpha-subunit binding
- GO:0004930 G protein-coupled receptor activity
- GO:0004952 dopamine neurotransmitter receptor activity
- GO:0005515 protein binding
- GO:0032795 heterotrimeric G-protein binding
- GO:0035240 dopamine binding
- GO:1990763 arrestin family protein binding
Biological Process
KEGG
- hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04540 Gap junction
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05030 Cocaine addiction
- KEGG:hsa05031 Amphetamine addiction
- KEGG:hsa05032 Morphine addiction
- KEGG:hsa05034 Alcoholism
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DRD1 | PRKCB | P05771 | T | 360 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
| rhodopsin | receptor | Almen2009 | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
| 7tm_a | receptor | HPMR | No | Yes | No | Yes | No |
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Regulatory Interaction Network
10 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods | Mass spectrometry | 10 | 19056867265384823822545340545963327954142677501333709510384909584009834631320591 |
Sequence, Structure & Domains
Sequences
Length
446
Mass
49,293
Sequence
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
3D Structural Models
Turn
162..165
Helix
21..50; 52..56; 59..76; 78..87; 95..126; 128..134; 137..160; 192..202; 204..238; 265..298; 310..331; 335..345
3D Structure
Electron microscopy (23); X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Drugs
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