Protein detail
DRD1
D(1A) dopamine receptor (Dopamine D1 receptor)
Entry name DRD1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
D(1A) dopamine receptor (Dopamine D1 receptor)
Protein Function (2)
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
24..49; Helical; Name=1; 61..87; Helical; Name=2; 97..119; Helical; Name=3; 139..163; Helical; Name=4; 193..218; Helical; Name=5; 273..299; Helical; Name=6; 313..337; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificAdipocytesSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function (2)
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (12)
- GO:0005634 nucleus
- GO:0005789 endoplasmic reticulum membrane
- GO:0005886 plasma membrane
- GO:0005929 cilium
- GO:0042734 presynaptic membrane
- GO:0043197 dendritic spine
- GO:0045211 postsynaptic membrane
- GO:0060170 ciliary membrane
- GO:0097648 G protein-coupled receptor complex
- GO:0097730 non-motile cilium
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Molecular Function (8)
- GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
- GO:0001965 G-protein alpha-subunit binding
- GO:0004930 G protein-coupled receptor activity
- GO:0004952 dopamine neurotransmitter receptor activity
- GO:0005515 protein binding
- GO:0032795 heterotrimeric G-protein binding
- GO:0035240 dopamine binding
- GO:1990763 arrestin family protein binding
Biological Process (3)
KEGG (12)
- hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04540 Gap junction
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05030 Cocaine addiction
- KEGG:hsa05031 Amphetamine addiction
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Reactome (6)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence57
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DRD1 | PRKCB | P05771 | T | 360 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (44)
44 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| dopamine_7tm_a | receptor | HPMR | Yes | Yes | |||
| rhodopsin | receptor | Surfaceome | Yes | Yes | |||
| gpcr | receptor | Surfaceome | Yes | Yes | |||
| class_a_rhodopsin | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_aminergic | receptor | GPCRdb | Yes | Yes | |||
| class_a_rhodopsin_aminergic_dopamine | receptor | GPCRdb | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | HPMR | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes |
Regulatory Interaction Network (10)
10 records.
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods | Mass spectrometry | 10 | 19056867265384823822545340545963327954142677501333709510384909584009834631320591 |
Sequence, Structure & Domains
Sequences
Length
446
Mass
49,293
Sequence
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
3D Structural Models
Turn
162..165
Helix
21..50; 52..56; 59..76; 78..87; 95..126; 128..134; 137..160; 192..202; 204..238; 265..298; 310..331; 335..345
3D Structure
Electron microscopy (23); X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Drugs (193)
AMITRIPTYLINE HYDROCHLORIDEZM-306416NICARDIPINECHEMBL:CHEMBL429095NULLECOPIPAMPEXMETINIBACETOPHENAZINEDIHYDROERGOCRISTINEMETIZOLINETRAZODONECYPROHEPTADINE HYDROCHLORIDETYRAMINECYCLOBENZAPRINEL-741,626PROPAFENONELOXAPINE(S)-UH 301METHYLPHENIDATE HYDROCHLORIDEFLUPENTHIXOLMINAPRINEOLANZAPINEPROCHLORPERAZINEDAS-431 IVMOTESANIBCOMPOUND 8H [PMID: 22765894]SEMAXANIBMK-2461LEVODOPAILOPERIDONEDIHYDROERGOTAMINE MESYLATETHIETHYLPERAZINEEFAROXANPIRENPERONECLOZAPINEPERPHENAZINECARVEDILOLHALOPERIDOL DECANOATEDICYCLOMINE HYDROCHLORIDEFLUOXETINE HYDROCHLORIDECEDIRANIBLUCITANIBTINENGOTINIBFENOLDOPAM MESYLATEAMINEPTINSB 242084IMIPRAMINE HYDROCHLORIDECGP7930AMPEROZIDEKETANSERIN2-CHLOROADENOSINE-5-TRIPHOSPHATEGW7647K-00546ROTIGOTINESPIPERONEERGOLOID MESYLATES, USPOSI-930SITRAVATINIBN-DESMETHYLCLOZAPINEQUETIAPINE FUMARATETRIFLUPROMAZINEN-OLEOYLDOPAMINEBENZOXATHIANCHEMBL:CHEMBL1256191BP 897METHYLERGONOVINELINIFANIBBRIVANIBBROMOCRIPTINESPERMINEMINAPRINE HYDROCHLORIDEDORSOMORPHINGOSSYPOLCHEMBL:CHEMBL63329THIORIDAZINEBUPROPION HYDROCHLORIDEPERGOLIDECOMPOUND 8I [PMID: 22765894]PROMAZINEZUCLOPENTHIXOLIFENPRODILFLUPHENAZINE HYDROCHLORIDESB-415286PALIPERIDONETRIMIPRAMINEDROTRECOGIN ALFAMRS1523MEVIDALENSB 216763DOBUTAMINEELLIPTECINENIFEDIPINEGR 127935MELEVODOPA(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDEPROTRIPTYLINECOMPOUND 25 [PMID: 17935989]VEGFB(-)-N-PORPHYNORAPOMORPHINEYOHIMBINENOREPINEPHRINEPHENYLEPHRINENORTRIPTYLINEKETOTIFEN FUMARATECGS 21680CLOROTEPINEASPIRINCHEMBL:CHEMBL305195CARPHENAZINELISURIDEPEXIDARTINIBTAVAPADONNIPECOTIC ACIDAMOXAPINECAPSAZEPINEETILEVODOPAAPOMORPHINECATEQUENTINIBDOVITINIB(-)-STEPHOLIDINENINTEDANIB ESYLATEEPINASTINEA77636METERGOLINEDIHYDREXIDINEPHENAMILSKF-38393SKF-82958METHYSERGIDEFRUQUINTINIBSERTRALINE HYDROCHLORIDEPALMITOYL-CARNITINE2MESATPCLOMIPRAMINEILORASERTIBCALCIMYCINAMSACRINECOCAINECYCLIC ADENOSINE MONOPHOSPHATEWB 4101APOCIDEINECEP-11981VATALANIBCHEMBL:CHEMBL123349A68930PROPIOMAZINEMETHYLERGONOVINE MALEATERACEPINEPHRINEQUERCETINDOXEPIN HYDROCHLORIDEIDARUBICIN(R,S)-INDATRALINETRIFLUOPERAZINEPHENYLTOLOXAMINEPIMOZIDEDOPAMINEQUINACRINEEPINEPHRINEVINPOCETINEASENAPINEZICRONAPINEPICEATANNOLZIMELDINEBAY 11-7082MIANSERINMOLINDONEDEOXIEPINEPHRINEPRECLAMOLPAZOPANIBRG-1530MAPROTILINEVEGF RECEPTOR TYROSINE KINASE INHIBITOR IIIENOXIMONEMETITEPINEMIFEPRISTONEOPIPRAMOLCGS 15943PERGOLIDE MESYLATEBENZAMILPIRENZEPINEDEXTROAMPHETAMINE SULFATECHLORPROTHIXENEFORETINIBVEGFABUTACLAMOLNAN 190BAY-11-7085NICOTINE POLACRILEXIBCASERTIBSU-14813TIVOZANIBCHEMBL:CHEMBL601364PROMETHAZINE HYDROCHLORIDE
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37416779 | Extracellular vesicles carrying miR-6836 derived from resistant tumor cells transfer cisplatin resistance of epithelial ovarian cancer via DLG2-YAP1 signaling pathway. | Extracellular vesicles carrying miR-6836 derived from resistant tumor cells transfer cisplatin resistance of epithelial ovarian cancer via DLG2-YAP1 signaling pathway. |