Protein detail
TGM2
Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2)
Protein symbol TGM2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2)
Protein Class
Disease related genesEnzymesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
TGC
Gene Description
Transglutaminase 2
Chromosome
20
Position
38127385-38166578
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Predicted secreted proteins
- ENZYME proteins:Hydrolases
- Disease related genes
Cellular Component
- GO:0000785 chromatin
- GO:0000786 nucleosome
- GO:0005634 nucleus
- GO:0005739 mitochondrion
- GO:0005783 endoplasmic reticulum
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0031012 extracellular matrix
- GO:0048471 perinuclear region of cytoplasm
- GO:0062023 collagen-containing extracellular matrix
- GO:0070062 extracellular exosome
Molecular Function
- GO:0003810 protein-glutamine gamma-glutamyltransferase activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0005525 GTP binding
- GO:0008233 peptidase activity
- GO:0050568 protein-glutamine glutaminase activity
- GO:0120295 histone serotonyltransferase activity
- GO:0120297 histone dopaminyltransferase activity
- GO:0120298 peptide noradrenalinyltransferase activity
- GO:0120299 peptide histaminyltransferase activity
Biological Process
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TGM2 | PRKACA | P17612 | S | 215 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| TGM2 | PRKACA | P17612 | S | 216 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| TGM2 | PRKDC | P78527 | T | 162 | phosphorylation | PhosphoSite | |
| TGM2 | SRC | P12931 | Y | 369 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| ecm | ecm | UniProt_location | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | HPMR | No | No | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | TGM2 | P21980 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:22142843PhosphoSite:16870138 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| FN1-TGM2 complex | FN1TGM2 | P02751P21980 | 1:1 | CompleatCORUM | CORUM:2375Compleat:HC837 | 10684262 |
| TGM2-HD complex | HTTTGM2 | P21980P42858 | 1:1 | CompleatCORUM | CORUM:2243Compleat:HC1631 | 11442349 |
| TGM2-HD-CALM1 complex | CALM3HTTTGM2 | P0DP25P21980P42858 | 1:1:1 | Compleat | Compleat:HC2694 | 14985437 |
| TGM2-HD-CALM1 complex | CALM1HTTTGM2 | P21980P42858P62158 | 0:0:0 | CORUM | CORUM:2242 | 14985437 |
| TGM2 | P21980 | 6 | PDB | PDB:6a8pPDB:4pygPDB:6kzbPDB:3ly6PDB:9bc3PDB:1kv3 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryWestern blotting | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
687
Mass
77,329
Sequence
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P21980-1; Sequence=Displayed; Name=2; Synonyms=TGase-S; IsoId=P21980-2; Sequence=VSP_006411, VSP_006412; Name=3; Synonyms=TGH2; IsoId=P21980-3; Sequence=VSP_006413, VSP_006414
Alternative Sequence
287..349; VLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQP -> GELHAGMWVMSPGRGHEEHWSRNQDIPALVLPPATNTLNALCGLEPVTTLSGPLSNSHPSSGC (in isoform 3); 350..687; Missing (in isoform 3); 539..548; EKSVPLCILY -> GKALCSWSIC (in isoform 2); 549..687; Missing (in isoform 2)
3D Structural Models
Turn
52..54; 69..72; 227..229; 231..234; 251..253; 267..269; 387..389; 462..465; 468..471; 552..554; 570..573; 627..629
Helix
14..20; 24..26; 153..159; 189..198; 201..205; 207..213; 217..226; 245..247; 258..266; 277..291; 311..317; 376..380; 390..397; 440..443; 450..460; 548..551
Beta Strand
7..11; 28..30; 32..34; 39..48; 55..66; 73..79; 85..87; 89..95; 97..105; 113..123; 126..138; 164..170; 172..181; 235..239; 255..257; 272..275; 295..304; 306..309; 332..342; 347..350; 353..357; 365..369; 400..404; 412..414; 419..429; 433..438; 447..449; 473..478; 489..497; 499..501; 503..514; 520..534; 538..546; 560..569; 574..583; 590..595; 598..601; 603..610; 613..615; 619..625; 634..638; 647..654; 658..660; 662..669; 671..673; 676..682
3D Structure
Electron microscopy (1); X-ray crystallography (12)
Domain & Motif Annotations
Protein Families
- Transglutaminase superfamily
- Transglutaminase family
Sequence Similarities
Belongs to the transglutaminase superfamily. Transglutaminase family.
Clinical Relevance
Drugs
CISPLATINNULLSIROLIMUSDEHYDRATED ALCOHOLSODIUM BUTYRATEANTINEOPLASTIC AGENTAMPHOTERICIN B LIPOSOMALEFLORNITHINEGEMCITABINEIONOMYCINTAMOXIFENLEVAMISOLERETINYL ACETATEANTISERUMIL-12THROMBINDECITABINEATORVASTATIN CALCIUM TRIHYDRATEDOXORUBICIN HYDROCHLORIDEIL-6RECOMBINANT INTERLEUKIN-8PROGESTERONECORTICOTROPINCAMPTOTHECINPERFOSFAMIDEGENTAMICINACIVICINFINASTERIDEVITAMIN AHEPARINGARLICNERVE GROWTH FACTORHEPARAN SULFATETNF-ALPHARETINOIC ACID AGENTRECOMBINANT INTERLEUKIN-1RECOMBINANT VASCULAR ENDOTHELIAL GROWTH FACTORMIDAZOLAM HYDROCHLORIDEISOTRETINOINDEFEROXAMINE
Interaction Protein
ENSG00000115414ENSG00000173039
Interaction Count
2
Interaction Dataset
intact_biogrid